Xingtao Han*†, Jinjian Yang*, Zhankui Jia*, Pengtao Wei†, Han Zhang†, Wenwei Lv†, Jiantao Sun†, Qingxiang Huo†
Oncology Research, Vol.25, No.3, pp. 389-395, 2017, DOI:10.3727/096504016X14743324568129
Abstract The pre-mRNA splicing regulator serine–arginine protein kinase 1 (SRPK1), a member of the SR kinase
family, plays an essential role in cancer development and various pathophysiological processes. However, its
expression pattern and functions in renal cell carcinoma (RCC) remain unknown. Therefore, the aim of this
study was to assess the role of SRPK1 in RCC. Our data showed that SRPK1 was significantly upregulated in
human RCC tissues and cell lines. SRPK1 interference significantly inhibited the proliferation of RCC cells
and inhibited tumor growth in vivo. In addition, SRPK1 interference also suppressed migration and invasion
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