Ye Li*†‡, Haihong Luo§, Nan Xiao*, Jianmin Duan*, Zhiping Wang*, Shuanke Wang¶
Oncology Research, Vol.26, No.1, pp. 131-143, 2018, DOI:10.3727/096504017X14944585873631
Abstract Prostate cancer has become the most commonly diagnosed and the second leading cause of cancer-related
deaths in males. The long noncoding RNA second chromosome locus associated with prostate-1 (SChLAP1)
has been found to be overexpressed in a subset of prostate cancer. However, the significance and mechanism
of SChLAP1 in prostate cancer are not well known. In this study, we explored the role of SChLAP1 in prostate
cancer tissues, cell lines, and mouse models. The effect of SChLAP1 on miR-198 and MAPK1 was specifically
examined. We found that SChLAP1 expression was significantly increased in prostate cancer… More >
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