Priyadarshini Patel, Komal Parmar^*

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.12, pp. 2855-2903, 2025, DOI:10.32604/fdmp.2025.069428 - 31 December 2025

Abstract Tissue engineering has advanced remarkably in developing functional tissue substitutes for pharmaceutical and regenerative applications. Among emerging technologies, three-dimensional (3D) printing, or additive manufacturing, enables precise fabrication of biocompatible materials, living cells, and scaffolds into complex, viable constructs. Within regenerative medicine, 3D bioprinting addresses the growing demand for transplantable tissues and organs by assembling biological materials that replicate native architectures. This paper reviews biomaterials used in 3D bioprinting, emphasizing how their rheological behavior, particularly viscoelasticity and thixotropy, governs printability, structural fidelity, and cellular viability. The advantages and limitations of natural, synthetic, and composite bioinks are More > Graphic Abstract

Rafl M. Kamil¹, Shaik Nyamathulla^1,*, Syed Mahmood^1,2,3,4,*

Journal of Polymer Materials, Vol.42, No.4, pp. 959-992, 2025, DOI:10.32604/jpm.2025.072005 - 26 December 2025

Abstract With the global diabetes epidemic, diabetic foot ulcers (DFUs) have become a major health burden, affecting approximately 18 million people worldwide each year, and account for about 80% of diabetes-related amputations. Five-year mortality among DFU patients approaches 30%, which is comparable to that of many malignancies. Yet despite standard wound care, only about 30%–40% of chronic DFUs achieve complete healing within 12 weeks. This persistent failure shows that conventional dressings remain passive supports. They do not counteract underlying pathologies such as ischemia, prolonged inflammation, and infection. Recent advances in polymeric nanofiber scaffolds, particularly electrospun matrices,… More > Graphic Abstract

Xiaolong Zhu, Feng Chen, Yuntian Chen, Wei Zhu, Xiaoxiao Han^*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.3, pp. 1-1, 2025, DOI:10.32604/icces.2025.012584

Abstract Human tissues and organs exhibit not only intricate anatomical architectures but also spatially heterogeneous distributions of elastic modulus—for example, between cancellous and cortical bone, across the epidermis, dermis, and subcutaneous layers, and between healthy and fibrotic liver tissues. Conventional biomaterials often fail to replicate such mechanical heterogeneity, thereby limiting their capacity to recreate biomimetic physiological microenvironments essential for applications like tissue regeneration and disease modeling. Meta-biomaterials, artificially engineered through the rational structural design of continuous materials, have emerged as a promising class of materials owing to their highly tunable mechanical and biological properties. These attributes… More >

Kaidi Luo¹, Weihuang Cai², Huazhen Liu¹, Yi Zhang², Kailei Pan², Xiaoyi Wang¹, Yuanyuan Liu^1,2*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.2, pp. 1-1, 2025, DOI:10.32604/icces.2025.011866

Abstract As the global prevalence of diabetes continues to rise, chronic diabetic wounds have become an important cause of amputation and death due to their protracted nature. In order to break through the limitations of traditional dressings, this study innovatively constructed a GelMA/HAMA-CS/PCL composite hydrogel-scaffold system containing chitosan based on biomaterials engineering and 3D printing technology. The system provides biomimetic ECM microenvironment through: photocrosslinked hydrogel layer (GelMA/HAMA-CS); Electrostatic spinning PCL film achieves mechanical strengthening and barrier protection. The chitosan component imparts long-term antibacterial activity, and the multi-materials cooperate to promote wound healing. In vitro antibacterial and… More >

Chong Wang^*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.1, pp. 1-1, 2025, DOI:10.32604/icces.2025.012164

Abstract Please Creating mechanically robust tissue engineering scaffolds capable of delivering growth factors and stem cells in situ for hard tissue repair remains a significant challenge. Inspired by the spiral structure of ice cream, our group developed an advanced 3D printing technique known as cryogenic 3D printing to fabricate polyester-based scaffolds with embedded growth factors. This method utilizes water-in-oil (w/o) polyester emulsions containing growth factors as the printing ink, which is patterned onto a cryogenic substrate. The resulting scaffolds feature a hierarchically porous structure, allowing mesenchymal stem cells (MSCs) to easily attach and proliferate. Additionally, the… More >

Hsien-Tsung Lu^1,2, Ching-Chi Hsu^3,*, Qi-Quan Jian³, Wei-Ting Chen⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.2, pp. 1883-1898, 2025, DOI:10.32604/cmes.2025.057675 - 27 January 2025

Abstract Reconstruction of a traumatic distal femur defect remains a therapeutic challenge. Bone defect implants have been proposed to substitute the bone defect, and their biomechanical performances can be analyzed via a numerical approach. However, the material assumptions for past computational human femur simulations were mainly homogeneous. Thus, this study aimed to design and analyze scaffolds for reconstructing the distal femur defect using a patient-specific finite element modeling technique. A three-dimensional finite element model of the human femur with accurate geometry and material distribution was developed using the finite element method and material mapping technique. An… More > Graphic Abstract

Ziying Zhang^1,*, Chu Li¹, Junwei Zhu¹, Qinghong Wu¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.31, No.1, pp. 1-1, 2024, DOI:10.32604/icces.2024.010912

Abstract The process of perfusion seeding of cells into a porous scaffold represents a pivotal initial stage in the development of tissue-engineered bones. The rheological behavior of the cell suspension plays a crucial role in influencing the transport and distribution of cells within the scaffold. Currently, there is limited understanding of the non-Newtonian rheology of cell suspensions in complex pores which differs significantly from simple channels or linear shear flow. In this study, we utilize our previously developed mesoscopic model of perfusion cell seeding to investigate the rheological behavior of cell suspensions at the cellular scale. More >

Haowen Liang¹, Jiaming Bai^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.012563

Abstract Defects are pivotal in influencing the mechanical performance of the hydroxyapatite (HAp) porous structure. In vat photopolymerization (VP) fabrication, directly peeling HAp/polymer green structure from the platform is an efficient approach but often introduces defects, compromising the mechanical performance of sintered HAp scaffolds. The peeling process is a physical phenomenon where the photocured HAp/polymer green structure exhibits resistance against applied peeling forces, which is influenced by its modulus and toughness. In this study, the peeling behavior of cubic-pore HAp (CP-HAp) green structures with varying levels of modulus and toughness was investigated in detail. The characterization… More >

Dmitry Bratsun^*, Natalia Elenskaya, Ramil Siraev, Mikhail Tashkinov

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.7, pp. 1463-1479, 2024, DOI:10.32604/fdmp.2024.047928 - 23 July 2024

Abstract In this work, we numerically study the hydrodynamic permeability of new-generation artificial porous materials used as scaffolds for cell growth in a perfusion bioreactor. We consider two popular solid matrix designs based on triply periodic minimal surfaces, the Schwarz P (primitive) and D (diamond) surfaces, which enable the creation of materials with controlled porosity gradients. The latter property is crucial for regulating the shear stress field in the pores of the scaffold, which makes it possible to control the intensity of cell growth. The permeability of functionally graded materials is studied within the framework of… More > Graphic Abstract

ZEHRA GÜL MORÇIMEN¹, ŞEYMA TAŞDEMIR², AYLIN ŞENDEMIR^3,4,*

BIOCELL, Vol.48, No.1, pp. 79-96, 2024, DOI:10.32604/biocell.2023.045361 - 30 January 2024

Abstract Neurodegeneration is a catastrophic process that develops progressive damage leading to functional and structural loss of the cells of the nervous system and is among the biggest unavoidable problems of our age. Animal models do not reflect the pathophysiology observed in humans due to distinct differences between the neural pathways, gene expression patterns, neuronal plasticity, and other disease-related mechanisms in animals and humans. Classical in vitro cell culture models are also not sufficient for pre-clinical drug testing in reflecting the complex pathophysiology of neurodegenerative diseases. Today, modern, engineered techniques are applied to develop multicellular, intricate in vitro More >