Haowen Liang¹, Jiaming Bai^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.012563

Abstract Defects are pivotal in influencing the mechanical performance of the hydroxyapatite (HAp) porous structure. In vat photopolymerization (VP) fabrication, directly peeling HAp/polymer green structure from the platform is an efficient approach but often introduces defects, compromising the mechanical performance of sintered HAp scaffolds. The peeling process is a physical phenomenon where the photocured HAp/polymer green structure exhibits resistance against applied peeling forces, which is influenced by its modulus and toughness. In this study, the peeling behavior of cubic-pore HAp (CP-HAp) green structures with varying levels of modulus and toughness was investigated in detail. The characterization… More >

Dmitry Bratsun^*, Natalia Elenskaya, Ramil Siraev, Mikhail Tashkinov

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.7, pp. 1463-1479, 2024, DOI:10.32604/fdmp.2024.047928 - 23 July 2024

Abstract In this work, we numerically study the hydrodynamic permeability of new-generation artificial porous materials used as scaffolds for cell growth in a perfusion bioreactor. We consider two popular solid matrix designs based on triply periodic minimal surfaces, the Schwarz P (primitive) and D (diamond) surfaces, which enable the creation of materials with controlled porosity gradients. The latter property is crucial for regulating the shear stress field in the pores of the scaffold, which makes it possible to control the intensity of cell growth. The permeability of functionally graded materials is studied within the framework of… More > Graphic Abstract

ZEHRA GÜL MORÇIMEN¹, ŞEYMA TAŞDEMIR², AYLIN ŞENDEMIR^3,4,*

BIOCELL, Vol.48, No.1, pp. 79-96, 2024, DOI:10.32604/biocell.2023.045361 - 30 January 2024

Abstract Neurodegeneration is a catastrophic process that develops progressive damage leading to functional and structural loss of the cells of the nervous system and is among the biggest unavoidable problems of our age. Animal models do not reflect the pathophysiology observed in humans due to distinct differences between the neural pathways, gene expression patterns, neuronal plasticity, and other disease-related mechanisms in animals and humans. Classical in vitro cell culture models are also not sufficient for pre-clinical drug testing in reflecting the complex pathophysiology of neurodegenerative diseases. Today, modern, engineered techniques are applied to develop multicellular, intricate in vitro More >

Jinshuo Wang, Lida Xing, Fulong Zhang, Chuanfu Liu^*

Journal of Renewable Materials, Vol.12, No.1, pp. 89-102, 2024, DOI:10.32604/jrm.2023.029057 - 23 January 2024

Abstract Wood-based functional materials have developed rapidly. But the flammability significantly limits its further application. To improve the flame retardancy, the balsa wood was delignified by NaClO₂ solution to create a cellulose scaffold, and then alternately immersed in CaCl₂ ethanol solution and NaHCO₃ aqueous solution under vacuum. The high porosity and wettability resulting from delignification benefited the following mineralization process, changing the thermal properties of balsa wood significantly. The organic-inorganic wood composite showed abundant CaCO₃ spherical particles under scanning electron microscopy. The peak of the heat release rate of delignified balsa-CaCO₃ was reduced by 33% compared to the native More > Graphic Abstract

MINJI PARK¹, CHULHWAN BANG², WON-SOO YUN³, YUN-MI JEONG^3,*

Oncology Research, Vol.32, No.2, pp. 273-282, 2024, DOI:10.32604/or.2023.044362 - 28 December 2023

Abstract Fucoidan, a sulfate polysaccharide obtained from brown seaweed, has various bioactive properties, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidant, anti-coagulant, anti-thrombotic, anti-angiogenic, and anti-Helicobacter pylori properties. However, the effects of low-molecular-weight fucoidan (LMW-F) on melanoma cell lines and three dimensional (3D) cell culture models are not well understood. This study aimed to investigate the effects of LMW-F on A375 human melanoma cells and cryopreserved biospecimens derived from patients with advanced melanoma. Ultrasonic wave was used to fragment fucoidan derived from Fucus vesiculosus into smaller LMW-F. MTT and live/dead assays showed that LMW-F inhibited cell proliferation in both A375 cells More >

SOBHA KOTA^*, RATNAKUMARI ANANTHA, VAYUNANDANA RAO GOVADA, PRADEEP DUMPALA

Journal of Polymer Materials, Vol.40, No.3-4, pp. 285-303, 2023, DOI:10.32381/JPM.2023.40.3-4.10

Abstract The exoskeleton of marine shrimp contains a natural, biocompatible polymer chitin, which is dumped as a waste. The study proposes the sustainable single-pot-extraction of chitosan from the waste and its use in the fabrication of wound-dressings, and thus leverage its piezoelectric, antioxidant, hypoglycaemic and medicinal properties in wound-healing. The Fourier transform infrared spectrum revealed that marine chitosan contains functional groups with N-O, O-H, and CO stretching. Scanning electron micrographs demonstrated the spherical and mesoporous structures of the extracted chitosan. X-ray diffraction analysis showed a semi-crystalline phase of chitosan particles with a mean size of 28.9… More >

LAURA MARRONE¹, MASSIMO D’AGOSTINO¹, CAROLINA GIORDANO², VALERIA DI GIACOMO¹, SIMONA URZINI¹, CHIARA MALASOMMA¹, MARIA PAOLA GAMMELLA¹, MARTINA TUFANO¹, SIMONA ROMANO^1,*, MARIA FIAMMETTA ROMANO^1,*

Oncology Research, Vol.31, No.4, pp. 423-436, 2023, DOI:10.32604/or.2023.028392 - 25 June 2023

Abstract Scaffold proteins are crucial regulators of signaling networks, and their abnormal expression may favor the development of tumors. Among the scaffold proteins, immunophilin covers a unique role as ‘protein-philin’ (Greek ‘philin’ = friend) that interacts with proteins to guide their proper assembly. The growing list of human syndromes associated with the immunophilin defect underscores the biological relevance of these proteins that are largely opportunistically exploited by cancer cells to support and enable the tumor’s intrinsic properties. Among the members of the immunophilin family, the FKBP5 gene was the only one identified to have a splicing variant. More > Graphic Abstract

AAYUSHI RANDHAWA^1,2, SAYAN DEB DUTTA¹, KEYA GANGULY¹, TEJAL V. PATIL^1,2, RACHMI LUTHFIKASARI¹, KI-TAEK LIM^1,2,*

BIOCELL, Vol.47, No.4, pp. 789-808, 2023, DOI:10.32604/biocell.2023.026217 - 08 March 2023

Abstract Tissues are made up of cells and the extracellular matrix (ECM) which surrounds them. These cells and tissues are actively adaptable to enduring significant stress that occurs in daily life. This astonishing mechanical stress develops due to the interaction between the live cells and the non-living ECM. Cells in the matrix microenvironment can sense the signals and forces produced and initiate a signaling cascade that plays a crucial role in the body’s normal functioning and influences various properties of the native cells, including growth, proliferation, and differentiation. However, the matrix’s characteristic features also impact the More >

Soliman Abdalla^1,2,*, Shiref Kandil²

Journal of Renewable Materials, Vol.10, No.11, pp. 2699-2716, 2022, DOI:10.32604/jrm.2022.022334 - 29 June 2022

Abstract In order to obtain larger, clinical-scale and practical-scale bone grafts, we have designed both tailored scaffolds and tailored bio incubator with optimal bio-production characteristics. Using DIC files to Simpleware Scan-IP (Simple-ware-exeter United Kingdom), we have digitally reconstructed segmental additive bone-tissue in order to perform images processing. Both hydroxyapatite and tannin composites have been used in order to get the final bone modules combined for retexturing of segmental bone defect. We have found that sectioning of bone segment deficiency reorganizations into well disk-shaped design permits one to standardize the cell culture and seeding protocol, to get More >

FABIANO BINI^1,*, ANDRADA PICA¹, ANDREA MARINOZZI², FRANCO MARINOZZI¹

BIOCELL, Vol.46, No.10, pp. 2225-2229, 2022, DOI:10.32604/biocell.2022.021150 - 13 June 2022

Abstract Bone tissue is a hierarchical material characterized at nanoscale by the mineralized collagen fibril, a recurring structure mainly composed of apatite minerals, collagen and water. Bone nanostructure has a fundamental role in determining the mechanical behavior of the tissue and its mass transport properties. Diffusion phenomenon allows to maintain an adequate supply of metabolites in the mechanisms of bone remodeling, adaptation and repair. Several analytical and computational models have been developed to analyze and predict bone tissue behavior. However, the fine replication of the natural tissue still represents a challenge. Insights on the structural organization More >