LUIS MANUEL GONZáLEZ-RODRíGUEZ1, LUIS MIGUEL JUáREZ-SALCEDO1,*, JAVIER LOSCERTALES1, EVA ARRANZ1, JIMENA CANNATA-ORTIZ1, JAVIER ORTIZ1, MARIA JOSé LóPEZ DE LA OSA1, ADRIáN ALEGRE1, SAMIR DALIA2,*
Oncology Research, Vol.33, No.3, pp. 505-517, 2025, DOI:10.32604/or.2025.058175
- 28 February 2025
Abstract T-prolymphocytic leukemia is a rare and aggressive hematological malignancy characterized by the clonal proliferation of mature lymphoid T-cells. The pathogenesis of T-PLL is closely linked to specific chromosomal abnormalities, primarily involving the proto-oncogene T-cell leukemia/lymphoma 1 gene family. Recent advancements in molecular profiling have identified additional genomic aberrations, including those affecting the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway. This case report presents a patient with T-prolymphocytic leukemia whose cytogenetic and molecular analysis revealed a t(X;14)(q28;q11.2) translocation and a STAT5B mutation. Here, we aim to review the genetic and molecular underpinnings of T-prolymphocytic More >
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