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  • Open Access

    ARTICLE

    Analysis of Annual Rainfall and Annual Number of Rainy Days in the Research for Indices of Climate Change in the Zambezian Phytogeographic Region

    N’Landu Dikumbwa1,*, Scott Tshibang Nawej2, Gabriel Mutundo Teteka2, Benjamin Mayaka Kibwila3, Jules Aloni Komanda3

    Revue Internationale de Géomatique, Vol.35, pp. 13-30, 2026, DOI:10.32604/rig.2026.068019 - 05 February 2026

    Abstract Rainfall data from four weather stations, quite far from each other, but located in the Zambezian phytogeographic region, were analysed for the research for indices of climate change. Two variables, rainfall and the annual number of rainy days, were considered. The rainfall data examined are 114 years for Luanda (1901–2014), 106 years for Lubumbashi (1916–2021), respectively, 54 and 41 years for Huambo (1961–2014) and Boma (1981–2021); 100 years (1921–2021) for the annual number of rainy days for only the Lubumbashi weather station. The results were a widespread decline in rainfall at all weather stations. Despite… More >

  • Open Access

    ARTICLE

    Real-Time Mouth State Detection Based on a BiGRU-CLPSO Hybrid Model with Facial Landmark Detection for Healthcare Monitoring Applications

    Mong-Fong Horng1,#, Thanh-Lam Nguyen1,#, Thanh-Tuan Nguyen2,*, Chin-Shiuh Shieh1,*, Lan-Yuen Guo3, Chen-Fu Hung4, Chun-Chih Lo1

    CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.1, 2026, DOI:10.32604/cmes.2025.075064 - 29 January 2026

    Abstract The global population is rapidly expanding, driving an increasing demand for intelligent healthcare systems. Artificial intelligence (AI) applications in remote patient monitoring and diagnosis have achieved remarkable progress and are emerging as a major development trend. Among these applications, mouth motion tracking and mouth-state detection represent an important direction, providing valuable support for diagnosing neuromuscular disorders such as dysphagia, Bell’s palsy, and Parkinson’s disease. In this study, we focus on developing a real-time system capable of monitoring and detecting mouth state that can be efficiently deployed on edge devices. The proposed system integrates the Facial… More >

  • Open Access

    ARTICLE

    Bias Calibration under Constrained Communication Using Modified Kalman Filter: Algorithm Design and Application to Gyroscope Parameter Error Calibration

    Qi Li, Yifan Wang*, Yuxi Liu, Xingjing She, Yixuan Wu

    CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.1, 2026, DOI:10.32604/cmes.2025.074066 - 29 January 2026

    Abstract In data communication, limited communication resources often lead to measurement bias, which adversely affects subsequent system estimation if not effectively handled. This paper proposes a novel bias calibration algorithm under communication constraints to achieve accurate system states of the interested system. An output-based event-triggered scheme is first employed to alleviate transmission burden. Accounting for the limited-communication-induced measurement bias, a novel bias calibration algorithm following the Kalman filtering line is developed to restrain the effect of the measurement bias on system estimation, thereby achieving accurate system state estimates. Subsequently, the Field Programmable Gate Array (FPGA) implementation More >

  • Open Access

    ARTICLE

    Predictive Maintenance Strategy for Photovoltaic Power Systems: Collaborative Optimization of Transformer-Based Lifetime Prediction and Opposition-Based Learning HHO Algorithm

    Wei Chen, Yang Wu*, Tingting Pei, Jie Lin, Guojing Yuan

    Energy Engineering, Vol.123, No.2, 2026, DOI:10.32604/ee.2025.070905 - 27 January 2026

    Abstract In view of the insufficient utilization of condition-monitoring information and the improper scheduling often observed in conventional maintenance strategies for photovoltaic (PV) modules, this study proposes a predictive maintenance (PdM) strategy based on Remaining Useful Life (RUL) estimation. First, a RUL prediction model is established using the Transformer architecture, which enables the effective processing of sequential degradation data. By employing the historical degradation data of PV modules, the proposed model provides accurate forecasts of the remaining useful life, thereby supplying essential inputs for maintenance decision-making. Subsequently, the RUL information obtained from the prediction process is… More >

  • Open Access

    REVIEW

    Cancer-Associated Fibroblasts in Prostate Cancer: Unraveling Mechanisms and Therapeutic Implications

    Yang Wu1,#,*, Dong Xu1,#, Run Shi1, Mingwei Zhan2, Shaohui Xu3, Xin Wang4, Jianpeng Zhang5, Zhaokai Zhou6, Weizhuo Wang7, Yongjie Wang8, Minglun Li9, Zihao Xu10,*, Kaifeng Su11,*

    Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.073265 - 19 January 2026

    Abstract Prostate cancer (PCa) remains a major cause of cancer-related mortality in men, largely due to therapy resistance and metastatic progression. Increasing evidence highlights the tumor microenvironment (TME), particularly cancer-associated fibroblasts (CAFs), as a critical determinant of disease behavior. CAFs constitute a heterogeneous population originating from fibroblasts, mesenchymal stem cells, endothelial cells, epithelial cells undergoing epithelial–mesenchymal transition (EMT), and adipose tissue. Through dynamic crosstalk with tumor, immune, endothelial, and adipocyte compartments, CAFs orchestrate oncogenic processes including tumor proliferation, invasion, immune evasion, extracellular matrix remodeling, angiogenesis, and metabolic reprogramming. This review comprehensively summarizes the cellular origins, phenotypic More >

  • Open Access

    ARTICLE

    Gut Associated Metabolites Enhance PD-L1 Blockade Efficacy in Prostate Cancer

    Ke Liu1,2,3,#, Xia Xue1,2,3,#, Haiming Qin4,5,#, Jiaying Zhu6,#, Meng Jin1,6, Die Dai6, Youcai Tang1, Ihtisham Bukhari1, Hangfan Liu1, Chunjing Qiu1, Feifei Ren1, Pengyuan Zheng1,2,3, Yang Mi1,2,3,*, Weihua Chen6,7,*

    Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.072661 - 19 January 2026

    Abstract Background: The gut microbiome has emerged as a critical modulator of cancer immunotherapy response. However, the mechanisms by which gut-associated metabolites influence checkpoint blockade efficacy in prostate cancer (PC) remain not fully explored. The study aimed to explore how gut metabolites regulate death-ligand 1 (PD-L1) blockade via exosomes and boost immune checkpoint inhibitors (ICIs) in PC. Methods: We recruited 70 PC patients to set up into five subgroups. The integrated multi-omics analysis was performed. In parallel, we validated the function of gut microbiome-associated metabolites on PD-L1 production and immunotherapy treatment efficacy in PC cell lines… More >

  • Open Access

    REVIEW

    Clinical Molecular Pathology and Treatment Developments in Advanced Uveal Melanoma: State of the Art

    Stefano Dore1, Matteo Sacchi1, Antonio Pinna1, Giuseppe Palmieri2,3, Panagiotis Paliogiannis4,*

    Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.071831 - 19 January 2026

    Abstract Uveal melanoma (UM) is the most common intraocular cancer, with approximately 5.2 individuals per million affected annually in the United States. It represents approximately 3% of the global malignant melanoma cases, accounting for 80% of the overall noncutaneous melanomas. Clinically, it remains silent in about 30% of the cases; when symptomatic, it generally causes metamorphopsia (painless loss or distortion of vision) and/or photopsia (flashing or flickering of light in the visual field). Discoloration of the iris, astigmatism, glaucoma, and even blindness are other, less common clinical manifestations. Several pathophysiological mechanisms underlie the development of UM.… More >

  • Open Access

    ARTICLE

    Prognostic Value of Circulating Tumor Cells and Cancer Associated Macrophage-Like Cells in Metastatic Non-Small Cell Lung Cancer Patients: A Retrospective Exploratory Analysis

    Marco Siringo1,2,#,*, Michela De Meo1,#, Alain Jonathan Gelibter3, Chiara Nicolazzo4,5,§, Paola Gazzaniga5,§

    Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.069832 - 19 January 2026

    Abstract Objectives: Although immune checkpoint inhibitors (ICIs) and targeted therapies have reshaped treatment non-small cell lung cancer (NSCLC) paradigms, prognosis remains poor for many patients due to delayed diagnosis and resistance mechanisms. Liquid biopsy offers a minimally invasive approach to monitoring tumor evolution. Among circulating biomarkers, circulating tumor cells (CTCs) and cancer-associated macrophage-like cells (CAM-Ls) may provide complementary prognostic insights. The study aimed to evaluate the prognostic role of CTC and CAM-Ls dynamic in metastatic NSCLC patients. Methods: We retrospectively analyzed 77 patients with metastatic NSCLC who underwent CTC and CAM-L evaluation via the CellSearch® system… More >

  • Open Access

    CASE REPORT

    Detection of Prostate Carcinoma in an Asymptomatic Individual Initiated by an Immunological Biopsy—A Case Report

    Simon Burg1, Audrey Laure Céline Grust1,2,*

    Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.068555 - 19 January 2026

    Abstract Background: With a total of 1.46 million new cases and 396,792 deaths in 2022, prostate cancer is a major medical challenge around the world. Detecting and treating cancer at earlier, preferably localized stages can significantly increase survival rates. Here, a novel blood-based cancer screening as a pre-test in combination with targeted MRI imaging enabled the early diagnosis of prostate cancer. Case Description: We present the case of a 64-year-old man who participated in a prospective, interventional, multicenter cancer screening study where an immunological biopsy-based technique served as a part of a novel screening technique. This immunology… More >

  • Open Access

    CASE REPORT

    Rare Multiple Brain Metastases Following Debulking Surgery and Androgen Deprivation Therapy in Aggressive Prostate Cancer-Case Report

    Andong Cheng1,2,#, Yiding Chen1,#, Hao Li1, Feixiang Yang1, Junlan Jiang3, Sheng Tai1, Weiwei Chen4, Yu Guan1, Shuiping Yin1,*, Jialin Meng1,2,*

    Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.066478 - 19 January 2026

    Abstract Background: In clinical practice, approximately 80% of prostate cancer (PC) cases are localized and can achieve favorable outcomes with appropriate treatment. Conversely, some remaining cases exhibit an aggressive phenotype or develop resistance to therapeutic interventions, leading to tumor metastasis and a poorer prognosis. When PC metastasizes to distant sites, the bone remains the predominant location, and brain metastases are regarded as exceedingly rare. Case Description: The current study focused on a rare clinical PC case that presented multiple brain metastases after prostate surgery. The patient was initially diagnosed with PC through prostate biopsy and subsequently underwent More >

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