CHUAN JIANG^1,2, CHUNLEI LIU^1,3, XI YAO^1,3, JINGYA SU^1,2, WEI LU^1,3, ZHENGBO WEI^3,*, YING XIE^1,2,*

Oncology Research, Vol.32, No.12, pp. 1935-1948, 2024, DOI:10.32604/or.2024.052244 - 13 November 2024

Abstract Background: Head and neck squamous cell carcinoma (HNSCC) is a prevalent form of cancer globally, with chemoresistance posing a major challenge in treatment outcomes. The efficacy of the commonly used chemotherapeutic agent, cisplatin, is diminished in patients with poor prognoses. Methods: Various bioinformatics databases were utilized to examine Carboxylesterase 1 (CES1) gene expression, clinicopathologic features, patient survival analysis, and gene function. An organoid model of HNSCC was established, along with the induction of drug-resistant HNSCC in the organoid model. CES1 expression was assessed using qRT-PCR and Western Blot, and differential markers were identified through transcriptome… More >

ZEYIN LAI¹, HANGYUAN ZHAO¹, HONG DENG^1,2,*

BIOCELL, Vol.48, No.11, pp. 1569-1578, 2024, DOI:10.32604/biocell.2024.053983 - 07 November 2024

Abstract In the development of colorectal cancer (CRC), cancer-associated fibroblasts (CAFs) play a pivotal role in establishing tumor-permissive extracellular matrix structures, angiogenesis, and modulating the immune status of the tumor microenvironment (TME), thereby influencing tumor metastasis and resistance to radiotherapy and chemotherapy. The pleiotropic effects of CAFs in the TME may be attributed to the heterogeneous origin and high plasticity of their population. Given the specificity of CAFs, they provide a variety of potential target molecules for future CRC treatment, which may play an indispensable role in CRC therapeutic strategies. This review summarizes the origin of More >

Ruiqi Pan¹, Wei Xiong², Liang Hao^1,*, Yan Li^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.011651

Abstract As metal additive manufacturing (MAM) becomes more widely used in engineering, an increasing number of novel lattice structures are being developed. However, most recently developed lattice structures do not match the requirement of MAM efficiently. Based on the Design for Additive Manufacturing (DfAM), comparing the mainstream implicit and explicit modelling methods, it is proposed to introduce a Subdivisional (Sub-D) modelling method to model lattice structures with better modelling versatility, 3D printability, and mechanical properties. To this end, a novel negative Poisson's ratio (NPR) structure is developed as an example to demonstrate the efficient and wide… More >

Jeong Min Yang¹, Ji Sung Hong¹, Jae Hyun Kim^2,*

International Journal of Mental Health Promotion, Vol.26, No.10, pp. 791-803, 2024, DOI:10.32604/ijmhp.2024.056433 - 31 October 2024

Abstract Background: This study conducted a longitudinal analysis of the association between job satisfaction and stress or depressive symptoms of employed persons with disabilities (PWDs) based on the data from the 1st to 8th Pannel Survey of Employment for the Disabled (PSED). Methods: After excluding missing values, data on 1614 participants at baseline (1st wave) were analyzed using the chi-square test and generalized estimating equation (GEE) model for data from 1st to 8thPSED. Results: It was found that for each one-unit increase in the job satisfaction score, the stress scale decreased by 0.004 (B: −0.004, 95% CI:… More >

Dojin An¹, Nguyen Hoang Minh Thuan², Youngho Kim^1,*

International Journal of Mental Health Promotion, Vol.26, No.10, pp. 847-853, 2024, DOI:10.32604/ijmhp.2024.055568 - 31 October 2024

Abstract Background: In contemporary society, it has been widely witnessed that a surprising number of adolescents suffer emotional and mental health problems, and such turmoil is very often carried over into adulthood with serious implications for adjustment during the post-adolescent years. The purpose of the current study is to investigate the associations of physical activity with self-esteem, depression, and suicidal ideation. In addition, this study examined whether self-esteem and depression mediate the relationship between physical activity and suicide ideation in adolescents. Methods: The study participants were 946 (male: 527, female: 419) who attended junior high and… More >

Sejin Choi^1,2, Ho-Seok Lee^1,2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.10, pp. 2519-2534, 2024, DOI:10.32604/phyton.2024.058012 - 30 October 2024

Abstract Plants interact with a complex network of microorganisms, forming a dynamic holobiont that is crucial for their health, growth, and adaptation. This interconnected system is deeply influenced by environmental factors, which modulate the relationships within the plant microbiome. Key environmental drivers such as light, temperature, and moisture can alter the balance of these interactions, impacting plant immunity, resilience, and overall fitness. The traditional disease triangle model, which emphasizes plant-pathogen-environment interactions, is enhanced by incorporating the role of the microbiome, revealing how microbial communities contribute to disease outcomes. This review highlights the importance of shifting focus More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.11, pp. 1825-1825, 2024, DOI:10.32604/or.2024.056897 - 16 October 2024

Abstract This article has no abstract. More >

LICHEN XU^1,2, PAN ZHANG^3,*, GUIQI ZHANG², ZHAOLIANG SHEN⁴, XIZHUANG BAI^1,3,*

Oncology Research, Vol.32, No.11, pp. 1777-1789, 2024, DOI:10.32604/or.2024.047704 - 16 October 2024

Abstract Background: Osteosarcoma (OS), recognized as the predominant malignant tumor originating from bones, necessitates an in-depth comprehension of its intrinsic mechanisms to pinpoint novel therapeutic targets and enhance treatment methodologies. The role of fat mass and obesity-associated (FTO) in OS, particularly its correlation with malignant traits, and the fundamental mechanism, remains to be elucidated. Materials and Methods: 1. The FTO expression and survival rate in tumors were analyzed. 2. FTO in OS cell lines was quantified utilizing western blot and PCR. 3. FTO was upregulated and downregulated separately in MG63. 4. The impact of FTO on the… More >

YONGJIAN HUANG, JINZHOU WANG, JIUHUA XU, NING RUAN^*

Oncology Research, Vol.32, No.11, pp. 1765-1776, 2024, DOI:10.32604/or.2024.045564 - 16 October 2024

Abstract Background: Despite significant advancements in the development of anticancer therapies over the past few decades, the clinical management of colorectal cancer remains a challenging task. This study aims to investigate the inhibitory effects of cancer-targeting liposomes against colorectal cancer. Materials and Methods: Liposomes consisting of 3β-[N-(N′, N′-dimethylamino ethane)carbamoyl]-cholesterol (DC-CHOL), cholesterol (CHOL), and dioleoylphosphatidylethanolamine (DOPE) at a molar ratio of 1:1:0.5 were created and used as carriers to deliver an apoptosis-inducing plasmid encoding the tumor necrosis factor-related apoptosis-inducing ligand (pTRAIL) gene, along with the toll-like receptor (TLR7) agonist Rsiquimod (R848). The rationale behind this design is that More > Graphic Abstract

Suya Li¹, Ying Cao^1,*, Hengyi Ren², Dongsheng Zhu³, Xin Xie¹

CMC-Computers, Materials & Continua, Vol.81, No.1, pp. 1449-1470, 2024, DOI:10.32604/cmc.2024.056824 - 15 October 2024

Abstract Multi-object tracking (MOT) has seen rapid improvements in recent years. However, frequent occlusion remains a significant challenge in MOT, as it can cause targets to become smaller or disappear entirely, resulting in low-quality targets, leading to trajectory interruptions and reduced tracking performance. Different from some existing methods, which discarded the low-quality targets or ignored low-quality target attributes. LQTTrack, with a low-quality association strategy (LQA), is proposed to pay more attention to low-quality targets. In the association scheme of LQTTrack, firstly, multi-scale feature fusion of FPN (MSFF-FPN) is utilized to enrich the feature information and assist… More >