Yuyang Nie^1,2,#, Kunkun Jiang^2,3,#, Tianci Wang⁴, Cong Liu^1,2, Kangli Du^1,2, Yuxian Cao², Guofeng Qu^2,*, Lijia Hou^2,*

International Journal of Mental Health Promotion, Vol.28, No.1, 2026, DOI:10.32604/ijmhp.2025.073592 - 28 January 2026

Abstract Background: Amid the global rise in adolescent sedentary behavior and psychological distress, extant research has largely focused on variable-level associations, neglecting symptom-level interactions. This study applies network analysis, aims to delineate the interconnections among sedentary time, social support, social exclusion, and psychological distress in Chinese students, and to identify core and bridge symptoms to inform targeted interventions. Methods: This study employed a cross-sectional design to investigate the complex relationships among sedentary behavior, social support, social exclusion, and psychological distress among Chinese students. The research involved 459 high school and university students, using network analysis and mediation… More >

Abdulaziz Almalaq¹, Ambe Harrison^2,*, Ibrahim Alsaleh¹, Abdullah Alassaf¹, Mashari Alangari¹

CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.1, 2026, DOI:10.32604/cmes.2025.074815 - 29 January 2026

Abstract We present a computer-modeling framework for photovoltaic (PV) source emulation that preserves the exact single-diode physics while enabling iteration-free, real-time evaluation. We derive two closed-form explicit solvers based on the Lambert W function: a voltage-driven V-Lambert solver for high-fidelity I–V computation and a resistance-driven R-Lambert solver designed for seamless integration in a closed-loop PV emulator. Unlike Taylor-linearized explicit models, our proposed formulation retains the exponential nonlinearity of the PV equations. It employs a numerically stable analytical evaluation that eliminates the need for lookup tables and root-finding, all while maintaining limited computational costs and a small… More >

Cheng Yang^*, Hanjie Qi, Qing Yin

Energy Engineering, Vol.123, No.2, 2026, DOI:10.32604/ee.2025.070957 - 27 January 2026

Abstract In order to enhance the off-peak performance of gas turbine combined cycle (GTCC) units, a novel collaborative power generation system (CPG) was proposed. During off-peak operation periods, the remaining power of the GTCC was used to drive the adiabatic compressed air energy storage (ACAES), while the intake air of the GTCC was heated by the compression heat of the ACAES. Based on a 67.3 MW GTCC, under specific demand load distribution, a CPG system and a benchmark system (BS) were designed, both of which used 9.388% of the GTCC output power to drive the ACAES.… More >

Douglas M. Ruden^*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.072273 - 23 January 2026

Abstract Stem cell fate decisions are increasingly understood through the dynamic interplay of two fundamental stress-adaptive programs: the integrated stress response (ISR) and the senescence-associated secretory phenotype (SASP). These pathways act as a Yin–Yang system, balancing beneficial and detrimental outcomes across development, tissue homeostasis, and disease. On the yin (protective) side, transient ISR activation and acute SASP signaling foster adaptation, embryonic patterning, wound healing, and regeneration. On the yang (maladaptive) side, chronic ISR signaling and unresolved SASP output drive stem cell exhaustion, fibrosis, inflammation, and tumorigenesis. This duality highlights their roles as both guardians and disruptors More > Graphic Abstract

TOSHIYUKI HABU^*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.071798 - 23 January 2026

Abstract RING protein 213 (RNF213), the susceptibility gene for Moyamoya disease (MMD), possesses two active AAA+ ATPase (ATPases Associated with diverse cellular Activities) modules, a RING, and RNF213-ZNFX1 finger (RZ finger) domains. Several RNF213 variants have been reported in MMD patients, including the p.R4810K variant (rs112735431), which is a founder polymorphism associated with MMD in East Asia. To elucidate the function of RNF213 and its variant, we investigated the localization of RNF213 and the R4810K variant in this study. RNF213 induced circular hole structures near the nucleus, similar to lipid droplets (LDs), in U-2 OS cells. More >

Hang Zhang^1,#, Meng-Yuan Chu^1,#, Guohui Lv¹, You-Jie Li¹, Xuhang Liu², Fei Jiao^1,*, Yun-Fei Yan^1,*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.068322 - 23 January 2026

Abstract Objectives: Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, with limited understanding of lncRNA-driven mechanisms in tumor progression. This study aimed to identify differentially expressed lncRNAs in NSCLC tissues and elucidate the functional role of the significantly upregulated RP3-340N1.2 in promoting malignancy. Methods: RNA sequencing was used to screen dysregulated lncRNAs. RP3-340N1.2 was functionally characterized via gain/loss-of-function assays in NSCLC cells, assessing proliferation, migration, and macrophage polarization. Mechanisms of interleukin 6 (IL-6) regulation were explored using cytokine profiling, Actinomycin D assays, and RNA Immunoprecipitation (RIP) assays to study RP3-340N1.2 interactions with… More >

Yang Wu^1,#,*, Dong Xu^1,#, Run Shi¹, Mingwei Zhan², Shaohui Xu³, Xin Wang⁴, Jianpeng Zhang⁵, Zhaokai Zhou⁶, Weizhuo Wang⁷, Yongjie Wang⁸, Minglun Li⁹, Zihao Xu^10,*, Kaifeng Su^11,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.073265 - 19 January 2026

Abstract Prostate cancer (PCa) remains a major cause of cancer-related mortality in men, largely due to therapy resistance and metastatic progression. Increasing evidence highlights the tumor microenvironment (TME), particularly cancer-associated fibroblasts (CAFs), as a critical determinant of disease behavior. CAFs constitute a heterogeneous population originating from fibroblasts, mesenchymal stem cells, endothelial cells, epithelial cells undergoing epithelial–mesenchymal transition (EMT), and adipose tissue. Through dynamic crosstalk with tumor, immune, endothelial, and adipocyte compartments, CAFs orchestrate oncogenic processes including tumor proliferation, invasion, immune evasion, extracellular matrix remodeling, angiogenesis, and metabolic reprogramming. This review comprehensively summarizes the cellular origins, phenotypic More >

Ke Liu^1,2,3,#, Xia Xue^1,2,3,#, Haiming Qin^4,5,#, Jiaying Zhu^6,#, Meng Jin^1,6, Die Dai⁶, Youcai Tang¹, Ihtisham Bukhari¹, Hangfan Liu¹, Chunjing Qiu¹, Feifei Ren¹, Pengyuan Zheng^1,2,3, Yang Mi^1,2,3,*, Weihua Chen^6,7,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.072661 - 19 January 2026

Abstract Background: The gut microbiome has emerged as a critical modulator of cancer immunotherapy response. However, the mechanisms by which gut-associated metabolites influence checkpoint blockade efficacy in prostate cancer (PC) remain not fully explored. The study aimed to explore how gut metabolites regulate death-ligand 1 (PD-L1) blockade via exosomes and boost immune checkpoint inhibitors (ICIs) in PC. Methods: We recruited 70 PC patients to set up into five subgroups. The integrated multi-omics analysis was performed. In parallel, we validated the function of gut microbiome-associated metabolites on PD-L1 production and immunotherapy treatment efficacy in PC cell lines… More >

Hyung Seok Kim^1,#, Ju A Son^2,#, Minji Kang^3,4,#, Soon Sun Kim³, Geum Ok Baek³, Moon Gyeong Yoon³, Se Ha Jang^3,4, Dokyung Jung⁵, Ji Eun Han³, Jae Youn Cheong^3,*, Jung Woo Eun^3,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.070392 - 19 January 2026

Abstract Objectives: Early detection of hepatocellular carcinoma (HCC) is a significant challenge due to the limited sensitivity of alpha-fetoprotein (AFP). This study aimed to assess serum-derived extracellular vesicle-encapsulated GULP PTB domain-containing engulfment adaptor 1 (EV-GULP1) as a novel, noninvasive biomarker for HCC detection and prognosis, leveraging the potential of tumor-specific molecules carried by small extracellular vesicles (EVs). Methods: The study utilized both internal and external cohorts of HCC patients and controls. Small EVs were isolated from serum samples, then characterized and validated to confirm their identity. The expression levels of EV-GULP1 were quantified using quantitative reverse transcription… More >

Marco Siringo^1,2,#,*, Michela De Meo^1,#, Alain Jonathan Gelibter³, Chiara Nicolazzo^4,5,§, Paola Gazzaniga^5,§

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.069832 - 19 January 2026

Abstract Objectives: Although immune checkpoint inhibitors (ICIs) and targeted therapies have reshaped treatment non-small cell lung cancer (NSCLC) paradigms, prognosis remains poor for many patients due to delayed diagnosis and resistance mechanisms. Liquid biopsy offers a minimally invasive approach to monitoring tumor evolution. Among circulating biomarkers, circulating tumor cells (CTCs) and cancer-associated macrophage-like cells (CAM-Ls) may provide complementary prognostic insights. The study aimed to evaluate the prognostic role of CTC and CAM-Ls dynamic in metastatic NSCLC patients. Methods: We retrospectively analyzed 77 patients with metastatic NSCLC who underwent CTC and CAM-L evaluation via the CellSearch® system… More >