WENLI ZENG1, FENG LING2, KAINUO DANG3, QINGJIA CHI3,*
BIOCELL, Vol.47, No.3, pp. 581-592, 2023, DOI:10.32604/biocell.2023.025957
- 03 January 2023
Abstract Hepatocellular carcinoma (HCC) is associated with poor prognosis and fluctuations in immune status.
Although studies have found that secreted phosphoprotein 1 (SPP1) is involved in HCC progression, its independent
prognostic value and immune-mediated role remain unclear. Using The Cancer Genome Atlas and Gene Expression
Omnibus data, we found that low expression of SPP1 is significantly associated with improved survival of HCC
patients and that SPP1 expression is correlated with clinical characteristics. Univariate and multivariate Cox
regression confirmed that SPP1 is an independent prognostic factor of HCC. Subsequently, we found that T cell CD4
memory-activated monocytes,… More >
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