Ibraheem Abu Falahah¹, Osama Al-Baik², Saleh Alomari³, Gulnara Bektemyssova⁴, Saikat Gochhait^5,6, Irina Leonova⁷, Om Parkash Malik⁸, Frank Werner^9,*, Mohammad Dehghani¹⁰

CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 3631-3678, 2024, DOI:10.32604/cmc.2024.053189

Abstract This research presents a novel nature-inspired metaheuristic algorithm called Frilled Lizard Optimization (FLO), which emulates the unique hunting behavior of frilled lizards in their natural habitat. FLO draws its inspiration from the sit-and-wait hunting strategy of these lizards. The algorithm’s core principles are meticulously detailed and mathematically structured into two distinct phases: (i) an exploration phase, which mimics the lizard’s sudden attack on its prey, and (ii) an exploitation phase, which simulates the lizard’s retreat to the treetops after feeding. To assess FLO’s efficacy in addressing optimization problems, its performance is rigorously tested on fifty-two… More >

Jingting Mei, Yang Yang^*, Zhipeng Gao, Lanlan Rui, Yijing Lin

CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 4883-4904, 2024, DOI:10.32604/cmc.2024.051860

Abstract Network fault diagnosis methods play a vital role in maintaining network service quality and enhancing user experience as an integral component of intelligent network management. Considering the unique characteristics of edge networks, such as limited resources, complex network faults, and the need for high real-time performance, enhancing and optimizing existing network fault diagnosis methods is necessary. Therefore, this paper proposes the lightweight edge-side fault diagnosis approach based on a spiking neural network (LSNN). Firstly, we use the Izhikevich neurons model to replace the Leaky Integrate and Fire (LIF) neurons model in the LSNN model. Izhikevich… More >

Weiwei Zhang¹, Jiaqiang Li¹, Chao Wang², Meng Li³, Zhi Rao^4,*

CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 4237-4257, 2024, DOI:10.32604/cmc.2024.050430

Abstract In practical engineering, multi-objective optimization often encounters situations where multiple Pareto sets (PS) in the decision space correspond to the same Pareto front (PF) in the objective space, known as Multi-Modal Multi-Objective Optimization Problems (MMOP). Locating multiple equivalent global PSs poses a significant challenge in real-world applications, especially considering the existence of local PSs. Effectively identifying and locating both global and local PSs is a major challenge. To tackle this issue, we introduce an immune-inspired reproduction strategy designed to produce more offspring in less crowded, promising regions and regulate the number of offspring in areas… More >

Jin Wang^*, Wenquan Pang^*, Zhenbai Zuo^*, Wenyan Zhang^*, Weidong He^†

Oncology Research, Vol.25, No.8, pp. 1297-1304, 2017, DOI:10.3727/096504017X14873430389189

Abstract Spinal osteosarcoma (OS) is a malignant tumor that has a poor outcome. MicroRNA-520b (miR-520b) acts as a cancer suppressor in various types of cancer. Because of the limited amount of literature on OS, we aimed to identify the role of miR-520b in OS. The miR-520b level in clinical spinal OS tissues and adjacent nontumor tissues as well as in cell lines was assessed. The effect of miR-520b on cell proliferation, migration, invasion, and frizzled-8 (FZD8) degradation were all evaluated. Alterations of key proteins involved in the Wnt/b-catenin pathway were assessed by Western blot analysis. In… More >

Yufeng Liu^*, Zhengliang Cheng^†, Feng Pan^‡, Weigang Yan^§

Oncology Research, Vol.25, No.6, pp. 989-999, 2017, DOI:10.3727/096504016X14813867762123

Abstract Spinal osteosarcoma (OS) has been proven to be more difficult to treat owing to potently malignant metastasis. The present study aimed to explore the functional role of microRNA (miR)-373 in cell growth and invasion of OS cells, as well as its underlying mechanism. The expression of miR-373 was analyzed in spinal OS tissues and cell lines. MG-63 cells were transfected with the miR-373 mimic or inhibitor and/or treated with the phosphoinositide 3-kinase (PI3K) (LY294002) inhibitor or Ras-related C3 botulinum toxin substrate 1 (Rac) guanosine triphosphate (GTPase) (NSC23766) inhibitor, and then the impact of miR-373 aberrant… More >

Yan Zhang, Gang Cao, Qing-gong Yuan, Jun-hui Li, Wen-Bin Yang

Oncology Research, Vol.25, No.4, pp. 537-544, 2017, DOI:10.3727/096504016X14756640150695

Abstract Empty spiracles homeobox 2 (EMX2) is a homeodomain-containing transcription factor that plays an essential role in tumorigenesis. However, to the best of our knowledge, the role of EMX2 in human colorectal cancer (CRC) is still unclear. Thus, the aim of this study was to investigate the expression and role of EMX2 in CRC. Our results demonstrated that the expression of EMX2 was greatly decreased in CRC tissues and cell lines. Overexpression of EMX2 significantly inhibited the proliferation in vitro and CRC tumor growth in nude mice. In addition, EMX2 also inhibited the migration and invasion More >

Xuesong Wang^*, Yong Lin^†, Lei Peng^‡, Ruifu Sun^*, Xiaojin Gong^*, Jinlong Du^*, Xiugong Zhang^*

Oncology Research, Vol.26, No.6, pp. 933-940, 2018, DOI:10.3727/096504017X15144741233346

Abstract Osteosarcoma is one of the most aggressive malignancies with poor prognosis rates. Many studies have demonstrated that miRNAs were involved in osteosarcoma, but the role of miR-103a in osteosarcoma remains elusive. In this study, we detected the expression levels of miR-103 in osteosarcoma and non-osteosarcoma tissues and cell lines. The binding effect of miR-103 on p57 was detected by luciferase reporter assay. After altering expressions of miR-103 or p57, viability, migration, invasion, and apoptosis of MG63 cells and expressions of proteins related with the JNK/STAT and mTOR pathways were all detected. We found the higher More >

Xingzi Yang¹, Wei Gao², Xiaodu Wang¹, Xiaowei Zeng^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.2, pp. 1299-1313, 2024, DOI:10.32604/cmes.2024.049371

Abstract The bioinspired nacre or bone structure represents a remarkable example of tough, strong, lightweight, and multifunctional structures in biological materials that can be an inspiration to design bioinspired high-performance materials. The bioinspired structure consists of hard grains and soft material interfaces. While the material interface has a very low volume percentage, its property has the ability to determine the bulk material response. Machine learning technology nowadays is widely used in material science. A machine learning model was utilized to predict the material response based on the material interface properties in a bioinspired nanocomposite. This model More >

Chirag Ganguli¹, Shishir Kumar Shandilya², Michal Gregus³, Oleh Basystiuk^4,*

Computer Systems Science and Engineering, Vol.48, No.3, pp. 739-758, 2024, DOI:10.32604/csse.2024.042607

Abstract Cyber Defense is becoming a major issue for every organization to keep business continuity intact. The presented paper explores the effectiveness of a meta-heuristic optimization algorithm-Artificial Bees Colony Algorithm (ABC) as an Nature Inspired Cyber Security mechanism to achieve adaptive defense. It experiments on the Denial-Of-Service attack scenarios which involves limiting the traffic flow for each node. Businesses today have adapted their service distribution models to include the use of the Internet, allowing them to effectively manage and interact with their customer data. This shift has created an increased reliance on online services to store… More >

Nguyen Huu Loc Khuu^1,2,3, Thuy Duy Truong^1,2,3, Quoc Dien Le^1,2,3, Tran Thanh Cong Vu^1,2,3, Hoa Binh Tran^1,2,3, Tuong Quan Vo^1,2,3,*

Intelligent Automation & Soft Computing, Vol.39, No.2, pp. 255-279, 2024, DOI:10.32604/iasc.2024.043854

Abstract Optimizing Flow Path Design (FPD) is a popular research area in transportation system design, but its application to Overhead Transportation Systems (OTSs) has been limited. This study focuses on optimizing a double-spine flow path design for OTSs with 10 stations by minimizing the total travel distance for both loaded and empty flows. We employ transportation methods, specifically the North-West Corner and Stepping-Stone methods, to determine empty vehicle travel flows. Additionally, the Tabu Search (TS) algorithm is applied to branch the 10 stations into two main layout branches. The results obtained from our proposed method demonstrate More >