HEYI LIU^1,#, WENHAO CHENG^2,#, JINGLIANG HE², LUYAO ZHANG², KADIRYA ASAN², YULU CHEN², JIAYUN WANG², QI GAO², SENG WANG², ZIEN YU², SHAOJIE MA², LAN ZHU^3,*, JING JI^2,3,*

BIOCELL, Vol.48, No.10, pp. 1465-1473, 2024, DOI:10.32604/biocell.2024.052670 - 02 October 2024

Abstract Background: Osteosarcoma is the most common primary bone malignancy, with a strong tendency towards local invasion and metastasis. The SRY-Box Transcription Factor 1 (SOX1) gene, a member of the HMG-box family of DNA-binding transcription factors, plays a crucial role in embryogenesis and tumorigenesis. However, its role in osteosarcoma, particularly in relation to metastatic potential, is not well understood. Methods: The GSE14359 dataset containing five samples of conventional osteosarcoma and four samples of lung metastatic osteosarcoma was obtained from the Gene Expression Omnibus (GEO) database and analyzed for differential gene expression using the R language. Gene… More >

ISIDORA PETROVIC¹, MILENA MILIVOJEVIC¹, ANA ARSENIJEVIC², ANDRIJANA LAZIC¹, NATASA KOVACEVIC GRUJICIC¹, MARIJA SCHWIRTLICH¹, JELENA POPOVIC³, MILENA STEVANOVIC^1,4,5,*

BIOCELL, Vol.45, No.5, pp. 1355-1367, 2021, DOI:10.32604/biocell.2021.015817 - 12 July 2021

Abstract Genetic and molecular heterogeneity, together with intrinsic and acquired resistance to therapy, represent the major obstacles to the successful treatment of different types of breast carcinoma. Increasing evidence demonstrates that SOX transcription factors in breast carcinomas could act both as oncogenes and tumor suppressors and have been associated with tumor stage and grade, poor prognosis, and therapy resistance. Both SOX2 and SOX18 overexpression has been correlated with poor prognosis in breast carcinomas, and these genes are recognized as potential antitumor targets. Our aim was to evaluate the effect of retinoic acid (RA), a well-known cyto-differentiating agent,… More >

HAIFENG WANG^1,2, KAI WANG¹, JUAN GUO¹, TIEQIAO WEN²

BIOCELL, Vol.43, No.2, pp. 59-64, 2019, DOI:10.32604/biocell.2019.05731

Abstract Histone deacetylation is a key modulator involved in cell proliferation, apoptosis, and mRNA transcription. However, the effects of histone deacetylation on C17.2 neural stem cells (NSCs) remain unclear. Here, the histone deacetylase inhibitors nicotinamide and trichostatin A (TSA) were used to determine the role of histone deacetylation on gene transcription in NSCs. The results showed that the mRNA expression of p53, Sox1, Sox2, and Bax were significantly higher in E14.5 NSCs than in C17.2 NSCs. Nestin, a marker gene of neuronal differentiation, did not differ significantly between E14.5 NSCs and C17.2 NSCs. The transcription levels More >