Yang Deng^1,#, Tong Su^1,#, Bin Wu¹, Li Peng², Muyu Chen^1,2,*, Liang Zhang^1,*

International Journal of Mental Health Promotion, Vol.28, No.1, 2026, DOI:10.32604/ijmhp.2025.072327 - 28 January 2026

Abstract Background: Submarine personnel often experience insomnia and reduced psychological resilience due to extended deployments in confined, high-stress environments. Effective non-pharmacological interventions are needed to improve sleep quality and resilience in this population. This study aimed to investigate the effect of virtual reality (VR) combined with forest therapy interventions on psychological resilience and sleep quality among submarine personnel with insomnia symptoms. Methods: Using convenience sampling, 92 submarine personnel with insomnia symptoms undergoing recuperation at a PLA sanatorium between July 2023 and May 2025 were randomly allocated to experimental and control groups (n = 46 each). The control group… More >

Marwa M. Eid^1,2,*, Amel Ali Alhussan³, Ebrahim A. Mattar⁴, Nima Khodadadi^5,*, El-Sayed M. El-Kenawy^6,7

CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.1, 2026, DOI:10.32604/cmes.2025.073555 - 29 January 2026

Abstract Accurate prediction of concrete compressive strength is fundamental for optimizing mix designs, improving material utilization, and ensuring structural safety in modern construction. Traditional empirical methods often fail to capture the non-linear relationships among concrete constituents, especially with the growing use of supplementary cementitious materials and recycled aggregates. This study presents an integrated machine learning framework for concrete strength prediction, combining advanced regression models—namely CatBoost—with metaheuristic optimization algorithms, with a particular focus on the Somersaulting Spider Optimizer (SSO). A comprehensive dataset encompassing diverse mix proportions and material types was used to evaluate baseline machine learning models,… More >

Sandra Kałużna^1,*, Monika Świerczewska^1,2, Sylwia Ciesiółka¹, Małgorzata Partyka¹, Michał Nowicki¹, Karolina Wojtowicz¹

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070356 - 30 December 2025

Abstract The last research focuses on the role of exosomes in cancer treatment. Exosomes are extracellular vesicles. They can be secreted by cancer cells, and they can modulate chemotherapy sensitivity. Determining exosomal content opens the possibility for guiding treatment strategies for cancer diseases. Exosomal microRNA are considered one of the prime candidates for exosomal biomarkers. Exosomal circular RNAs represent excellent biomarkers for liquid biopsy because of their stability in many types of cancer. Exosomal proteins remain reliable biomarkers also. Exosomes have emerged as promising therapeutic candidates. Their biological properties render them ideal vectors for drug delivery.… More >

Xiangmei Ye^1,2,3, Baoyi Yang⁴, Xin Zhang⁵, Luyuan Yang¹, Likun Zhang⁵, Qin Ren¹, Xiaobing Li¹, Leiguang Feng¹, Lanlan Wei^3,6,7,*, Peng Song¹, Yuqing Ye⁸, Xin Lian⁹, Yujuan Gao⁹, Haidi Tang¹, Zhiyu Liu¹

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.068814 - 30 December 2025

Abstract Objectives: Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia and Philadelphia-like B-cell acute lymphoblastic leukemia (Ph+/Ph-like ALL) constitute the majority of relapsed/refractory B-ALL (R/R B-ALL) cases, highlighting an urgent need to discover new therapeutic targets. This study aims to elucidate the mechanisms underlying poor prognosis in Ph+/Ph-like ALL through transcriptome sequencing and functional cytological assays, with the goal of informing new clinical treatment strategies. Results: Transcriptomic analysis of Ph+/Ph-like ALL patients revealed that low expression of P2X Purinoceptor 1 (P2RX1) was associated with unfavorable outcomes. Specifically, patients with poor prognosis and low P2RX1 expression exhibited downregulation of… More >

Xiaopan Zou^1,2, Meiyang Sun³, Xin Jiang¹, Jingze Yu², Xiaomeng Li^4,*, Bingyu Nie^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.066662 - 30 December 2025

Abstract Objective: Triple-negative breast cancer (TNBC) is highly aggressive and lacks an effective targeted therapy. This study aimed to elucidate the functions and possible mechanisms of action of zinc finger miz-type containing 2 (ZMIZ2) and minichromosome maintenance complex component 3 (MCM3) in TNBC progression. Methods: The relationship between ZMIZ2 expression and clinical characteristics of TNBC was investigated. In vitro and in vivo experiments were performed to investigate the role of ZMIZ2 dysregulation in TNBC cell malignant behaviors. The regulatory relationship between ZMIZ2 and MCM3 was also explored. Transcriptome sequencing was performed to elucidate possible mechanisms underlying the ZMIZ2/MCM3… More >

Jay Barach^*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-23, 2026, DOI:10.32604/cmc.2025.071705 - 09 December 2025

Abstract Human Resource (HR) operations increasingly rely on cloud-based platforms that provide hiring, payroll, employee management, and compliance services. These systems, typically built on multi-tenant microservice architectures, offer scalability and efficiency but also expand the attack surface for adversaries. Ransomware has emerged as a leading threat in this domain, capable of halting workflows and exposing sensitive employee records. Traditional defenses such as static hardening and signature-based detection often fail to address the dynamic requirements of HR Software as a Service (SaaS), where continuous availability and privacy compliance are critical. This paper presents a Moving Target Defense… More >

Zheng Yao^*, Puqing Chang

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-18, 2026, DOI:10.32604/cmc.2025.068248 - 10 November 2025

Abstract As Internet of Things (IoT) applications expand, Mobile Edge Computing (MEC) has emerged as a promising architecture to overcome the real-time processing limitations of mobile devices. Edge-side computation offloading plays a pivotal role in MEC performance but remains challenging due to complex task topologies, conflicting objectives, and limited resources. This paper addresses high-dimensional multi-objective offloading for serial heterogeneous tasks in MEC. We jointly consider task heterogeneity, high-dimensional objectives, and flexible resource scheduling, modeling the problem as a Many-objective optimization. To solve it, we propose a flexible framework integrating an improved cooperative co-evolutionary algorithm based on More >

Sapan Pandya^*

Journal of Cyber Security, Vol.7, pp. 637-651, 2025, DOI:10.32604/jcs.2025.073670 - 24 December 2025

Abstract Ransomware has evolved from opportunistic malware into a global economic weapon, crippling critical services and extracting billions in illicit revenue. While most research has centered on enterprise networks and healthcare systems, an equally vulnerable frontier is emerging in lottery and betting kiosks—self-service financial Internet of Things (IoT) devices that handle billions of dollars annually. These terminals operate unattended, rely on legacy operating systems, and interact with sensitive transactional data, making them prime ransomware targets. This paper introduces a Resilient Security Framework (RSF) for kiosks under ransomware threat conditions. RSF integrates three defensive layers: (1) prevention… More >

Yan Gui^1,#, Wen Pan^1,#, Ziyi Dong^1,#, Dongzhi Hu^1,#, Yaoyang Guo¹, Xinyi Wen¹, Haiyang Zhang², Zhansheng Jiang^1,*, Xiangqian Zheng^1,*, Ming Gao^2,*, Junyi Wang^1,*

Oncology Research, Vol.33, No.12, pp. 3991-4011, 2025, DOI:10.32604/or.2025.067182 - 27 November 2025

Abstract Objectives: Metastatic spread to the lung is one of the leading causes of fatal outcomes in thyroid cancer, but the underlying molecular mechanisms remain unclear. To investigate how exosomal microRNA-17-5p (miR-17-5p) promotes lung metastasis in thyroid cancer within the framework of the “seed and soil” hypothesis. Methods: Serum exosomes from thyroid cancer lung metastasis patients and controls were analyzed for miR-17, which was elevated in metastatic cases. miR-17 was transfected into embryonic lung fibroblasts (MRC-5), and their supernatants were co-cultured with thyroid cancer cells (Cal62). Cell proliferation and migration were evaluated using colony formation, Ki67… More >

Miljenko Lapaine^*

Revue Internationale de Géomatique, Vol.34, pp. 793-808, 2025, DOI:10.32604/rig.2025.066916 - 06 November 2025

Abstract The paper investigates the properties of the Lambert equivalent azimuthal projection, which is often used in normal aspect in atlases for maps of the northern and southern hemispheres. The field of research is theoretical in nature and assumes a mastery of mathematics because it deals with map projections. The transverse aspect is commonly used for eastern and western hemisphere atlas maps. In addition, the Hammer projection was created from the transverse aspect of that projection. Therefore, if we want to get to know the Hammer projection better, we must first investigate the Lambert equivalent azimuthal… More >