YaJie Cui*†, Kai’e She‡, Defu Tian§, Peilian Zhang†, Xiaoyan Xin*
Oncology Research, Vol.23, No.6, pp. 275-282, 2015, DOI:10.3727/096504016X14562725373798
Abstract Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, accounting for 90% of all
ovarian cancer. Dysregulation of miRNAs is associated with several types of EOC. In the current research,
we aimed to study the role of abnormal expression of miR-146a in the development of EOC and to elucidate
the possible molecular mechanisms. Compared with control samples, mRNA expression of miR-146a was
significantly decreased in EOC tissues and cell lines. Overexpression of miR-146a prohibited cell proliferation, enhanced apoptosis, and increased sensitivity to chemotherapy drugs in EOC cells. In contrast,
downregulation of miR-146a promoted cell… More >
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