Mahsa Keshavarz-Fathi1,2,3, Golshid Sanati3,4,5, Maryam Sadr3, Bahareh Mohebbi3, Vahid Ziaee6,7, Nima Rezaei3,5,8
European Cytokine Network, Vol.32, No.3, pp. 48-54, 2021, DOI:10.1684/ecn.2021.0469
Abstract Cytokine dysregulation is one of the important hallmarks of systemic lupus erythematosus (SLE) in both
pediatric and adult patients. Owing to the substantial role of Janus kinase (JAK) and suppressor of cytokine signaling
(SOCS) in cytokine signaling, we compared the methylation status of the promoter of JAK2 and SOCS3 between
patients with JSLE and healthy controls. Methods: Peripheral blood samples were obtained from patients with JSLE
and healthy controls. The promoter methylation was assessed by using the bisulfite conversion system and real-time
quantitative multiplex methylation-specific PCR (QM-MSP). Results: The methylation assessments were performed
on the… More >
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