CHUAN JIANG^1,2, CHUNLEI LIU^1,3, XI YAO^1,3, JINGYA SU^1,2, WEI LU^1,3, ZHENGBO WEI^3,*, YING XIE^1,2,*

Oncology Research, Vol.32, No.12, pp. 1935-1948, 2024, DOI:10.32604/or.2024.052244 - 13 November 2024

Abstract Background: Head and neck squamous cell carcinoma (HNSCC) is a prevalent form of cancer globally, with chemoresistance posing a major challenge in treatment outcomes. The efficacy of the commonly used chemotherapeutic agent, cisplatin, is diminished in patients with poor prognoses. Methods: Various bioinformatics databases were utilized to examine Carboxylesterase 1 (CES1) gene expression, clinicopathologic features, patient survival analysis, and gene function. An organoid model of HNSCC was established, along with the induction of drug-resistant HNSCC in the organoid model. CES1 expression was assessed using qRT-PCR and Western Blot, and differential markers were identified through transcriptome… More >

YOUSEF KATIB^1,*, NASSER MULLA²

Oncology Research, Vol.32, No.11, pp. 1803-1809, 2024, DOI:10.32604/or.2024.052358 - 16 October 2024

Abstract Background: Lung cancer (LC) is one of the most common neoplastic diseases and a leading cause of death in Saudi Arabia. Its incidence in Saudi Arabia has increased by more than 3% within two decades. Our study aimed to describe the epidemiological and genetic landscapes of LC in Al-Madinah city in Saudi Arabia. Methods: A retrospective analysis was conducted on the medical records of 65 patients diagnosed with lung cancer between 2015 and 2021 at a single medical oncology center in Al-Madinah city of Saudi Arabia. Results: The mean patients’ age was 59.2 years, with 50… More >

Biao Wang¹, Yuxiang Peng^1,*, Wenhua Xu²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.3, pp. 1-2, 2024, DOI:10.32604/icces.2024.012061

Abstract The damage process of ship structures under near-field underwater explosions involves strong nonlinear coupling effects of multiple media, and its numerical simulation poses a serious challenge to traditional numerical algorithms. Based on previous research, this article first establishes a highly compressible multiphase flow numerical calculation model based on the high-precision Discontinuous Galerkin Method (DGM) and a ship elastic-plastic damage dynamic model based on the meshless Reproducing Kernel Particle Method (RKPM). Furthermore, we develop an algorithm for grid-independent dynamic expansion of cracks. Based on this, the Boundary Data Immersion Method (BDIM) is used to couple the More >

Ji-Su Park¹, Tae-Hyeon Lee², Il-Su Park^3,*

International Journal of Mental Health Promotion, Vol.26, No.9, pp. 745-755, 2024, DOI:10.32604/ijmhp.2024.054630 - 20 September 2024

Abstract Background: In response to the need for research clearly demonstrating the net effect of smoking cessation on mental health status, considering the causal relationship between smoking cessation and changes in mental health status, this study was undertaken. Thus, this study aimed to examine the net effect of short-term smoking cessation on five specific mental health metrics and the overall mental health status score. Methods: We used data from the first wave of the Korean Health Panel (KHP) Survey (2011–2013, 2016–2018) and focused on men aged 19 years and older, to explore the effects of smoking… More >

P. K. A. Chitra¹, S. Appavu alias Balamurugan², S. Geetha³, Seifedine Kadry^4,5,6, Jungeun Kim^7,*, Keejun Han⁸

Computer Systems Science and Engineering, Vol.48, No.5, pp. 1367-1385, 2024, DOI:10.32604/csse.2023.034373 - 13 September 2024

Abstract A generalization of supervised single-label learning based on the assumption that each sample in a dataset may belong to more than one class simultaneously is called multi-label learning. The main objective of this work is to create a novel framework for learning and classifying imbalanced multi-label data. This work proposes a framework of two phases. The imbalanced distribution of the multi-label dataset is addressed through the proposed Borderline MLSMOTE resampling method in phase 1. Later, an adaptive weighted l₂₁ norm regularized (Elastic-net) multi-label logistic regression is used to predict unseen samples in phase 2. The proposed… More >

Zhisheng Xu¹, Juan Wang¹, Zihan Yu¹, Jiaming Zhao^2,*

Frontiers in Heat and Mass Transfer, Vol.22, No.4, pp. 1129-1151, 2024, DOI:10.32604/fhmt.2024.053695 - 30 August 2024

Abstract Called island-crossing tunnels, some specific underwater tunneling projects face constraints imposed by geological and water conditions, necessitating their passage through artificial or natural islands. The longitudinal of the tunnel follows a W-shaped distribution. The congestion situation does not allow for immediate longitudinal smoke exhaust at the early stage of the fire, and the natural spread of smoke is complicated. An exhaustive investigation was carried out to analyze the smoke behaviors during a fire incident, employing the fire dynamics software FDS, considering five slopes and four fire locations. The simulation results reveal that the layer of… More >

Liang Yi, Zhiqiang Lei, Zhisheng Xu, Yaolong Yin, Houlin Ying^*

Frontiers in Heat and Mass Transfer, Vol.22, No.4, pp. 977-996, 2024, DOI:10.32604/fhmt.2024.053688 - 30 August 2024

Abstract This paper explores the smoke flow characteristics in tunnel fires, giving a particular emphasis on the effects of different distances between the smoke outlets and the fire source. It examines the smoke behavior under different conditions, including variations in heat release rates, exhaust volumetric flow rates, spacing between smoke outlets, and the longitudinal fire source positions. Results indicate that altering the fire source positions and the smoke outlets in the tunnel leads to variations in the properties of smoke flow both the fire source upstream and downstream; the distance between fire source and smoke outlet… More > Graphic Abstract

Ruobing Zuo¹, Xiaohan Huang¹, Xuguo Jiao^2,3, Zhenyong Zhang^1,4,5,*

CMC-Computers, Materials & Continua, Vol.80, No.2, pp. 3333-3349, 2024, DOI:10.32604/cmc.2024.050544 - 15 August 2024

Abstract In the rapidly evolving urban landscape, outdoor parking lots have become an indispensable part of the city’s transportation system. The growth of parking lots has raised the likelihood of spontaneous vehicle combustion, a significant safety hazard, making smoke detection an essential preventative step. However, the complex environment of outdoor parking lots presents additional challenges for smoke detection, which necessitates the development of more advanced and reliable smoke detection technologies. This paper addresses this concern and presents a novel smoke detection technique designed for the demanding environment of outdoor parking lots. First, we develop a novel… More >

Elham A. Badr¹, Gehan Sh. Bakhoum¹, Mervat Sh. Sadak², Ibrahim Al-Ashkar³, Mohammad Sohidul Islam⁴, Ayman El Sabagh^5,6,*, Magdi T. Abdelhamid^2,7,*

Phyton-International Journal of Experimental Botany, Vol.93, No.7, pp. 1623-1645, 2024, DOI:10.32604/phyton.2024.054453 - 30 July 2024

Abstract While Egypt’s canola production per unit area has recently grown, productivity remains low, necessitating increased productivity. Hydrogels are water-absorbent polymer compounds that can optimize irrigation schedules by increasing the soil’s ability to retain water. Accordingly, two field experiments were conducted to examine hydrogel application to sandy soil on canola growth, biochemical aspects, yield, yield traits, and nutritional quality of yielded seeds grown under water deficit stress conditions. The experiments were conducted by arranging a split-plot layout in a randomized complete block design (RCBD) with three times replications of each treatment. While water stress at 75%… More >

Zhisheng Xu^*, Sohail Mahmood, Zihan Yu

Frontiers in Heat and Mass Transfer, Vol.22, No.3, pp. 791-816, 2024, DOI:10.32604/fhmt.2024.051058 - 11 July 2024

Abstract The centralized smoke exhaust system of shield tunnel is an important determinant for tunnel fire safety, and the use of different design parameters of the tunnel smoke exhaust system will affect the smoke exhaust effect in the tunnel, and the influence of different design parameters on the smoke exhaust effect and temperature attenuation of the tunnel can help engineers in designing a more effective centralized smoke exhaust system for the tunnel. In this paper, the Fire Dynamic Simulator (FDS) is utilized to examine smoke exhaust vent settings for a centralized exhaust system in shield tunnel… More >