Qun Zhang, Ruixia Su, Chun Shan, Chao Gao, Pei Wu

Oncology Research, Vol.26, No.2, pp. 269-276, 2018, DOI:10.3727/096504017X15075967560980

Abstract Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Currently, only chemoembolization and sorafenib have shown survival benefits for advanced HCC. There are major unmet needs in HCC management and the discovery of new therapeutic targets. Here we identified NCAPG (non-SMC condensin I complex, subunit G) as a novel mitotic gene required for HCC cell proliferation and migration through siRNA knockdown of a panel of novel overexpressed genes in HCC based on The Cancer Genome Atlas (TCGA) dataset. We found that knockdown of NCAPG induces HCC cell mitosis and inhibits cell growth, More >

WEILAN LIU, XIAOYAN DUAN, KAIYUN QIN, YAN JIANG, CAIFU ZHAO, CONGWEI DAI^*

BIOCELL, Vol.47, No.11, pp. 2471-2484, 2023, DOI:10.32604/biocell.2023.029617

Abstract Introduction: Structural maintenance of chromosome 1A (SMC1A) is a crucial compound of the cohesin complex. It has been reported to regulate the epithelial-mesenchymal transition (EMT) process in multiple cancers. Objectives: The present study aims to further clarify the role of SMC1A in cervical cancer. Methods: We analyzed data from four datasets and confirmed that SMC1A showed high expression in cervical cancer samples and was related to poor prognosis of patients with cervical cancer. Cell proliferation of SiHa and C-33A with knockdown of SMC1A was assessed using CCK-8 and colony formation assay. The migration and invasion were… More > Graphic Abstract

R.V. Reji, S. Anil Lal^†

Frontiers in Heat and Mass Transfer, Vol.7, pp. 1-8, 2016, DOI:10.5098/hmt.7.27

Abstract DSMC simulation of re-entry of an object with shape and size close to that of ISRO’s Space Recovery Experiment (SRE) capsule has been analysed using the open-source tool dsmcFoam for three altitude conditions, viz. 85 km, 100 km and 115 km, and for three angles of attack, viz. 0 o , 20o&40o . The hypersonic free stream velocity of 8000 m/s and boundary surface temperature of 300 K have been used for the simulations. The variation of parameters such as surface heat flux, surface pressure, shear stress, slip velocity, temperature jump and integrals such as More >

Xiangfei Li, Yang Yin, Yang Zhou, Wenchang Liu, Kaihui Zhao^*

Energy Engineering, Vol.120, No.2, pp. 277-297, 2023, DOI:10.32604/ee.2023.022461

Abstract This paper presents a novel non-singular fast terminal sliding mode control (NFTSMC) based on the deep flux weakening switching point tracking method in order to improve the control performance of permanent interior magnet synchronous motor (IPMSM) drive systems. The mathematical model of flux weakening (FW) control is established, and the deep flux weakening switching point is calculated accurately by analyzing the relationship between the torque curve and voltage decline curve. Next, a second-order NFTSMC is designed for the speed loop controller to ensure that the system converges to the equilibrium state in finite time. Then, More > Graphic Abstract

Ahmed M. Elmogy^1,2,*, Wael M. Elawady²

Intelligent Automation & Soft Computing, Vol.36, No.1, pp. 385-400, 2023, DOI:10.32604/iasc.2023.032349

Abstract One of the great concerns when tackling nonlinear systems is how to design a robust controller that is able to deal with uncertainty. Many researchers have been working on developing such type of controllers. One of the most efficient techniques employed to develop such controllers is sliding mode control (SMC). However, the low order SMC suffers from chattering problem which harm the actuators of the control system and thus unsuitable to be used in many practical applications. In this paper, the drawbacks of low order traditional sliding mode control (FOTSMC) are resolved by presenting a… More >

A. Jegatheesh^1,*, M. Germin Nisha², N. Kopperundevi³

Intelligent Automation & Soft Computing, Vol.36, No.1, pp. 745-760, 2023, DOI:10.32604/iasc.2023.028011

Abstract Interacting The highest storage capacity of a circular tank makes it popular in process industries. Because of the varying surface area of the cross-sections of the tank, this two-tank level system has nonlinear characteristics. Controlling the flow rate of liquid is one of the most difficult challenges in the production process. This proposed effort is critical in preventing time delays and errors by managing the fluid level. Several scholars have explored and explored ways to reduce the problem of nonlinearity, but their techniques have not yielded better results. Different types of controllers with various techniques… More >

Nikhil Gadewal^*1, Rohit Kumar^†1, Swapnil Aher^†, Anagha Gardane^†, Tarang Gaur^†, Ashok K. Varma^*‡§, Navin Khattry^¶, Syed K. Hasan^†§¶

Oncology Research, Vol.28, No.3, pp. 321-330, 2020, DOI:10.3727/096504020X15816752427321

Abstract Acute myeloid leukemia (AML) with NPM1 mutation is a disease driving genetic alteration with good prognosis. Although it has been suggested that NPM1 mutation induces chemosensitivity in leukemic cells, the underlying cause for the better survival of NPM1 mutated patients is still not clear. Mutant NPM1 AML has a unique microRNA and their target gene (mRNA) signature compared to wild-type NPM1. Dynamic regulation of miRNA–mRNA has been reported to influence the prognostic outcome. In the present study, in silico expression data of miRNA and mRNA in AML patients was retrieved from genome data commons, and differentially expressed miRNA… More >

Ahmed M. Elmogy^1,2,*, Amany Sarhan², Wael M. Elawady²

CMC-Computers, Materials & Continua, Vol.72, No.3, pp. 5629-5641, 2022, DOI:10.32604/cmc.2022.025247

Abstract As most real world systems are significantly nonlinear in nature, developing robust controllers have attracted many researchers for decades. Robust controllers are the controllers that are able to cope with the inherent uncertainties of the nonlinear systems. Many control methods have been developed for this purpose. Sliding mode control (SMC) is one of the most commonly used methods in developing robust controllers. This paper presents a higher order SMC (HOSMC) approach to mitigate the chattering problem of the traditional SMC techniques. The developed approach combines a third order SMC with an adaptive PID (proportional, integral, More >

Kaihui Zhao^1,2, Wenchang Liu¹, Tonghuan Yin³, Ruirui Zhou⁴, Wangke Dai¹ and Gang Huang^5,*

Energy Engineering, Vol.119, No.2, pp. 767-780, 2022, DOI:10.32604/EE.2021.018617

Abstract This paper presents a novel model-free sliding mode control (MFSMC) method to improve the speed response of permanent magnet synchronous machine (PMSM) drive system. The ultra-local model (ULM) is first derived based on the input and the output of the PMSM. Then, the novel MFSMC method is presented, and the controller is designed based on ULM and MFSMC. A sliding mode observer (SMO) is constructed to estimate the unknown part of the ULM. The estimated unknown part is feedbacked to MFSMC controller to perform compensation for parameter perturbations and external disturbances. Compared with the sliding More >

TING LAN, SHENG QIN, XIAOJIN GONG, PING ZHENG, JIAXIN YAN, YANG LIU^*

BIOCELL, Vol.45, No.5, pp. 1313-1319, 2021, DOI:10.32604/biocell.2021.015923

Abstract Invasive stratified mucin-producing carcinoma (ISMC) is a recently described histologic variant of high-risk human papillomavirus (HPV)-associated endocervical adenocarcinoma, as the putative invasive counterpart of the stratified mucin-producing intraepithelial lesion (SMILE). ISMC can display variable architectural patterns and usually coexists with other more conventional types of HPV-associated carcinomas, which makes diagnosis and differential diagnosis of ISMC is difficult for pathologists. Moreover, the prognosis of ISMC is still controversial. We analyzed 6 ISMCs with detailed pathological and clinical information. Intraepithelial lesion, including 1 high-grade squamous intraepithelial lesion and 1 SMILE, was found. Various architectures were observed (including… More >