Qian Li, Jing Jin, Jianghui Liu, Liqun Wang, Yutong He
Oncology Research, Vol.24, No.3, pp. 205-214, 2016, DOI:10.3727/096504016X14648701447896
Abstract We recently found that SLC39A5 (ZIP5), a zinc transporter, is overexpressed in esophageal cancer. Downregulation of ZIP5 inhibited the proliferation, migration, and invasion of the esophageal cancer cell line
KYSE170 in vitro. In this study, we found that downregulation of SLC39A5 (ZIP5) by interference resulted
in a significant reduction in esophageal cancer tumor volume and weight in vivo. COX2 (cyclooxygenase 2)
expression was decreased and E-cadherin expression was increased in the KYSE170K xenografts, which was
caused by the downregulation of ZIP5. However, we did not find that the downregulation of ZIP5 caused a
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