Antonello Di Paolo1, Paola Orlandi1, Teresa Di Desidero, Romano Danesi, Guido Bocci
Oncology Research, Vol.25, No.7, pp. 1129-1140, 2017, DOI:10.3727/096504017X14841698396900
Abstract The combination of folinate salts to 5-fluoruracil (5-FU)-based schedules is an established clinical routine in
the landscape of colorectal cancer treatment. The aim of this study was to investigate the pharmacological differences between the sequential administration of folinate salts (1 h before, as in clinical routine) followed by
5-FU and the simultaneous administration of both drugs. Proliferation and apoptotic assays were performed on
human colon cancer cells exposed to 5-FU, calcium (CaLV), or disodium (NaLV) levofolinate or their simultaneous and sequential combination for 24 and 72 h. TYMS and SLC19A1 gene expression was performed
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