Zhi Li¹, Yufei Zhao², Yueming Ji², Hanwen Gu², Zaibin Jiao^2,*

Energy Engineering, Vol.121, No.12, pp. 3899-3927, 2024, DOI:10.32604/ee.2024.055899 - 22 November 2024

Abstract By integrating advanced digital technologies such as cloud computing and the Internet of Things in sensor measurement, information communication, and other fields, the digital DC distribution network can efficiently and reliably access Distributed Generator (DG) and Energy Storage Systems (ESS), exhibiting significant advantages in terms of controllability and meeting requirements of Plug-and-Play (PnP) operations. However, during device plug-in and -out processes, improper system parameters may lead to small-signal stability issues. Therefore, before executing PnP operations, conducting stability analysis and adjusting parameters swiftly is crucial. This study introduces a four-stage strategy for parameter optimization to enhance… More >

Mosab Manaseer¹, Maram Bani Younes^2,*

Computer Systems Science and Engineering, Vol.48, No.6, pp. 1699-1721, 2024, DOI:10.32604/csse.2024.055128 - 22 November 2024

Abstract This work aims to examine the vulnerabilities and threats in the applications of intelligent transport systems, especially collision avoidance protocols. It focuses on achieving the availability of network communication among traveling vehicles. Finally, it aims to find a secure solution to prevent blackhole attacks on vehicular network communications. The proposed solution relies on authenticating vehicles by joining a blockchain network. This technology provides identification information and receives cryptography keys. Moreover, the ad hoc on-demand distance vector (AODV) protocol is used for route discovery and ensuring reliable node communication. The system activates an adaptive mode for monitoring More >

Mohana Priya Govindarajan^*, Sangeetha Subramaniam Karuppaiya Bharathi

CMC-Computers, Materials & Continua, Vol.81, No.2, pp. 2967-2986, 2024, DOI:10.32604/cmc.2024.055536 - 18 November 2024

Abstract In the present research, we describe a computer-aided detection (CAD) method aimed at automatic fetal head circumference (HC) measurement in 2D ultrasonography pictures during all trimesters of pregnancy. The HC might be utilized toward determining gestational age and tracking fetal development. This automated approach is particularly valuable in low-resource settings where access to trained sonographers is limited. The CAD system is divided into two steps: to begin, Haar-like characteristics were extracted from ultrasound pictures in order to train a classifier using random forests to find the fetal skull. We identified the HC using dynamic programming,… More >

YUQIN YIN^1,2,#, YU WU^1,#, HONGLIANG HUANG^1,2, YINGYING DUAN^1,2, ZHONGWEN YUAN^1,2, LIHUI CAO^1,2, JINJIN YING^1,2, YONGHENG ZHOU^3,*, SENLING FENG^1,2,*

Oncology Research, Vol.32, No.12, pp. 1891-1902, 2024, DOI:10.32604/or.2024.048778 - 13 November 2024

Abstract Background: Polymethoxylated flavones (PMFs) are compounds present in citrus peels and other Rutaceae plants, which exhibit diverse biological activities, including robust antitumor and antioxidant effects. However, the mechanism of PMFs in reversing drug resistance to colon cancer remains unknown. In the present study, we aimed to investigate the potential connection between the aerobic glycolysis-ROS-autophagy signaling axis and the reversal of PTX resistance in colon cancer by PMFs. Methods: MTT Cell viability assay and colony formation assay were used to investigate the effect of PMFs combined with PTX in reversing HCT8/T cell resistance ex vivo; the mRNA… More > Graphic Abstract

YUAN YIN¹, ZHENGYIN WANG¹, YUJIE HU¹, JIA WANG¹, YI WANG^2,*, QUN LU^1,*

Oncology Research, Vol.32, No.12, pp. 1881-1890, 2024, DOI:10.32604/or.2024.048007 - 13 November 2024

Abstract Background: Caffeic acid (CA) is considered a promising phytochemical that has inhibited numerous cancer cell proliferation. Therefore, it is gaining increasing attention due to its safe and pharmacological applications. In this study, we investigated the role of CA in inhibiting the Interleukin-6 (IL-6)/Janus kinase (JAK)/Signal transducer and activator of transcription-3 (STAT-3) mediated suppression of the proliferation signaling in human prostate cancer cells. Materials and Methods: The role of CA in proliferation and colony formation abilities was studied using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay and colony formation assays. Tumour cell death and cell cycle arrest were… More >

YUSHI YANG^1,#, CHUJIAO HU^2,#, SHAN LEI³, XIN BAO³, ZHIRUI ZENG^3,*, WENPENG CAO^4,*

Oncology Research, Vol.32, No.12, pp. 1921-1934, 2024, DOI:10.32604/or.2024.046191 - 13 November 2024

Abstract Background: The heterogeneity of prognosis and treatment benefits among patients with gliomas is due to tumor microenvironment characteristics. However, biomarkers that reflect microenvironmental characteristics and predict the prognosis of gliomas are limited. Therefore, we aimed to develop a model that can effectively predict prognosis, differentiate microenvironment signatures, and optimize drug selection for patients with glioma. Materials and Methods: The CIBERSORT algorithm, bulk sequencing analysis, and single-cell RNA (scRNA) analysis were employed to identify significant cross-talk genes between M2 macrophages and cancer cells in glioma tissues. A predictive model was constructed based on cross-talk gene expression, and… More >

Priyanka¹, Damodarakurup Sajeev², Shaik Ahmed³, Shankar Pidishety³, Ram Soorat^3,*

Journal of Quantum Computing, Vol.6, pp. 53-66, 2024, DOI:10.32604/jqc.2024.054000 - 14 November 2024

Abstract The present study delves into the application of investigating quantum state behaviour, particularly focusing on coherent and superposition states. These states, characterized by their remarkable stability and precision, have found extensive utility in various domains of quantum mechanics and quantum information processing. Coherent states are valuable for manipulating quantum systems with accuracy. Superposition states allow quantum systems to exist in numerous configurations at the same time, which paves the way for quantum computing’s capacity for parallel processing. The research accentuates the crucial role of quantum error correction (QEC) in ensuring the stability and reliability of… More >

A. NOEL GRAVINA^1,2, NOELIA D´ELÍA^1,2, LUCIANO A. BENEDINI^2,3,*, PAULA MESSINA^1,2

BIOCELL, Vol.48, No.11, pp. 1517-1520, 2024, DOI:10.32604/biocell.2024.055513 - 07 November 2024

Abstract This article navigates the relationship between biomaterials and osteogenic cell adhesion, highlighting the importance of mimicking the physiological response for bone tissue regeneration. Within this spirit is an initial description of the interaction between osteoblasts and osteoprogenitor cells with the extracellular matrix, explaining the leading role of integrins and cadherins in cell adhesion, and the intracellular signaling pathways elicited. Additionally, there is a focus on the strategies of advanced biomaterials that foster osteogenesis by replicating the native environment, taking advantage of these known specific signaling pathways. The final remarks lay on the need for careful More >

PINGHUA TU, SHANSHAN WANG, KELAN DENG, XINJUN LI, ZHANLING WU^*

BIOCELL, Vol.48, No.11, pp. 1603-1612, 2024, DOI:10.32604/biocell.2024.054364 - 07 November 2024

Abstract Objectives: The antitumor effects of pyropheophorbide-α methyl ester-mediated photodynamic therapy (MPPa-PDT) were observed in several cancers. The objective of this investigation was to examine the antineoplastic efficacy of MPPa-PDT acting on lung carcinoma A549 cells and further elaborate mechanisms. Methods: The viability of A549 cells was examined with cell counting kit-8 after MPPa-PDT disposal. Hoechst 33342 staining, monodansylcadaverine (MDC) staining, and transmission electron microscopy were employed to observe apoptotic bodies and autophagic vesicles. Flow cytometry with Annexin V/propidium iodide (PI) labeling objectively assessed cell death. The expression of associated proteins, including Caspase-3, Beclin-1, LC-3II, and More > Graphic Abstract

HAO WU^#, NA HUO^#, SITUO WANG, ZIWEI LIU, YI JIANG^*, QUAN SHI^*

BIOCELL, Vol.48, No.11, pp. 1531-1542, 2024, DOI:10.32604/biocell.2024.054278 - 07 November 2024

Abstract Stem cells have shown great application potential in wound repair, tissue regeneration, and disease treatment. Therefore, a full understanding of stem cells and their related regulatory mechanisms in disease treatment is conducive to improving the therapeutic effect of stem cells. However, thus far, there are still many unsolved mysteries in the field of stem cells due to technical limitations, which hinder the in-depth exploration of stem cells and their wide clinical application. Single-cell sequencing (SCS) has provided very powerful and unbiased insights into cell gene expression profiles at the single-cell level, bringing exciting results to More >