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  • Open Access

    ARTICLE

    Applying an Ordinal Priority Approach Based Neutrosophic Fuzzy Axiomatic Design Approach to Develop Sustainable Geothermal Energy Source

    Chia-Nan Wang, Thuy-Duong Thi Pham*, Nhat-Luong Nhieu

    Energy Engineering, Vol.121, No.8, pp. 2039-2064, 2024, DOI:10.32604/ee.2024.050224

    Abstract Geothermal energy is considered a renewable, environmentally friendly, especially carbon-free, sustainable energy source that can solve the problem of climate change. In general, countries with geothermal energy resources are the ones going through the ring of fire. Therefore, not every country is lucky enough to own this resource. As a country with 117 active volcanoes and within the world’s ring of fire, it is a country whose geothermal resources are estimated to be about 40% of the world’s geothermal energy potential. However, the percentage used compared to the geothermal potential is too small. Therefore, this… More >

  • Open Access

    ARTICLE

    Adsorption of Malachite Green Using Activated Carbon from Mangosteen Peel: Optimization Using Box-Behnken Design

    Nabila Eka Yuningsih, Latifa Ariani, Suprapto Suprapto, Ita Ulfin, Harmami Harmami, Hendro Juwono, Yatim Lailun Ni’mah*

    Journal of Renewable Materials, Vol.12, No.5, pp. 981-992, 2024, DOI:10.32604/jrm.2024.049109

    Abstract In this research, activated carbon from mangosteen peel has been synthesized using sulfuric acid as an activator. The adsorption performance of the activated carbon was optimized using malachite green dye as absorbate. Malachite green dye waste is a toxic and non-biodegradable material that damages the environment. Optimization of adsorption processes was carried out using Response Surface Methodology (RSM) with a Box-Behnken Design (BBD). The synthesized activated carbon was characterized using FTIR and SEM instruments. The FTIR spectra confirmed the presence of a sulfonate group (-SOH) in the activated carbon, indicating that the activation process using… More >

  • Open Access

    ARTICLE

    Numerical Investigations on Fluid Flow and Heat Transfer Characteristics of an Ultra-Thin Heat Pipe with Separated Wick Structures

    Yasushi Koito1,*, Akira Fukushima2

    Frontiers in Heat and Mass Transfer, Vol.22, No.3, pp. 869-887, 2024, DOI:10.32604/fhmt.2024.050910

    Abstract Thermal and fluid-flow characteristics were numerically analyzed for ultra-thin heat pipes. Many studies have been conducted for ultra-thin heat pipes with a centered wick structure, but this study focused on separated wick structures to increase the evaporation/condensation surface areas within the heat pipe and to reduce the concentration of heat flux within the wick structure. A mathematical heat-pipe model was made in the three-dimensional coordinate system, and the model consisted of three regions: a vapor channel, liquid-wick, and container wall regions. The conservation equations for mass, momentum, and energy were solved numerically with boundary conditions… More >

  • Open Access

    ARTICLE

    Impact Performance Research of Re-Entrant Octagonal Negative Poisson’s Ratio Honeycomb with Gradient Design

    Yiyuan Li1, Yongjing Li1,2, Shilin Yan1,2,*, Pin Wen1,2,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 3105-3119, 2024, DOI:10.32604/cmes.2024.051375

    Abstract Based on the traditional re-entrant honeycomb, a novel re-entrant octagon honeycomb (ROH) is proposed. The deformation mode of the honeycomb under quasi-static compression is analyzed by numerical simulation, and the results are in good agreement with the experimental ones. The deformation modes, mechanical properties, and energy absorption characteristics of ROH along the impact and perpendicular directions gradient design are investigated under different velocities. The results indicated that the deformation mode of ROH is affected by gradient design along the direction of impact and impact speed. In addition, gradient design along the direction of impact can… More >

  • Open Access

    ARTICLE

    Oleanolic acid inhibits colon cancer cell stemness and reverses chemoresistance by suppressing JAK2/STAT3 signaling pathway

    RUOYU CHEN1, YIMAN WU1, FENG WANG1, JUNTAO ZHOU1, HUAZHANG ZHUANG1, WEI LI2,*

    BIOCELL, Vol.48, No.7, pp. 1037-1046, 2024, DOI:10.32604/biocell.2024.051074

    Abstract Background: Oleanolic acid (OA), a pentacyclic triterpenoid exhibiting specific anti-cancer properties and highly effective antioxidant activity, was isolated from traditional Chinese medicinal herbs. Conversely, the OA that impacts colon cancer (CC) cells and its underlying mechanisms remain poorly understood. Methods: The cytotoxic effect of OA alone or OA-5-Fluorouracil (5-FU) combination on normal and CC cells was analyzed by methyl thiazolyl diphenyl-tetrazolium bromide (MTT). Then, the impact of OA on CC cell lines (LoVo and HT-29) proliferation and stemness were measured using colon formation and tumorsphere formation assays. Octamer-binding transcription factor 4 (Oct4), Prominin-1 (CD133), Nanog,… More >

  • Open Access

    ARTICLE

    Sciadopitysin exerts anticancer effects on HepG2 hepatocellular carcinoma cells by regulating reactive oxygen species-mediated signaling pathways

    YAN-NAN LI1,#, YUN-HONG XIU2,#, YAN-JUN TANG3, JING-LONG CAO1, WEN-SHUANG HOU1, AN-QI WANG1, TIAN-ZHU LI4,*, CHENG-HAO JIN1,3,5,*

    BIOCELL, Vol.48, No.7, pp. 1055-1069, 2024, DOI:10.32604/biocell.2024.050515

    Abstract Objectives: Sciadopitysin (SP) is a flavonoid in Ginkgo biloba that exhibits various pharmacological activities. This study aimed to investigate its antitumor effects and the underlying molecular mechanism of SP in hepatocellular carcinoma (HCC) cells. Methods: Network pharmacology was used for target prediction analysis. Cell Counting Kit-8 (CCK-8) assay was used to test the cell viability. Flow cytometry was used to test the cell cycle distribution, apoptosis status, and reactive oxygen species (ROS) levels. Transwell and wound-healing assay was used to test the migration effect of SP on HepG2 cells. Western Blot assay was used to… More > Graphic Abstract

    Sciadopitysin exerts anticancer effects on HepG2 hepatocellular carcinoma cells by regulating reactive oxygen species-mediated signaling pathways

  • Open Access

    ARTICLE

    Cholic acid mitigates osteoarthritis by inhibiting the NF-κB/PERK/SIRT1 signaling pathway

    JIAOE SHENG1, ZUMIN YI2, SANSHAN HE1, QINGCHAO WU1, XIA HUANG1, GUOQING YAN1, YUFANG DAI1,*, LINCHONG SU1,*

    BIOCELL, Vol.48, No.7, pp. 1095-1104, 2024, DOI:10.32604/biocell.2024.028421

    Abstract Introduction: Cholic acid (CA) is a natural steroid useful in treating chronic bronchitis and cholecystitis. On the other hand, its potential impact on osteoarthritis (OA) is unknown. Objective: Using an in vitro and in vivo osteoarthritis model, we sought to assess the chondroprotective properties of CA. Methods: We employed the Cell Counting Kit-8 to measure the impact of CA on chondrocyte activity to assess the toxicity of the cells. Multiple molecular biology experimental techniques were used to investigate potential signaling pathways that CA may use to prevent inflammation and give chondrocytes protection. Furthermore, how CA affects the OA… More >

  • Open Access

    ARTICLE

    Optimal Design of High-Speed Partial Flow Pumps using Orthogonal Tests and Numerical Simulations

    Jiaqiong Wang1,2, Tao Yang1, Chen Hu1, Yu Zhang3,*, Ling Zhou1,2

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.6, pp. 1203-1218, 2024, DOI:10.32604/fdmp.2023.045825

    Abstract To investigate the influence of structural parameters on the performances and internal flow characteristics of partial flow pumps at a low specific speed of 10000 rpm, special attention was paid to the first and second stage impeller guide vanes. Moreover, the impeller blade outlet width, impeller inlet diameter, blade inclination angle, and number of blades were considered for orthogonal tests. Accordingly, nine groups of design solutions were formed, and then used as a basis for the execution of numerical simulations (CFD) aimed at obtaining the efficiency values and heads for each design solution group. The More >

  • Open Access

    ARTICLE

    Optimizing Hybrid Fibre-Reinforced Polymer Bars Design: A Machine Learning Approach

    Aneel Manan1, Pu Zhang1,*, Shoaib Ahmad2, Jawad Ahmad2

    Journal of Polymer Materials, Vol.41, No.1, pp. 15-44, 2024, DOI:10.32604/jpm.2024.053859

    Abstract Fiber-reinforced polymer (FRP) bars are gaining popularity as an alternative to steel reinforcement due to their advantages such as corrosion resistance and high strength-to-weight ratio. However, FRP has a lower modulus of elasticity compared to steel. Therefore, special attention is required in structural design to address deflection related issues and ensure ductile failure. This research explores the use of machine learning algorithms such as gene expression programming (GEP) to develop a simple and effective equation for predicting the elastic modulus of hybrid fiber-reinforced polymer (HFPR) bars. A comprehensive database of 125 experimental results of HFPR… More >

  • Open Access

    ARTICLE

    ROR2 promotes invasion and chemoresistance of triple-negative breast cancer cells by activating PI3K/AKT/mTOR signaling

    XIA DA1, HAN GE2, JUNFENG SHI3, CHUNHUA ZHU1, GUOZHU WANG1, YUAN FANG4,*, JIN XU1,*

    Oncology Research, Vol.32, No.7, pp. 1209-1219, 2024, DOI:10.32604/or.2024.045433

    Abstract Objective: This study aimed to investigate the role of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in triple-negative breast cancer (TNBC). Methods: ROR2 expression in primary TNBC and metastatic TNBC tissues was analyzed by immunohistochemical staining and PCR. ROR2 expression in TNBC cell lines was detected by PCR and Western blot analysis. The migration, invasion and chemosensitivity of TNBC cells with overexpression or knockdown of ROR2 were examined. Results: ROR2 expression was high in metastatic TNBC tissues. ROR2 knockdown suppressed the migration, invasion and chemoresistance of TNBC cells. ROR2 overexpression in MDA-MB-435 cells promoted the migration, More >

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