Ping Wu, Huatao Quan, Jing Kang, Jian He, Shi Luo, Chubo Xie, Jing Xu, Yaoyun Tang, Suping Zhao
Oncology Research, Vol.25, No.9, pp. 1479-1488, 2017, DOI:10.3727/096504017X14886420642823
Abstract Hypopharyngeal cancer (HPC) frequently presents at an advanced stage and displays early submucosal spread,
resulting in a poor prognosis. It is among the worst of all cancers in the head and neck subsites. Therefore,
detection of HPC at an earlier stage would be beneficial to patients. In this study, we used differential in-gel
electrophoresis (DIGE) and two-dimensional polyacrylamide gel electrophoresis (2-DE) proteomics analysis
to identify the potential biomarkers for HPC. Among the differential proteins identified, calcium-binding protein S100A9 was overexpressed in HPC tissues compared with normal adjacent tissues, and S100A9 expression in metastatic tissues and… More >
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