Gao Liu*, Tian Xiang†, Quan-Feng Wu‡, Wei-Xing Wang*
Oncology Research, Vol.23, No.3, pp. 99-107, 2015, DOI:10.3727/096504015X14496932933575
Abstract The lncRNA H19 and its mature product miR-675 have recently been shown to be upregulated and promote the
progression of gastric cancer. However, the detailed function and underlying molecular mechanism of H19/miR-
675 in the carcinogenesis of gastric cancer remains unclear. In this study, we found that H19 depended on miR-
675 to enhance the proliferation and invasion of gastric cancer AGS cells, and the expression of miR-675 was
positively correlated with H19 in patients with gastric cancer. Subsequently, the tumor-suppressor runt domain
transcription factor 1 (RUNX1) was confirmed to be a downstream molecule of… More >
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