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    ARTICLE

    MicroRNA-152 Inhibits Cell Proliferation, Migration, and Invasion in Breast Cancer

    Adilijiang Maimaitiming*, Ailijiang Wusiman, Abulajiang Aimudula, Xuekelaiti Kuerban*, Pengcheng Su*

    Oncology Research, Vol.28, No.1, pp. 13-19, 2020, DOI:10.3727/096504019X15519249902838

    Abstract The aim of the present study was to investigate the roles of microRNA-152 (miR-152) in the initiation and progression of breast cancer. The expression level of miR-152 was detected in human breast cancer tissue and a panel of human breast cancer cell lines using qRT-PCR. Results found that miR-152 expression was significantly downregulated in breast cancer tissue samples compared to adjacent noncancerous tissues as well as in breast cancer cell lines. Overexpression of miR-152 significantly suppressed breast cancer cell proliferation, migration, and invasion. Luciferase reporter assay results found that ROCK1 is a direct and functional More >

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