HaiYan Yang*†, ZhiGang Peng†, ZhenZhen Da*, Xin Li‡, YeXiao Cheng*, BinBin Tan§, Xin Xiang¶, HaiPing Zheng†, Yan Li*, LanHua Chen*, Ning Mo†, XueXin Yan†, Xiaolin Li*, XiaoHua Hu†
Oncology Research, Vol.25, No.8, pp. 1231-1243, 2017, DOI:10.3727/096504017X14850134190255
Abstract MicroRNAs (miRs) have been demonstrated to be involved in the development and progression of osteosarcoma (OS), but the molecular mechanism still remains to be fully investigated. The present study investigated
the function of miR-148a in OS, as well as its underlying mechanism. Our data showed that miR-148a was
significantly downregulated in OS tissues compared to their matched adjacent normal tissues, and also in OS
cell lines compared to normal human osteoblast cells. Low expression of miR-148a was significantly associated
with tumor progression and a poor prognosis for OS patients. Rho-associated coiled-coil kinase 1 (ROCK1) was… More >
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