Wen-Shou Tan^1,#, Hsuan Kuo^2,#, Chang-Ge Jiang¹, Mei-Han Lu¹, Yi-He Lu¹, Yung-Li Wang¹, Ching-Shuen Wang¹, Thi Thuy Tien Vo³, I-Ta Lee^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070871 - 30 December 2025

Abstract This narrative review examines recent advances in salivary biomarkers for oral squamous cell carcinoma (OSCC), a major subtype of oral cancer with persistently low five-year survival rates due to delayed diagnosis. Saliva has emerged as a noninvasive diagnostic medium capable of reflecting both local tumor activity and systemic physiological changes. Various salivary biomarkers, including microRNAs, cytokines, proteins, metabolites, and exosomes, have been linked to oncogenic signaling pathways involved in tumor progression, immune modulation, and therapeutic resistance. Advances in quantitative polymerase chain reaction, mass spectrometry, and next-generation sequencing have enabled comprehensive biomarker profiling, while point-of-care detection More >

Jing Shan¹, Catherine King^2,3, Harunor Rashid^3,4, Veysel Kayser^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070851 - 30 December 2025

Abstract Objectives: B-cell maturation antigen (BCMA)-targeted antibody–drug conjugates (ADCs) have emerged as promising therapies for relapsed/refractory multiple myeloma (RRMM), but the overall efficacy and safety profile is unclear. This study aimed to synthesize the available evidence on the safety and efficacy of BCMA-ADCs in development for RRMM. Methods: A systematic search was conducted using six bibliographic databases and ClinicalTrials.gov up to November 2024. Studies were eligible if they were human clinical trials or animal studies evaluating BCMA-ADCs and reported efficacy and safety outcomes. Data extraction and quality assessments were conducted using validated tools, including ROBINS-I… More >

Giacomo Iovane^1,*, Luca Traman², Michele Maffezzoli^1,3, Giuseppe Fornarini², Domenico Corradi⁴, Debora Guareschi⁴, Matteo Santoni^5,#, Sebastiano Buti^1,#

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070523 - 30 December 2025

Abstract Background: While the treatment of metastatic renal cell carcinoma (mRCC) is evolving due to immune checkpoint inhibitors (ICIs), optimal strategies for later lines of therapy have yet to be defined. The combination of lenvatinib and everolimus represents a viable option, and the present review aimed to summarize its activity, effectiveness, and safety. Methods: A systematic review of the literature was conducted using PubMed, targeting studies published between 2018 and 2025. Eligible studies included English-language prospective and retrospective trials reporting survival outcomes in mRCC patients treated with lenvatinib and everolimus after at least one ICI-containing regimen. Results:… More > Graphic Abstract

Samira Rastbod¹, Mehdi Jahangiri^2,*, Behrang Moradi¹, Haleh Nazari¹

Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.070089 - 27 December 2025

Abstract Curtain wall systems have evolved from aesthetic façade elements into multifunctional building envelopes that actively contribute to energy efficiency and climate responsiveness. This review presents a comprehensive examination of curtain walls from an energy-engineering perspective, highlighting their structural typologies (Stick and Unitized), material configurations, and integration with smart technologies such as electrochromic glazing, parametric design algorithms, and Building Management Systems (BMS). The study explores the thermal, acoustic, and solar performance of curtain walls across various climatic zones, supported by comparative analyses and iconic case studies including Apple Park, Burj Khalifa, and Milad Tower. Key challenges—including… More > Graphic Abstract

Meenakshi Aggarwal¹, Vikas Khullar^2,*, Nitin Goyal³

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-31, 2026, DOI:10.32604/cmc.2025.072673 - 09 December 2025

Abstract The Internet of Vehicles, or IoV, is expected to lessen pollution, ease traffic, and increase road safety. IoV entities’ interconnectedness, however, raises the possibility of cyberattacks, which can have detrimental effects. IoV systems typically send massive volumes of raw data to central servers, which may raise privacy issues. Additionally, model training on IoV devices with limited resources normally leads to slower training times and reduced service quality. We discuss a privacy-preserving Federated Split Learning with Tiny Machine Learning (TinyML) approach, which operates on IoV edge devices without sharing sensitive raw data. Specifically, we focus on… More >

Shaoping Xiao^1,*, Zhaoan Wang¹, Junchao Li², Caden Noeller¹, Jiefeng Jiang³, Jun Wang⁴

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-62, 2026, DOI:10.32604/cmc.2025.072146 - 09 December 2025

Abstract The integration of human factors into artificial intelligence (AI) systems has emerged as a critical research frontier, particularly in reinforcement learning (RL), where human-AI interaction (HAII) presents both opportunities and challenges. As RL continues to demonstrate remarkable success in model-free and partially observable environments, its real-world deployment increasingly requires effective collaboration with human operators and stakeholders. This article systematically examines HAII techniques in RL through both theoretical analysis and practical case studies. We establish a conceptual framework built upon three fundamental pillars of effective human-AI collaboration: computational trust modeling, system usability, and decision understandability. Our… More >

Lei Wang^1,2, Menghan Wei², Ziwei Huangfu³, Shunjie Zhu², Xuejian Ge^1,*, Zhengquan Li⁴

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-32, 2026, DOI:10.32604/cmc.2025.071295 - 09 December 2025

Abstract Iterative Learning Control (ILC) provides an effective framework for optimizing repetitive tasks, making it particularly suitable for high-precision applications in both precision manufacturing and intelligent transportation systems (ITS). This paper presents a systematic review of ILC’s developmental progress, current methodologies, and practical implementations across these two critical domains. The review first analyzes the key technical challenges encountered when integrating ILC into precision manufacturing workflows. Through case studies, it evaluates demonstrated improvements in positioning accuracy, surface finish quality, and production throughput. Furthermore, the study examines ILC’s applications in ITS, with particular focus on vehicular motion control More >

Qun Song¹, Chao Gao¹, Han Wu¹, Zhiheng Rao¹, Huafeng Qin^1,*, Simon Fong^1,2,*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-49, 2026, DOI:10.32604/cmc.2025.070918 - 09 December 2025

Abstract Metaheuristic algorithms, renowned for strong global search capabilities, are effective tools for solving complex optimization problems and show substantial potential in e-Health applications. This review provides a systematic overview of recent advancements in metaheuristic algorithms and highlights their applications in e-Health. We selected representative algorithms published between 2019 and 2024, and quantified their influence using an entropy-weighted method based on journal impact factors and citation counts. CThe Harris Hawks Optimizer (HHO) demonstrated the highest early citation impact. The study also examined applications in disease prediction models, clinical decision support, and intelligent health monitoring. Notably, the More >

Zhijie Lin¹, Chao Yang^1,2,*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-33, 2026, DOI:10.32604/cmc.2025.070735 - 09 December 2025

Abstract Sustainable aluminum alloys, renowned for their lower energy consumption and carbon emissions, present a critical path towards a circular materials economy. However, their design is fraught with challenges, including complex performance variability due to impurity elements and the time-consuming, cost-prohibitive nature of traditional trial-and-error methods. The high-dimensional parameter space in processing optimization and the reliance on human expertise for quality control further complicate their development. This paper provides a comprehensive review of Artificial Intelligence (AI) techniques applied to sustainable aluminum alloy design, analyzing their methodologies and identifying key challenges and optimization strategies. We review how… More >

Ahmed Abdel-Wahab¹, Mohammad Alkhatib^2,*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-34, 2026, DOI:10.32604/cmc.2025.070010 - 09 December 2025

Abstract Deepfake is a sort of fake media made by advanced AI methods like Generative Adversarial Networks (GANs). Deepfake technology has many useful uses in education and entertainment, but it also raises a lot of ethical, social, and security issues, such as identity theft, the dissemination of false information, and privacy violations. This study seeks to provide a comprehensive analysis of several methods for identifying and circumventing Deepfakes, with a particular focus on image-based Deepfakes. There are three main types of detection methods: classical, machine learning (ML) and deep learning (DL)-based, and hybrid methods. There are… More >