SIDDAVARAM NAGINI¹, PRATHAP REDDY KALLAMADI², KRANTHI KIRAN KISHORE TANAGALA³, GEEREDDY BHANUPRAKASH REDDY^2,*

Oncology Research, Vol.32, No.8, pp. 1287-1308, 2024, DOI:10.32604/or.2024.049918

Abstract Aldo-keto reductases (AKRs) are a superfamily of enzymes that play crucial roles in various cellular processes, including the metabolism of xenobiotics, steroids, and carbohydrates. A growing body of evidence has unveiled the involvement of AKRs in the development and progression of various cancers. AKRs are aberrantly expressed in a wide range of malignant tumors. Dysregulated expression of AKRs enables the acquisition of hallmark traits of cancer by activating oncogenic signaling pathways and contributing to chemoresistance. AKRs have emerged as promising oncotherapeutic targets given their pivotal role in cancer development and progression. Inhibition of aldose reductase… More >

MING ZHUANG, XUE ZHANG, LU LI, LIMING WEN, JIAMIN QIN^*

Oncology Research, Vol.32, No.8, pp. 1347-1357, 2024, DOI:10.32604/or.2024.046170

Abstract Hepatocellular carcinoma (HCC) poses a significant threat to human health. Resistance to sorafenib in the chemotherapy of HCC is a common and significant issue that profoundly impacts clinical treatment. While several members of the transmembrane (TMEM) protein family have been implicated in the occurrence and progression of HCC, the association between TMEM39b and HCC remains unexplored. This study revealed a significant overexpression of TMEM39b in HCC, which correlated with a poor prognosis. Subsequent investigation revealed that RAS-selective lethal 3 (RSL3) induced pronounced ferroptosis in HCC, and knocking down the expression of TMEM39b significantly decreased its More >

HAIQING HU^1,#,*, HAO YANG^2,#, SHUAISHUAI FAN³, XUE JIA³, YING ZHAO³, HONGRUI LI³

Oncology Research, Vol.32, No.8, pp. 1335-1346, 2024, DOI:10.32604/or.2024.044174

Abstract Long non-coding RNAs (lncRNAs) have been implicated in cancer progression and drug resistance development. Moreover, there is evidence that lncRNA HOX transcript antisense intergenic RNA (HOTAIR) is involved in colorectal cancer (CRC) progression. The present study aimed to examine the functional role of lncRNA HOTAIR in conferring radiotherapy resistance in CRC cells, as well as the underlying mechanism. The relative expression levels of HOTAIR were examined in 70 pairs of CRC tumor and para-cancerous tissues, as well as in radiosensitive and radioresistant samples. The correlations between HOTAIR expression levels and clinical features of patients with… More >

Kenta Hashimoto¹, Guohui Sun¹, Yasushi Koito^2,*

Frontiers in Heat and Mass Transfer, Vol.22, No.3, pp. 687-702, 2024, DOI:10.32604/fhmt.2024.052928

Abstract Centered or striped wick structures have been used to develop ultrathin heat pipes. Differing from traditional heat pipes, the centered or striped wick structures leave noncontact container surfaces with the wick structure. In this study, experiments and numerical analyses were conducted to investigate the influence of these noncontact surfaces. In the experiments, a strip-shaped wick structure was placed vertically, the top was sandwiched between wider rods and the bottom was immersed in a working fluid. The rod width was greater than the wick width; thus, noncontact surfaces were left between the rod and the wick… More >

RUOYU CHEN¹, YIMAN WU¹, FENG WANG¹, JUNTAO ZHOU¹, HUAZHANG ZHUANG¹, WEI LI^2,*

BIOCELL, Vol.48, No.7, pp. 1037-1046, 2024, DOI:10.32604/biocell.2024.051074

Abstract Background: Oleanolic acid (OA), a pentacyclic triterpenoid exhibiting specific anti-cancer properties and highly effective antioxidant activity, was isolated from traditional Chinese medicinal herbs. Conversely, the OA that impacts colon cancer (CC) cells and its underlying mechanisms remain poorly understood. Methods: The cytotoxic effect of OA alone or OA-5-Fluorouracil (5-FU) combination on normal and CC cells was analyzed by methyl thiazolyl diphenyl-tetrazolium bromide (MTT). Then, the impact of OA on CC cell lines (LoVo and HT-29) proliferation and stemness were measured using colon formation and tumorsphere formation assays. Octamer-binding transcription factor 4 (Oct4), Prominin-1 (CD133), Nanog,… More >

Wenwen Su^1,#, Chongpei Zheng^3,#, Zhencheng Han², Chunguang Ren¹, Di Wu¹, Tao Li¹, Yi Yang¹, Weijie Li^2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1249-1261, 2024, DOI:10.32604/phyton.2024.051935

Abstract Kiwifruit canker and brown spot are significant diseases affecting kiwis, caused by Pseudomonas syringae pathogenic variations (Pseudomonas syringae pv. Actinidiae (Psa)) and Corynesporapolytica (Corynespora cassiicola). At present, the research on canker disease and brown spot disease mainly focuses on the isolation and identification of pathogenic bacteria, drug control, resistance gene mining and functional verification. Practice has proved that breeding disease resistant varieties are an effective method to control canker disease and brown spot disease. However, most existing cultivars lack genes for canker and brown spot resistance. Wild kiwifruit resources in nature exhibit extensive genetic diversity due to prolonged natural selection,… More >

Binyang Zhao¹, Fengchan Wu², Guojun Cai³, Peiyu Xi², Yulin Guo², Anding Li^2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1345-1363, 2024, DOI:10.32604/phyton.2024.050950

Abstract In order to explore the response mechanism of Passiflora edulis Sims to drought stress, the changes in morphological and physiological traits of Passiflora edulis Sims under different drought conditions were studied. A total of 7 germplasm resources of Passiflora edulis Sims were selected and tested under drought stress by the pot culture method under 4 treatment levels: 75%–80% (Control, CK) of maximum field water capacity, 55%–60% (Light Drought, LD) of maximum field water capacity, i.e., mild drought, 40%–45% (Moderate Drought, MD) of maximum field water capacity, i.e., moderate drought and 30%–35% (Severe Drought, SD) of maximum field water… More >

Aneel Manan¹, Pu Zhang^1,*, Shoaib Ahmad², Jawad Ahmad²

Journal of Polymer Materials, Vol.41, No.1, pp. 15-44, 2024, DOI:10.32604/jpm.2024.053859

Abstract Fiber-reinforced polymer (FRP) bars are gaining popularity as an alternative to steel reinforcement due to their advantages such as corrosion resistance and high strength-to-weight ratio. However, FRP has a lower modulus of elasticity compared to steel. Therefore, special attention is required in structural design to address deflection related issues and ensure ductile failure. This research explores the use of machine learning algorithms such as gene expression programming (GEP) to develop a simple and effective equation for predicting the elastic modulus of hybrid fiber-reinforced polymer (HFPR) bars. A comprehensive database of 125 experimental results of HFPR… More >

XIA DA¹, HAN GE², JUNFENG SHI³, CHUNHUA ZHU¹, GUOZHU WANG¹, YUAN FANG^4,*, JIN XU^1,*

Oncology Research, Vol.32, No.7, pp. 1209-1219, 2024, DOI:10.32604/or.2024.045433

Abstract Objective: This study aimed to investigate the role of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in triple-negative breast cancer (TNBC). Methods: ROR2 expression in primary TNBC and metastatic TNBC tissues was analyzed by immunohistochemical staining and PCR. ROR2 expression in TNBC cell lines was detected by PCR and Western blot analysis. The migration, invasion and chemosensitivity of TNBC cells with overexpression or knockdown of ROR2 were examined. Results: ROR2 expression was high in metastatic TNBC tissues. ROR2 knockdown suppressed the migration, invasion and chemoresistance of TNBC cells. ROR2 overexpression in MDA-MB-435 cells promoted the migration, More >

Lian Liu^1,2, Liang Li^1,2, Kebo Jiao^1,2,*, Junwei Fang^1,2, Yun Luo^1,2

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.5, pp. 975-987, 2024, DOI:10.32604/fdmp.2023.030109

Abstract Ultra-deep reservoirs play an important role at present in fossil energy exploitation. Due to the related high temperature, high pressure, and high formation fracture pressure, however, methods for oil well stimulation do not produce satisfactory results when conventional fracturing fluids with a low pumping rate are used. In response to the above problem, a fracturing fluid with a density of 1.2~1.4 g/cm was developed by using Potassium formatted, hydroxypropyl guanidine gum and zirconium crosslinking agents. The fracturing fluid was tested and its ability to maintain a viscosity of 100 mPa.s over more than 60 min More >