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  • Open Access

    ARTICLE

    ZBTB7/miR-137 Autoregulatory Circuit Promotes the Progression of Renal Carcinoma

    Lihui Wang, Qi Li, Zhuo Ye, Baoping Qiao

    Oncology Research, Vol.27, No.9, pp. 1007-1014, 2019, DOI:10.3727/096504018X15231148037228

    Abstract Renal carcinoma greatly threatens human health, but the involved molecular mechanisms are far from complete understanding. As a master oncogene driving the initiation of many other cancers, ZBTB7 has not been established to be associated with renal cancer. Our data revealed that ZBTB7 is highly expressed in renal carcinoma specimens and cell lines, compared with normal cells. The silencing of ZBTB7 suppressed the proliferation and invasion of renal cancer cells. ZBTB7 overexpression rendered normal cells with higher proliferation rates and invasiveness. An animal study further confirmed the role of ZBTB7 in the growth of renal More >

  • Open Access

    ARTICLE

    Amentoflavone Suppresses Cell Growth and Invasion in Renal Carcinoma Cells by Activating PPARγ

    Kun Fan1,2, Xiaofu Qiu2, Yu Fu2, Kangjian Lin, Huanhui Li2, Guosheng Yang *,1,2

    Molecular & Cellular Biomechanics, Vol.14, No.1, pp. 33-45, 2017, DOI:10.3970/mcb.2017.014.035

    Abstract This study intends to investigate the role of amentoflavone(AF) in human clear-cell renal cell carcinoma (ccRCC) and to elucidate underlying molecular mechanisms. Materials and Methods: Human RCC cell lines Caki-1 and 786-O were used in this study. Cell proliferation, apoptosis, cell cycle distribution and invasion assays were conducted to analyze the effect of AF against ccRCC in vitro. Xenograft model and pulmonary metastasis animal model were established to evaluate the vivo therapeutic efficacy and against pulmonary metastasis ability of AF, respectively. Results: Our findings revealed that AF selectively suppressed tumor cell proliferation in a dose- and More >

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