GABOR XANTUS1,*, BALINT KISS2, GYULA MOLNAR2, CANDICE MATHESON3, V. ANNA GYARMATHY4, PETER L. KANIZSAI5
BIOCELL, Vol.45, No.3, pp. 445-449, 2021, DOI:10.32604/biocell.2021.014754
- 03 March 2021
Abstract For about a quarter of a century, monitoring lactate levels and/or lactate clearance has been an unquestionable cornerstone in sepsis management. The elevated lactate level appeared to be an independent predictor of mortality, and the consequent metabolic acidosis was thought to explain a number of pathophysiological changes seen in septic shock. Recent physiological and clinical findings seem to challenge the adverse role of lactic acidosis in sepsis. Evidence suggests that lactate levels are not necessarily directly proportional to either tissue or cellular hypoxia, and conversely, despite high lactate levels, increased peripheral tissue oxygen pressure can… More >
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