DAN GUO¹, XI XIA^2,*, JIAN YANG^1,*

BIOCELL, Vol.48, No.7, pp. 1023-1036, 2024, DOI:10.32604/biocell.2024.051095

Abstract Liver regeneration and the development of effective therapies for liver failure remain formidable challenges in modern medicine. In recent years, the utilization of 3D cell-based strategies has emerged as a promising approach for addressing these urgent clinical requirements. This review provides a thorough analysis of the application of 3D cell-based approaches to liver regeneration and their potential impact on patients with end-stage liver failure. Here, we discuss various 3D culture models that incorporate hepatocytes and stem cells to restore liver function and ameliorate the consequences of liver failure. Furthermore, we explored the challenges in transitioning More >

XULONG SUN^1,#, WENTAO DING^2,#, CHAO JIANG³, ZHIAN FANG^4,*

BIOCELL, Vol.48, No.7, pp. 1071-1079, 2024, DOI:10.32604/biocell.2024.050519

Abstract Introduction: Hepatocellular carcinoma (HCC), a prevalent malignancy, poses significant challenges with high tumor heterogeneity and poor prognosis. MicroRNAs (miRNAs) play a pivotal role in hepatocarcinogenesis. Although abnormalities in microRNA-557 (miR-557) expression have been implicated in various cancer types, its role in HCC remains unclear. Therefore, there is a need to explore the function of microRNA-557 in HCC. Methods: Candidate miRNAs were identified through screening in GSE108724 and GSE20077. Real-time PCR was employed to analyze the expression level of miR-557 in hepatoma cell lines and tissues. Cell viability and migration assays were applied to assess the… More > Graphic Abstract

YAN-NAN LI^1,#, YUN-HONG XIU^2,#, YAN-JUN TANG³, JING-LONG CAO¹, WEN-SHUANG HOU¹, AN-QI WANG¹, TIAN-ZHU LI^4,*, CHENG-HAO JIN^1,3,5,*

BIOCELL, Vol.48, No.7, pp. 1055-1069, 2024, DOI:10.32604/biocell.2024.050515

Abstract Objectives: Sciadopitysin (SP) is a flavonoid in Ginkgo biloba that exhibits various pharmacological activities. This study aimed to investigate its antitumor effects and the underlying molecular mechanism of SP in hepatocellular carcinoma (HCC) cells. Methods: Network pharmacology was used for target prediction analysis. Cell Counting Kit-8 (CCK-8) assay was used to test the cell viability. Flow cytometry was used to test the cell cycle distribution, apoptosis status, and reactive oxygen species (ROS) levels. Transwell and wound-healing assay was used to test the migration effect of SP on HepG2 cells. Western Blot assay was used to… More > Graphic Abstract

CHUNLING LIANG^1,#, JING CHEN^2,#, XIAOJIE CHEN¹, WEI YAN³, JIE YU^4,*

BIOCELL, Vol.48, No.7, pp. 1105-1113, 2024, DOI:10.32604/biocell.2024.050509

Abstract Background: A differential gene, triggering receptor expressed on myeloid cells 1 (TREM1), was identified in blood sequencing datasets from myocardial infarction patients and healthy controls. Myocardial fibrosis following myocardial infarction significantly contributes to cardiac dysfunction. Objectives: This study aimed to unveil the intrinsic regulatory mechanism of TREM1 in myocardial fibrosis. Methods: Mimicking pathology by angiotensin II (Ang II) treatment of human cardiac fibroblasts (HCFs), the impacts of TREM1 knockdown on its proliferation, migration, and secretion of the pro-fibrotic matrix were identified. Using the Human Transcription Factor Database (HumanTFDB) website, lysine-specific demethylase 5B (KDM5B) was found to… More >

JUN-FENG ZHAO^1,†, YI-RAN JIANG^2,†, TIAN-LIN GUO¹, YONG-QING JIAO^1,*, XUN WANG^1,*

BIOCELL, Vol.48, No.7, pp. 1011-1022, 2024, DOI:10.32604/biocell.2024.050120

Abstract Neurodegenerative diseases constitute a broad category of diseases caused by the degeneration of the neurons. They are mainly manifested by the gradual loss of neuron structure and function and eventually can cause death or loss of neurons. As the global population ages rapidly, increased people are being diagnosed with neurodegenerative diseases. It has been established that the onset of Alzheimer’s disease (AD) is closely linked with increasing age and its major pathological features include amyloid-beta plaques (Aβ), Tau hyperphosphorylation, Neurofibrillary tangles (NFTs), neuronal death as well as synaptic loss. The involvement of microglia is crucial… More >

Yuanqing He^*, Xinyue Yu, Yu Xia, Yanhua Cao

International Journal of Mental Health Promotion, Vol.26, No.6, pp. 463-474, 2024, DOI:10.32604/ijmhp.2024.051909

Abstract Background: Teacher burnout is a serious issue in the field of education, particularly in early childhood education, where teachers face high levels of work stress and emotional labor, leading to emotional exhaustion and job burnout. However, past research has not sufficiently explored the mechanisms of social skills, empathy, and mindfulness in mitigating teacher burnout. Therefore, this study aims to investigate the relationship between preschool teachers’ social skills, empathy, and mindfulness with job burnout, in order to provide theoretical basis and practical guidance for reducing teacher burnout. Methods: This research utilized a convenience sampling approach to… More >

Shuai Lv^1,2, Zhaojun Chen^2,3, Jian Mao⁴, Hui Wang^2,5,*, Peibo Wu², Yujuan Hai¹

International Journal of Mental Health Promotion, Vol.26, No.6, pp. 491-498, 2024, DOI:10.32604/ijmhp.2024.048917

Abstract Objectives: To explore the relationship between college students’ self-esteem (SE) and their social phobia (SP), as well as the mediating role of fear of negative evaluation (FNE) and the moderating effect of perfectionism. Methods: A convenience sampling survey was carried out for 1020 college students from Shandong Province of China, utilizing measures of college students’ self-esteem, fear of negative evaluation, perfectionism, and social phobia. Data analysis was performed using the SPSS PROCESS macro. Results: (1) college students’ self-esteem significantly and negatively predicts their social phobia (β = −0.31, t = −10.10, p < 0.001); (2) fear of More >

Riwa Mahai¹, Rongpeng Liu¹, Xiaolang Du¹, Zejing Mu¹, Xiaoyun Wang^1,*, Jun Yuan^2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1203-1219, 2024, DOI:10.32604/phyton.2024.051559

Abstract Rosaceae represents a vast and complex group of species, with its classification being intricate and contentious. The taxonomic placement of many species within this family has been a subject of ongoing debate. The study utilized the Illumina platform to sequence 19 plant species from 10 genera in the Rosaceae. The cp genomes, varying in size from 153,366 to 159,895 bp, followed the typical quadripartite organization consisting of a large single-copy (LSC) region (84,545 to 87,883 bp), a small single-copy (SSC) region (18,174 to 19,259 bp), and a pair of inverted repeat (IR) regions (25,310 to… More >

Jin Tao¹, Jiatai Tian¹, Dongmei Li¹, Jinlei Zhu², Qun Ma³, Zhiming Zhang¹, Jungang Chen⁴, Yipeng Liu⁵, Jianqiang Qian^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1129-1141, 2024, DOI:10.32604/phyton.2024.051405

Abstract Human activities and industrialization have significantly increased soil nutrients, such as nitrogen (N) and phosphorus (P), profoundly impacting the composition and structure of plant community, as well as the ecosystem functions, especially in nutrient-limited ecosystems. However, as the key propagule pool of perennial grasslands, how belowground bud bank and its relationship with aboveground vegetation respond to short-term changes in soil nutrients was still unclear. In this study, we conducted a short-term (2021–2022) soil fertilization experiment with N addition (10 g N m yr) and P addition (5 g N m yr) in the meadow steppe… More >

Chuang Liu^1,2, Jing Xie², Hao Liu², Can Zhong², Gen Pan², Shuihan Zhang², Jian Jin^2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1221-1236, 2024, DOI:10.32604/phyton.2024.050759

Abstract Medicinal plants have aroused considerable interest as an alternative to chemical drugs due to the beneficial effects of their active secondary metabolites. However, the extensive use of chemical fertilizers and pesticides in pursuit of yield has caused serious pollution to the environment, which is not conducive to sustainable development in the field of medicinal plants. Microbial fertilizers are a type of “green fertilizer” containing specific microorganisms that can improve the soil microbial structure, enhance plant resistance to biological and abiotic stresses, and increase the yield of medicinal plants. The root exudates of medicinal plants attract… More >