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  • Open Access

    ARTICLE

    Erlotinib-Associated Rash in Advanced Non-Small Cell Lung Cancer: Relation to Clinicopathological Characteristics, Treatment Response, and Survival

    Ilias Kainis*, Nikolaos Syrigos*, Alexandra Kopitopoulou*, Ioannis Gkiozos*, Effrosyni Filiou*, Vasiliki Nikolaou*, Evangelia Papadavid

    Oncology Research, Vol.26, No.1, pp. 59-69, 2018, DOI:10.3727/096504017X14913452320194

    Abstract Systematic treatment of advanced non-small cell lung cancer (NSCLC) includes targeted treatment with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). The development of skin rash and its intensity have been associated with EGFR TKI’s efficacy. The main purpose of this study was to further investigate the potential value of erlotinib-associated rash as a predictor of prognosis and treatment response in a real-world cohort of patients with advanced NSCLC. The medical records of all NSCLC patients treated with erlotinib at the Oncology Unit of GPP, Sotiria Athens General Hospital between January 1, 2014 and… More >

  • Open Access

    ARTICLE

    AN AXISYMMETRIC MODEL FOR SOLID-LIQUID-VAPOR PHASE CHANGE IN THIN METAL FILMS INDUCED BY AN ULTRASHORT LASER PULSE

    Jing Huang, Kapil Baheti, J. K. Chen*, Yuwen Zhang

    Frontiers in Heat and Mass Transfer, Vol.2, No.1, pp. 1-10, 2011, DOI:10.5098/hmt.v2.1.3005

    Abstract An axisymmetric model for thermal transport in thin metal films irradiated by an ultrashort laser pulse was developed. The superheating phenomena including preheating, melting, vaporization and re-solidification were modeled and analyzed. Together with the energy balance, nucleation dynamics was employed iteratively to track the solid-liquid interface and the gas kinetics law was used iteratively to track the liquid-vapor interface. The numerical results showed that higher laser fluence and shorter pulse width lead to higher interfacial temperature, larger melting and ablation depths. A simplified 1-D model could overestimate temperature response and ablation depth due to the More >

  • Open Access

    ARTICLE

    Crashworthiness Design and Multi-Objective Optimization of Bionic Thin-Walled Hybrid Tube Structures

    Pingfan Li, Jiumei Xiao*

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.1, pp. 999-1016, 2024, DOI:10.32604/cmes.2023.044059

    Abstract Thin-walled structures are widely used in cars due to their lightweight construction and energy-absorbing properties. However, issues such as high initial stress and low energy-absorbing efficiency arise. This study proposes a novel energy-absorbing structure in which a straight tube is combined with a conical tube and a bamboo-inspired bulkhead structure is introduced. This configuration allows the conical tube to flip outward first and then fold together with the straight tube. This deformation mode absorbs more energy and less peak force than the conical tube sinking and flipping inward. Through finite element numerical simulation, the specific More >

  • Open Access

    PROCEEDINGS

    Explicit Dynamics Simulation and Design of Sandwich Composite Structures Reinforced by Multilayer Lattice

    Yadong Zhou1,*, Yile Zhang1

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.25, No.4, pp. 1-1, 2023, DOI:10.32604/icces.2023.09333

    Abstract Dynamic simulation and design of complex composite structures with energy-absorbing lattice are critically important for aircraft applications. In this study, high-velocity impact behaviors (deformation and damage modes) of sandwich composite structures with multilayer lattice are numerically studied by using explicit dynamics computation. First, the modeling strategy for sandwich composite panels with the multilayer lattice and foam core is developed by using Finite Element Method (FEM). In FEM model, the beam, shell, and solid elements are applied together for both the computational accuracy and efficiency. The unit cell model of the lattice is used considering the More >

  • Open Access

    ARTICLE

    FLOW AND HEAT TRANSFER OF CARBON NANOFLUIDS OVER A VERTICAL PLATE

    Mahantesh M Nandeppanavara,*, S. Shakunthalab

    Frontiers in Heat and Mass Transfer, Vol.9, pp. 1-10, 2017, DOI:10.5098/hmt.9.27

    Abstract In this paper, the buoyancy effect on flow and heat transfer characteristics of nanofluid in presence of carbon nanotubes due to a vertical plate is investigated. The obtained nonlinear PDE’s are converted to the non-linear ordinary differential equations by applying the similarity transformations corresponding to the boundary conditions. These boundary value problems are solved numerically using fourth order Runge-kutta method together with the efficient shooting iteration scheme. The nature of the flow and heat transfer are plotted and discussed in detail. It is noticed that buoyancy effect is very useful in cooling the system and More >

  • Open Access

    ARTICLE

    A Deep Trash Classification Model on Raspberry Pi 4

    Thien Khai Tran1, Kha Tu Huynh2,*, Dac-Nhuong Le3, Muhammad Arif4, Hoa Minh Dinh1

    Intelligent Automation & Soft Computing, Vol.35, No.2, pp. 2479-2491, 2023, DOI:10.32604/iasc.2023.029078

    Abstract Environmental pollution has had substantial impacts on human life, and trash is one of the main sources of such pollution in most countries. Trash classification from a collection of trash images can limit the overloading of garbage disposal systems and efficiently promote recycling activities; thus, development of such a classification system is topical and urgent. This paper proposed an effective trash classification system that relies on a classification module embedded in a hard-ware setup to classify trash in real time. An image dataset is first augmented to enhance the images before classifying them as either… More >

  • Open Access

    ARTICLE

    Object Detection Learning for Intelligent Self Automated Vehicles

    Ahtsham Alam1, Syed Ahmed Abdullah1, Israr Akhter1, Suliman A. Alsuhibany2,*, Yazeed Yasin Ghadi3, Tamara al Shloul4, Ahmad Jalal1

    Intelligent Automation & Soft Computing, Vol.34, No.2, pp. 941-955, 2022, DOI:10.32604/iasc.2022.024840

    Abstract Robotics is a part of today's communication that makes human life simpler in the day-to-day aspect. Therefore, we are supporting this cause by making a smart city project that is based on Artificial Intelligence, image processing, and some touch of hardware such as robotics. In particular, we advocate a self automation device (i.e., autonomous car) that performs actions and takes choices on its very own intelligence with the assist of sensors. Sensors are key additives for developing and upgrading all forms of self-sustaining cars considering they could offer the information required to understand the encircling… More >

  • Open Access

    ARTICLE

    Preliminary Archaeoacoustic Study of Kanheri Caves in Mumbai (Maharashtra, India)

    Ajinkya S. Umbarkar1,*, Deoram V. Nandanwar1, Omprakash P. Chimankar2

    Sound & Vibration, Vol.56, No.2, pp. 193-203, 2022, DOI:10.32604/sv.2022.015322

    Abstract Here we report first ever study on acoustical evaluation of Kanheri Caves located in Sanjay Gandhi National Park, Mumbai (Maharashtra, India). These caves are dated to a period between 2nd century BCE to 7th century CE. In this study we used an ambisonic recorder to capture Impulse Response, which carries acoustic signature of the place. Out of total 109 caves 41 were surveyed in available time. Out of those reverberant environment was noted in 12 caves. Measurements were made only in 3 caves (Cave Nos. 1, 3, 11) which are important. In the beginning we carried… More >

  • Open Access

    ARTICLE

    Crashworthiness Design and Multi-Objective Optimization for Bio-Inspired Hierarchical Thin-Walled Structures

    Shaoqiang Xu1, Weiwei Li1,*, Lin Li2, Tao Li1, Chicheng Ma1

    CMES-Computer Modeling in Engineering & Sciences, Vol.131, No.2, pp. 929-947, 2022, DOI:10.32604/cmes.2022.018964

    Abstract Thin-walled structures have been used in many fields due to their superior mechanical properties. In this paper, two types of hierarchical multi-cell tubes, inspired by the self-similarity of Pinus sylvestris, are proposed to enhance structural energy absorption performance. The finite element models of the hierarchical structures are established to validate the crashworthiness performance under axial dynamic load. The theoretical model of the mean crushing force is also derived based on the simplified super folded element theory. The finite element results demonstrate that the energy absorption characteristics and deformation mode of the bionic hierarchical thin-walled tubes More >

  • Open Access

    ARTICLE

    Construction of Design Guidelines for Optimal Automotive Frame Shape Based on Statistical Approach and Mechanical Analysis

    Masanori Honda1,3, Chikara Kawamura1,3, Isamu Kizaki1, Yoichi Miyajima1, Akihiro Takezawa2,*, Mitsuru Kitamura3

    CMES-Computer Modeling in Engineering & Sciences, Vol.128, No.2, pp. 731-742, 2021, DOI:10.32604/cmes.2021.016181

    Abstract A body frame composed of thin sheet metal is a crucial structure that determines the safety performance of a vehicle. Designing a correct weight and high-performance automotive body is an emerging engineering problem. To improve the performance of the automotive frame, we attempt to reconstruct its design criteria based on statistical and mechanical approaches. At first, a fundamental study on the frame strength is conducted and a cross-sectional shape optimization problem is developed for designing the cross-sectional shape of an automobile frame having a very high mass efficiency for strength. Shape optimization is carried out… More >

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