Bingqian Ding1, Bei Cui1, Ming Gao, Zhenjiang Li, Chenyang Xu, Shaokang Fan, Weiya He
Oncology Research, Vol.25, No.3, pp. 331-340, 2017, DOI:10.3727/096504016X14736286083065
Abstract Ras-related protein 25 (Rab25) is a member of the Rab family, and it has been reported to play an important role
in tumorigenesis. However, its direct involvement in human glioblastoma multiforme (GBM) is still unclear. The
aim of the current study was to investigate the potential role of Rab25 in the growth, proliferation, invasion,
and migration of human GBM. Our results showed that Rab25 expression was significantly higher in human
GBM cell lines compared with a normal astrocyte cell line. In vitro functional studies revealed that knockdown
of Rab25 reduced cell proliferation and inhibited invasion More >
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