Yazhou Li*†, Yang Liu‡, Feiyu Shi†, Liang Cheng†, Junjun She†
Oncology Research, Vol.24, No.5, pp. 287-293, 2016, DOI:10.3727/096504016X14648701447779
Abstract Gastric cancer (GC) is the fourth most common malignancy and the second leading cause of cancer mortality around the world. However, the regulatory mechanisms of GC tumorigenesis and cancer cell motility are
completely unknown. We investigated the role of a RAS-related protein (Rap1b) in the progression of GC. Our
results showed that the expression of Rap1b is aberrantly upregulated in GC tissue samples and human GC cell
lines, and the high expression of Rap1b indicated a positive correlation with poor prognosis in patients with
GC. Inhibition of endogenous Rap1b dramatically reduced the cell cycle progression… More >
Login
Register
