Yun Ren^1,*, Lianzheng Zhao², Xiaofan Mo², Shuihua Zheng², Youdong Yang¹

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.7, pp. 1593-1609, 2024, DOI:10.32604/fdmp.2024.046274

Abstract A coupled Computational Fluid Dynamics-Discrete Element Method (CFD-DEM) approach is used to calculate the interaction of a flexible rag transported by a fluid current with a fixed solid cylinder. More specifically a hybrid Eulerian-Lagrangian approach is used with the rag being modeled as a set of interconnected particles. The influence of various parameters is considered, namely the inlet velocity (1.5, 2.0, and 2.5 m/s, respectively), the angle formed by the initially straight rag with the flow direction (45°, 60° and 90°, respectively), and the inlet position (90, 100, and 110 mm, respectively). The results show More > Graphic Abstract

Ivan Karpunin^*

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.6, pp. 1219-1232, 2024, DOI:10.32604/fdmp.2024.051062

Abstract The dynamics of a solid spherical body in an oscillating liquid flow in a vertical axisymmetric channel of variable cross section is experimentally studied. It is shown that the oscillating liquid leads to the generation of intense averaged flows in each of the channel segments. The intensity and direction of these flows depend on the dimensionless oscillating frequency. In the region of studied frequencies, the dynamics of the considered body is examined when the primary vortices emerging in the flow occupy the whole region in each segment. For a fixed frequency, an increase in the… More >

Tengfei Li¹, Wenhui Zhang¹, Ke Mi¹, Qingming Lin¹, Shuangwei Zhao^2,*, Jiayi Song²

Energy Engineering, Vol.121, No.7, pp. 1991-2007, 2024, DOI:10.32604/ee.2024.049460

Abstract Aiming at the problem of energy storage unit failure in the spring operating mechanism of low voltage circuit breakers (LVCBs). A fault diagnosis algorithm based on an improved Sparrow Search Algorithm (ISSA) optimized Backpropagation Neural Network (BPNN) is proposed to improve the operational safety of LVCB. Taking the 1.5kV/4000A/75kA LVCB as an example. According to the current operating characteristics of the energy storage motor, fault characteristics are extracted based on Empirical Wavelet Transform (EWT). Traditional BPNN has problems such as difficulty adjusting network weights and thresholds, being sensitive to initial weights, and quickly falling into More >

Jie Ma¹, Pengcheng Yue², Haozheng Yu¹, Yuqing Zhang³, Youwen Zhang¹, Cuiping Li³, Junhui Li^3,*, Wenwen Qin³, Yong Guo¹

Energy Engineering, Vol.121, No.7, pp. 1823-1846, 2024, DOI:10.32604/ee.2024.048225

Abstract In recent years, the proportion of installed wind power in the three north regions where wind power bases are concentrated is increasing, but the peak regulation capacity of the power grid in the three north regions of China is limited, resulting in insufficient local wind power consumption capacity. Therefore, this paper proposes a two-layer optimal scheduling strategy based on wind power consumption benefits to improve the power grid's wind power consumption capacity. The objective of the upper model is to minimize the peak-valley difference of the system load, which is mainly to optimize the system… More >

Pshtiwan Shakor^1,2,*, Nadarajah Gowripalan³, Paul Rocker⁴

Structural Durability & Health Monitoring, Vol.18, No.4, pp. 395-408, 2024, DOI:10.32604/sdhm.2024.049366

Abstract Self-compacting concrete (SCC) is the most flowable concrete type that exerts high pressure on formwork. SCC is the most commonly used concrete globally for construction applications due to its cost-effectiveness. However, to make a formwork resist the exerted lateral pressure of SCC, it is required to have a suitable design for formwork. This paper presents a novel approach on how could create and prepare the Fiber Bragg Grating (FBG) optics using as a sensor to measure lateral pressure and temperature of SCC. To ensure the FBG sensor works properly a validated methodology is conducted. In More > Graphic Abstract

Chengpeng Zhang, Junfeng Shi^*, Caiping Huang

Structural Durability & Health Monitoring, Vol.18, No.4, pp. 465-483, 2024, DOI:10.32604/sdhm.2024.048705

Abstract In this paper, an intelligent damage detection approach is proposed for steel-concrete composite beams based on deep learning and wavelet analysis. To demonstrate the feasibility of this approach, first, following the guidelines provided by relevant standards, steel-concrete composite beams are designed, and six different damage incidents are established. Second, a steel ball is used for free-fall excitation on the surface of the steel-concrete composite beams and a low-temperature-sensitive quasi-distributed long-gauge fiber Bragg grating (FBG) strain sensor is used to obtain the strain signals of the steel-concrete composite beams with different damage types. To reduce the… More >

Tao Xie^*, Yao Li^†, Shi-Lei Li^*, Hai-Feng Luo^‡

Oncology Research, Vol.24, No.6, pp. 447-453, 2016, DOI:10.3727/096504016X14685034103590

Abstract Although astragaloside IV exhibits anti-inflammation, immunoregulatory, and anticancer properties, the chemosensitization effects of astragaloside IV in colorectal cancer have never been reported. Our study tested whether astragaloside could increase cisplatin sensitivity in colorectal cancer. CCK-8 assay was used to measure the cell viability of colorectal cancer cells. Quantitative real-time PCR and Western blot were performed to determine the mRNA and protein expression, respectively. Our data revealed that astragaloside IV administration significantly suppressed the cell growth of colorectal cancer cells, whereas no obvious cytotoxicity of astragaloside IV was observed in nonmalignant colonic cells. In addition, combined… More >

Xinyang Liu^*1, Zhichao Wang^†1, Guoliang Zhang^‡1, Qikun Zhu^‡, Hui Zeng^‡, Tao Wang^‡, Feng Gao^‡, Zhan Qi^‡, Jinwen Zhang^§, Rui Wang^‡

Oncology Research, Vol.25, No.4, pp. 485-493, 2017, DOI:10.3727/096504016X14749340314441

Abstract Esophageal cancer is one of the most common types of cancer, and it has a poor prognosis. The molecular mechanisms of esophageal cancer progression remain largely unknown. In this study, we aimed to investigate the clinical significance and biological function of tumor necrosis factor receptor-associated factor 6 (TRAF6) in esophageal cancer. Expression of TRAF6 in esophageal cancer was examined, and its correlation with clinicopathological factors and patient prognosis was analyzed. A series of functional and mechanism assays were performed to further investigate the function and underlying mechanisms in esophageal cancer. Expression of TRAF6 was highly… More >

Cheng Xu^*1, Lu Cao^*1, Jianhua Liu^†1, Zhongrun Qian^‡, Yu Peng^§, Wenjing Zhu^§, Yongming Qiu^‡, Yingying Lin^‡¶

Oncology Research, Vol.25, No.3, pp. 407-415, 2017, DOI:10.3727/096504016X14743350548249

Abstract Elevated circulating asparaginyl endopeptidase (AEP), a novel lysosomal protease, has been found in breast cancer, and AEP is thus considered to be a prognostic factor in this disease. However, the pathological functions of circulating AEP in the development of breast cancer and the potential of AEP-targeted therapy remain unclear. We used MMTV-PyVmT transgenic mice, which spontaneously develop mammary tumors. Western blotting showed overexpression of AEP in both primary tumor tissue and lung metastases compared to their normal counterparts. Moreover, the concentration of circulating AEP gradually increased in the serum during the development of mammary tumors. More >

Shuye Lin^*†, Bonan Lin^*, Xiaoyue Wang^*, Yuanming Pan^‡, Qing Xu^*, Jin-Shen He^*, Wanghua Gong^§, Rui Xing^‡, Yuqi He^¶, Lihua Guo^*, Youyong Lu^‡, Ji Ming Wang^†, Jiaqiang Huang^*†

Oncology Research, Vol.25, No.3, pp. 317-329, 2017, DOI:10.3727/096504016X14734735156265

Abstract The ATPase H⁺/K⁺ Transporting Beta Subunit (ATP4B) encodes the b subunit of the gastric H⁺, K⁺ -ATPase, which controls gastric acid secretion and is therefore a target for acid reduction. Downregulation of ATP4B was recently observed in human gastric cancer (GC) without known mechanisms. In the present study, we demonstrated that ATP4B expression was decreased in human GC tissues and cell lines associated with DNA hypermethylation and histone hypoacetylation of histone H3 lysine 9 at its intragenic region close to the transcriptional start site. The expression of ATP4B was restored in GC cell lines by treatment with… More >