JOSé A. BOGA^1,2, ANA COTO-MONTES^2,3,*, RUSSEL J. REITER⁴

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.068245 - 23 January 2026

Abstract Aerobic glycolysis, also known as the Warburg effect, and the accumulation of lactate that it causes, are increasingly recognized outside the field of oncology as triggers of chronic non-neoplastic disorders. This review integrates preclinical and clinical evidence to evaluate the ability of melatonin to reverse Warburg-effect-like metabolic reprogramming. Literature on neurodegeneration, age-related sarcopenia, type 2 diabetes, chronic kidney disease, heart failure and pulmonary arterial hypertension (PAH) has been reviewed and synthesised. In all of these conditions, hypoxia-inducible factor 1α (HIF-1α) and pyruvate dehydrogenase kinase 4 (PDK4) inhibit the pyruvate dehydrogenase complex. This diverts pyruvate away… More >

Russel J. Reiter^1,*, Ramaswamy Sharma^2,*, Walter Manucha³, Walter Balduini⁴, Doris Loh⁵, Demetrios A. Spandidos⁶, Alejandro Romero⁷, Vasiliki E. Georgakopoulou⁸, Wei Zhu⁹

BIOCELL, Vol.49, No.11, pp. 2033-2067, 2025, DOI:10.32604/biocell.2025.067661 - 24 November 2025

Abstract The development of cancer cell resistance to conventional treatments continues to be a major obstacle in the successful treatment of tumors of many types. The discovery of a highly efficient direct and indirect free radical scavenger, melatonin, in the mitochondrial matrix may be a factor in determining both the occurrence of cancer cell drug insensitivity as well as radioresistance. This relates to two of the known hallmarks of cancer, i.e., exaggerated free radical generation in the mitochondria and the development of Warburg type metabolism (glycolysis). The hypothesis elaborated in this report assumes that the high… More >

Amine Batbat^1,2, Mohamed El Fadili³, Naoufal El Hachlafi^4,*, Amine Elbouzidi^5,*, Chaymae Hmimen⁶, Hiba Yahyaoui^2,7, Samir Jeddi⁶, Abdellatif Benbouazza², Kawtar Fikri-Benbrahim⁶, Mohamed Addi⁵, Samiah Hamad Al-Mijalli⁸, Khaoula Habbadi², Hassane Greche¹

Phyton-International Journal of Experimental Botany, Vol.94, No.2, pp. 481-501, 2025, DOI:10.32604/phyton.2025.059841 - 06 March 2025

Abstract This study highlights the regulatory potential antibacterial and antiradical of Origanum elongatum essential oil (EO), an endemic medicinal plant of Morocco used for its various properties. The chemical composition of the EO was characterized using gas chromatography-mass spectrometry (GC-MS). The antibacterial activity against different agricultural phytopathogens was determined by disc diffusion and microatmosphere methods, as well as by the determination of minimum inhibitory concentrations (MIC) and minimum bactericidal concentration (MBC), while the antioxidant activity was evaluated by DPPH and FRAP assays. To complement the experimental analyses, a molecular docking approach was used to predict and elucidate… More >

Snir Dekalo^1,2, Ohad Mazliah², Eyal Barkai^1,2, Yuval Bar-Yosef^1,2, Haim Herzberg^1,2, Tomer Bashi^1,2, Ibrahim Fahoum^2,3, Sophie Barnes^2,4, Mario Sofer^1,2, Ofer Yossepowitch^1,2, Gal Keren-Paz^1,2, Roy Mano^1,2

Canadian Journal of Urology, Vol.31, No.4, pp. 11955-11962, 2024

Abstract Introduction: Most men diagnosed with very-low and low-risk prostate cancer are candidates for active surveillance; however, there is still a misclassification risk. We examined whether PI-RADS category 4 or 5 combined with ISUP 1 on prostate biopsy predicts upgrading and/ or adverse pathology at radical prostatectomy.
Materials and methods: A total of 127 patients had ISUP 1 cancer on biopsy after multiparametric MRI (mpMRI) and then underwent radical prostatectomy. We then evaluated them for ISUP upgrading and/or adverse pathology on radical prostatectomy.
Results: Eight-nine patients (70%) were diagnosed with PI-RADS 4 or 5 lesions. ISUP upgrading was significantly… More >

Bárbara Vieira Lima Aguiar Melão¹, Sabrina Thalita dos Reis Faria², Kátia Ramos Moreira Leite², Ruan César Aparecido Pimenta², Miguel Srougi¹, Alberto Azoubel Antunes¹

Canadian Journal of Urology, Vol.31, No.4, pp. 11931-11940, 2024

Abstract Introduction: Prostate cancer has a variable natural history and, despite the existence of biochemical recurrence (BCR) predictors, they are still limited in predicting outcomes. The role of testosterone in advanced prostate cancer is well known, however its role in localized prostate cancer is still uncertain. In the present study, we evaluated the relationship of testosterone levels and androgen receptor (AR) expression with oncological and functional outcomes, in patients undergoing radical retropubic prostatectomy (RRP).
Materials and methods: Through a retrospective study, patients who underwent RRP, who had at least two preoperative total testosterone dosages, were analyzed and compared… More >

Matthew Buell, Brian Hu

Canadian Journal of Urology, Vol.31, No.5, pp. 12026-12029, 2024

Abstract Radical cystectomy is a preferred treatment for muscle invasive bladder cancer. Despite known complications, rapid onset, severe hyperkalemia necessitating abortion of surgery has not been reported. In this case report, a patient with end stage renal disease (ESRD) undergoing attempted cystectomy developed severe intraoperative hyperkalemia and acidosis that led to abortion of surgery and transfer to the medical intensive care unit for emergent hemodialysis. The multifactorial etiology was related to respiratory acidosis, ESRD, patient positioning, clipping of ureters, and body habitus, as well as an idiopathic element. Knowledge of hyperkalemia etiologies can assist in diagnosis More >

Xujing Zhang¹, Hatem Abushammala², Debora Puglia³, Binbao Lu¹, Pengwu Xu¹, Weijun Yang^1,*, Piming Ma¹

Journal of Renewable Materials, Vol.12, No.5, pp. 895-908, 2024, DOI:10.32604/jrm.2024.049810 - 17 July 2024

Abstract Fluorescent nanomaterials have attracted much attention, due to their unique luminescent properties and promising applications in biomedical areas. In this study, lignin based fluorescent nanoparticles (LFNP) with high yield (up to 32.4%) were prepared from lignin nanoparticles (LNP) by one-pot hydrothermal method with ethylenediamine (EDA) and citric acid. Morphology and chemical structure of LFNP were investigated by SEM, FT-IR, and zeta potential, and it was found that the structure of LFNP changed with the increase of citric acid addition. LFNP showed the highest fluorescence intensity under UV excitation at wavelengths of 375–385 nm, with emission More > Graphic Abstract

Adel Arezki^1,*, Iman Sadri^1,*, Ahmed S. Zakaria², Felix Couture³, David-Dan Nguyen⁴, Pierre Karakiewicz⁵, Dean S. Elterman⁶, Kevin C. Zorn²

Canadian Journal of Urology, Vol.30, No.1, pp. 11424-11431, 2023

Abstract Introduction: This study aims to report age-stratified potency outcomes in men undergoing robot-assisted radical prostatectomy (RARP).
Materials and methods: A retrospective review was performed on a database of 1737 patients who underwent RARP for localized prostate cancer between 2007 and 2019. Inclusion criteria consisted of patients undergoing bilateral nerve-sparing RARP. Exclusion criteria were preoperative Sexual Health Inventory for Men (SHIM) score < 17 and postoperative androgen deprivation therapy or radiotherapy. Patients were divided into four cohorts based on age: ≤ 54 years (group 1); 55-59 years (group 2); 60-64 years (group 3) and ≥ 65 years (group… More >

Arjun Pon Avudaiappan¹, Pushan Prabhakar¹, Hariharan Ganapathi², Nathan VanderVeer-Harris³, Jorge Caso^1,3, Rohan Garje¹, Murugesan Manoharan^1,3

Canadian Journal of Urology, Vol.30, No.5, pp. 11686-11691, 2023

Abstract Introduction: Radical cystectomy (RC) is an effective curative treatment option for muscle-invasive bladder cancer (MIBC). However, chemoradiation (CRT) is an evolving bladder preservation protocol alternative to RC. With the increase in life expectancy, it is essential to understand the survival outcomes among octogenarians treated with RC and CRT. In this study, we use the National Cancer Database (NCDB) to compare the survival outcomes between RC and CRT in octogenarians.
Materials and methods: We collected the data of patients treated for bladder cancer between 2004 to 2018 from the NCDB. Our primary analytic cohort included patients with MIBC… More >

YINGHUA LUO^1,#, YU ZHANG^2,#, TONG ZHANG^2,#, YANNAN LI², HUI XUE², JINGLONG CAO², WENSHUANG HOU², JIAN LIU², YUHE CUI², TING XU², CHENGHAO JIN^2,3,*

BIOCELL, Vol.47, No.5, pp. 965-975, 2023, DOI:10.32604/biocell.2023.027729 - 10 April 2023

Abstract Marine collagen peptides (MCPs) are natural products prepared by hydrolyzing marine collagen protein through a variety of chemical methods or enzymes. MCPs have a range of structures and biological activities and are widely present in marine species. MCPs also have a small molecular weight, are easily modified, and absorbed by the body. These properties have attracted great interest from researchers studying antioxidant, anti-tumor, and anti-aging activities. MCPs of specific molecular weights have significant anti-tumor activity and no toxic side effects. Thus, MCPs have the potential use as anti-cancer adjuvant drugs. Free radicals produced by oxidation More >