Huijie Fan^*1, Jing Li^*1, Yongxu Jia^*, Jingjing Wu^*, Long Yuan^†, Mingjun Li^*, Jiangqi Wei^‡, Benling Xu^§

Oncology Research, Vol.25, No.7, pp. 1061-1068, 2017, DOI:10.3727/096504016X14830466773541

Abstract Ribosomal protein L34 (RPL34) belongs to the L34E family of ribosomal proteins and contains a zinc finger motif. Aberrant expression of RPL34 has been reported in several human malignancies. However, the precise role and potential underlying mechanisms of RPL34 in human esophageal cancer remain largely unknown. Thus, the objective of this study was to investigate the role of RPL34 in esophageal cancer progression. Our results showed that the expression of RPL34 at both the mRNA and protein levels was frequently upregulated in esophageal cancer cell lines. Knockdown of RPL34 efficiently inhibited esophageal cancer cell proliferation, More >

MAHER KURDI^1,*, ALAA ALKHOTANI², ABDULRAHMAN SABBAGH³, EYAD FAIZO⁴, AHMED I. LARY⁵, AHMED K. BAMAGA⁶, MAJID ALMANSOURI⁷, BADR HAFIZ⁸, THAMER ALSHARIF⁹, SALEH BAEESA⁸

Oncology Research, Vol.32, No.6, pp. 1037-1045, 2024, DOI:10.32604/or.2024.051112

Abstract Background: The dysregulation of Isocitrate dehydrogenase (IDH) and the subsequent production of 2-Hydroxyglutrate (2HG) may alter the expression of epigenetic proteins in Grade 4 astrocytoma. The interplay mechanism between IDH, O-6-methylguanine-DNA methyltransferase (MGMT)-promoter methylation, and protein methyltransferase proteins-5 (PRMT5) activity, with tumor progression has never been described. Methods: A retrospective cohort of 34 patients with G4 astrocytoma is classified into IDH-mutant and IDH-wildtype tumors. Both groups were tested for MGMT-promoter methylation and PRMT5 through methylation-specific and gene expression PCR analysis. Inter-cohort statistical significance was evaluated. Results: Both IDH-mutant WHO grade 4 astrocytomas (n = 22, 64.7%) and IDH-wildtype… More > Graphic Abstract

Amal Hkiri^1,*, Hamzah Faraj², Omar Ben Bahri², Mouna Karmani¹, Sami Alqurashi², Mohsen Machhout¹

CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 1835-1854, 2024, DOI:10.32604/cmc.2024.049207

Abstract The Internet of Things (IoT) has witnessed a significant surge in adoption, particularly through the utilization of Wireless Sensor Networks (WSNs), which comprise small internet-connected devices. These deployments span various environments and offer a multitude of benefits. However, the widespread use of battery-powered devices introduces challenges due to their limited hardware resources and communication capabilities. In response to this, the Internet Engineering Task Force (IETF) has developed the IPv6 Routing Protocol for Low-power and Lossy Networks (RPL) to address the unique requirements of such networks. Recognizing the critical role of RPL in maintaining high performance,… More >

Amal Hkiri^1,*, Mouna Karmani¹, Omar Ben Bahri², Ahmed Mohammed Murayr², Fawaz Hassan Alasmari², Mohsen Machhout¹

CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 227-247, 2024, DOI:10.32604/cmc.2023.047087

Abstract The RPL (IPv6 Routing Protocol for Low-Power and Lossy Networks) protocol is essential for efficient communication within the Internet of Things (IoT) ecosystem. Despite its significance, RPL’s susceptibility to attacks remains a concern. This paper presents a comprehensive simulation-based analysis of the RPL protocol’s vulnerability to the decreased rank attack in both static and mobile network environments. We employ the Random Direction Mobility Model (RDM) for mobile scenarios within the Cooja simulator. Our systematic evaluation focuses on critical performance metrics, including Packet Delivery Ratio (PDR), Average End to End Delay (AE2ED), throughput, Expected Transmission Count More >

Yanshan Lu¹, Binbin He¹, Jun Jiang¹, Ruixiao Lin^2,*, Xinzhen Zhang², Zaimin Yang³, Zhi Rao³, Wenchuan Meng³, Siyang Sun³

Energy Engineering, Vol.120, No.12, pp. 2803-2818, 2023, DOI:10.32604/ee.2023.042328

Abstract To solve the problem of residual wind power in offshore wind farms, a hydrogen production system with a reasonable capacity was configured to enhance the local load of wind farms and promote the local consumption of residual wind power. By studying the mathematical model of wind power output and calculating surplus wind power, as well as considering the hydrogen production/storage characteristics of the electrolyzer and hydrogen storage tank, an innovative capacity optimization allocation model was established. The objective of the model was to achieve the lowest total net present value over the entire life cycle.… More >

VIBHAV VARSHNEY^1,*, PRASHANT SINGH KUSHWAH², NEETU AGRAWAL¹, AHSAS GOYAL^1,*, GOVIND SINGH²

BIOCELL, Vol.47, No.10, pp. 2141-2149, 2023, DOI:10.32604/biocell.2023.030853

Abstract The persistent global pandemic, COVID-19, stems from the pathogenic influence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), yielding an unprecedented worldwide crisis. With reference to a WHO report, the count of COVID-19 cases had exceeded 754 million by February 03, 2023. Intriguingly, emerging research has spotlighted the intricate interplay of gut microbiota and mitochondrial entities, acting as potent immunomodulatory factors at the cellular and molecular levels. This interconnection operates through a series of dynamic mechanisms. SARS-CoV-2 infection perturbs the delicate equilibrium of gut microbiota, leading to dysbiosis—a signature biomarker. This imbalance is intrinsically linked More >

Shadi Al-Sarawi¹, Mohammed Anbar^1,*, Basim Ahmad Alabsi², Mohammad Adnan Aladaileh³, Shaza Dawood Ahmed Rihan²

CMC-Computers, Materials & Continua, Vol.77, No.1, pp. 491-515, 2023, DOI:10.32604/cmc.2023.041108

Abstract The Internet of Things (IoT) consists of interconnected smart devices communicating and collecting data. The Routing Protocol for Low-Power and Lossy Networks (RPL) is the standard protocol for Internet Protocol Version 6 (IPv6) in the IoT. However, RPL is vulnerable to various attacks, including the sinkhole attack, which disrupts the network by manipulating routing information. This paper proposes the Unweighted Voting Method (UVM) for sinkhole node identification, utilizing three key behavioral indicators: DODAG Information Object (DIO) Transaction Frequency, Rank Harmony, and Power Consumption. These indicators have been carefully selected based on their contribution to sinkhole… More >

Muhammad Ali Khan¹, Rao Naveed Bin Rais^2,*, Osman Khalid¹

CMC-Computers, Materials & Continua, Vol.77, No.1, pp. 827-843, 2023, DOI:10.32604/cmc.2023.040756

Abstract The Internet of Things (IoT) comprises numerous resource-constrained devices that generate large volumes of data. The inherent vulnerabilities in IoT infrastructure, such as easily spoofed IP and MAC addresses, pose significant security challenges. Traditional routing protocols designed for wired or wireless networks may not be suitable for IoT networks due to their limitations. Therefore, the Routing Protocol for Low-Power and Lossy Networks (RPL) is widely used in IoT systems. However, the built-in security mechanism of RPL is inadequate in defending against sophisticated routing attacks, including Sybil attacks. To address these issues, this paper proposes a… More >

NAN TANG^1,#, YAJING ZHAN^1,#, JIAYAN MAO^2,#, ANKANG YIN¹, WEI WANG^3,*, JUAN WANG^3,*

BIOCELL, Vol.47, No.9, pp. 2009-2026, 2023, DOI:10.32604/biocell.2023.029269

Abstract Non-small cell lung cancer (NSCLC) is a malignant tumor with high incidence worldwide. Triptolide (TP), extracted from Tripterygium wilfordii Hook F, exhibits potent broad-spectrum antitumor activity. Although some mechanisms through which TP inhibits NSCLC are well understood, those that involve ribosomal proteins remain yet to be understood. In this study, the transcriptome and proteome were integrated and analyzed. Our data indicated ribosomal protein L4 (RPL4) to be a core hub protein in the protein-protein interaction network. RPL4 is overexpressed in NSCLC tissues and cells. Transfection with siRPL4 or TP treatment alone arrested the cell cycle in More > Graphic Abstract

Guangfei Jia^*, Fengwei Guo, Zhe Wu, Suxiao Cui, Jiajun Yang

Structural Durability & Health Monitoring, Vol.17, No.5, pp. 383-405, 2023, DOI:10.32604/sdhm.2023.026885

Abstract With the development of multi-signal monitoring technology, the research on multiple signal analysis and processing has become a hot subject. Mechanical equipment often works under variable working conditions, and the acquired vibration signals are often non-stationary and nonlinear, which are difficult to be processed by traditional analysis methods. In order to solve the noise reduction problem of multiple signals under variable speed, a COT-DCS method combining the Computed Order Tracking (COT) based on Chirplet Path Pursuit (CPP) and Distributed Compressed Sensing (DCS) is proposed. Firstly, the instantaneous frequency (IF) is extracted by CPP, and the… More > Graphic Abstract