Mayuri Shukla¹, Soraya Boonmag², Parichart Boontem¹, Piyarat Govitrapong^1,*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.072557 - 23 January 2026

Abstract Ischemic stroke is one of the major causes of long-term disability and mortality worldwide. It results from an interruption in the cerebral blood flow, triggering a cascade of detrimental events like oxidative stress, mitochondrial dysfunction, neuroinflammation, excitotoxicity, and apoptosis, causing neuronal injury and cellular death. Melatonin, a pleiotropic indoleamine produced by the pineal gland, has multifaceted neuroprotective effects on stroke pathophysiology. Interestingly, the serum melatonin levels are associated with peroxidation and antioxidant status, along with mortality score in patients with severe middle cerebral artery infarction. Melatonin exhibits strong antioxidant, anti-inflammatory, and anti-apoptotic properties and preserves More >

Shail Rakesh Modi, Terrick Andey^*, George Acquaah-Mensah^*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.070793 - 19 January 2026

Abstract Objectives: The current treatment options and therapeutic targets for triple-negative breast cancer (TNBC), an aggressive subtype of breast cancer (BrCA), are limited. This study aimed to identify novel biomarkers and transcriptional regulatory networks (TRN) inherent in TNBC samples. Methods: We analyzed pan-cancer BrCA datasets from The Cancer Genome Atlas (TCGA) to compare triple-positive breast cancer (TPBC) with TNBC. TRN algorithms and virtual inference of protein-enriched regulon (VIPER) were used to identify master regulators and their target genes. Utilizing TNBC cells (MDA-MB-231 and MDA-MB-468), we validated the relationship of nuclear factor erythroid 2-like 3 (NFE2L3) and… More > Graphic Abstract

Mustansar Mubeen¹, Yasir Iftikhar^1,*, Ganesan Vadamalai^2,3, Muhammad Aasim⁴, Muhammad Faiq⁵, Uthman Balgith Algopishi⁶, Ahmed Ezzat Ahmed^6,7

Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 3827-3843, 2025, DOI:10.32604/phyton.2025.071555 - 29 December 2025

Abstract Citrus viroids are small non-coding RNA pathogens that pose a significant threat to global citrus production by reducing fruit yield, quality, and tree longevity. Several viroids, including Citrus exocortis viroid (CEVd), Hop stunt viroid (HSVd), Citrus bent leaf viroid (CBLVd), and newly identified members such as Citrus Viroid VI (CVd-VI) and Citrus Viroid VII (CVd-VII) have been reported from diverse citrus-growing regions. These pathogens are transmitted mainly through vegetative propagation, contaminated tools, and occasionally via seed or pollen, making their management complex. This review synthesizes current knowledge on the biology, structural diversity, transmission, symptomatology, detection,… More >

Vinay Durbhakula^1,*, Ziv Savin¹, Einat Savin-Shalom², Stephanie L. Gold², Kavita Gupta¹, Eve Frangopoulos¹, Blair Gallante¹, William M. Atallah¹, Mantu Gupta¹

Canadian Journal of Urology, Vol.32, No.6, pp. 659-668, 2025, DOI:10.32604/cju.2025.067614 - 30 December 2025

Abstract Background: A well-established correlation exists between Inflammatory Bowel Disease (IBD) and urolithiasis. However, the influence of surgical history on the severity of urolithiasis in IBD patients remains underexplored. This study aims to investigate the association between gastrointestinal (GI) bowel resection and urolithiasis severity in patients with IBD. Methods: This retrospective cohort study analyzed 42 patients diagnosed with both IBD and urolithiasis between 2016 and 2024. Patients were categorized based on their history of bowel resection. Primary outcomes included maximal stone burden, need for urolithiasis surgery, and stone recurrence. Secondary outcomes were stone-related clinical events, multiple… More >

Mostafa Mohamed Ahmed Mohamed Alsaedy^1,*, Atef Zaki Ghalwash¹, Aliaa Abd Elhalim Yousif², Safaa Magdy Azzam¹

Journal of Cyber Security, Vol.7, pp. 653-674, 2025, DOI:10.32604/jcs.2025.073547 - 24 December 2025

Abstract Mobile financial applications and payment systems face significant security challenges from reverse engineering attacks. Attackers can decompile Android Package Kit (APK) files, modify permissions, and repackage applications with malicious capabilities. This work introduces E-AAPIV (Enhanced Android Apps Permissions Integrity Verifier), an advanced framework that uses Merkle Tree technology for real-time manifest integrity verification. The proposed system constructs cryptographic Merkle Tree from AndroidManifest.xml permission structures. It establishes secure client-server connections using Elliptic Curve Diffie-Hellman Protocol (ECDH-P384) key exchange. Root hashes are encrypted with Advanced Encryption Standard-256-Galois/Counter Mode (AES-256-GCM), integrated with hardware-backed Android Keystore for enhanced security. More >

Yan Gui^1,#, Wen Pan^1,#, Ziyi Dong^1,#, Dongzhi Hu^1,#, Yaoyang Guo¹, Xinyi Wen¹, Haiyang Zhang², Zhansheng Jiang^1,*, Xiangqian Zheng^1,*, Ming Gao^2,*, Junyi Wang^1,*

Oncology Research, Vol.33, No.12, pp. 3991-4011, 2025, DOI:10.32604/or.2025.067182 - 27 November 2025

Abstract Objectives: Metastatic spread to the lung is one of the leading causes of fatal outcomes in thyroid cancer, but the underlying molecular mechanisms remain unclear. To investigate how exosomal microRNA-17-5p (miR-17-5p) promotes lung metastasis in thyroid cancer within the framework of the “seed and soil” hypothesis. Methods: Serum exosomes from thyroid cancer lung metastasis patients and controls were analyzed for miR-17, which was elevated in metastatic cases. miR-17 was transfected into embryonic lung fibroblasts (MRC-5), and their supernatants were co-cultured with thyroid cancer cells (Cal62). Cell proliferation and migration were evaluated using colony formation, Ki67… More >

Sidra Naseem¹, Rashid Jahangir^1,*, Nazik Alturki², Faheem Shehzad³, Muhammad Sami Ullah⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.2, pp. 2481-2501, 2025, DOI:10.32604/cmes.2025.072575 - 26 November 2025

Abstract Diagnosing gastrointestinal tract diseases is a critical task requiring accurate and efficient methodologies. While deep learning models have significantly advanced medical image analysis, challenges such as imbalanced datasets and redundant features persist. This study proposes a novel framework that customizes two deep learning models, NasNetMobile and ResNet50, by incorporating bottleneck architectures, named as NasNeck and ResNeck, to enhance feature extraction. The feature vectors are fused into a combined vector, which is further optimized using an improved Whale Optimization Algorithm to minimize redundancy and improve discriminative power. The optimized feature vector is then classified using artificial… More >

Huihui Yang¹, Saif Ur Rehman Khan^2,*, Omair Bilal², Chao Chen^1,*, Ming Zhao²

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.2, pp. 2401-2434, 2025, DOI:10.32604/cmes.2025.072148 - 26 November 2025

Abstract Detecting Alzheimer’s disease is essential for patient care, as an accurate diagnosis influences treatment options. Classifying dementia from non-dementia in brain MRIs is challenging due to features such as hippocampal atrophy, while manual diagnosis is susceptible to error. Optimal computer-aided diagnosis (CAD) systems are essential for improving accuracy and reducing misclassification risks. This study proposes an optimized ensemble method (CEOE-Net) that initiates with the selection of pre-trained models, including DenseNet121, ResNet50V2, and ResNet152V2 for unique feature extraction. Each selected model is enhanced with the inclusion of a channel attention (CA) block to improve the feature… More >

Sadia Fatima¹, Fadl Dahan^2,*, Jamal Hussain Shah¹, Refan Almohamedh², Mohammed Aloqaily², Samia Riaz¹

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.1, pp. 971-994, 2025, DOI:10.32604/cmes.2025.070272 - 30 October 2025

Abstract The human gastrointestinal (GI) tract is influenced by numerous disorders. If not detected in the early stages, they may result in severe consequences such as organ failure or the development of cancer, and in extreme cases, become life-threatening. Endoscopy is a specialised imaging technique used to examine the GI tract. However, physicians might neglect certain irregular morphologies during the examination due to continuous monitoring of the video recording. Recent advancements in artificial intelligence have led to the development of high-performance AI-based systems, which are optimal for computer-assisted diagnosis. Due to numerous limitations in endoscopic image… More >

Chiao-Ping Chen^1,2, Yan-Jei Tang^1,2, You-Yan Cai¹, Yi-Ru Pan³, Chun-Nan Yeh^3,4, Wen-Kuan Huang^1,2, Chih-Hong Lo^1,2, Yu-Tien Hsiao^1,2, Hsuan-Jen Shih^1,*, Chiao-En Wu^1,2,4,5,*

Oncology Research, Vol.33, No.11, pp. 3429-3446, 2025, DOI:10.32604/or.2025.066672 - 22 October 2025

Abstract Background: KIT proto-oncogene, receptor tyrosine kinase (KIT, CD117) and platelet-derived growth factor-alpha (PDGFRA) are key drivers of gastrointestinal stromal tumors (GIST), but resistance to targeted therapy often arises from tumor protein p53 (p53) alterations and loss of cell cycle control. However, the role of p53 status in GIST therapeutic potential has rarely been studied, so this study aimed to employ both wild-type and mutant p53 GIST models to investigate how p53 dysfunction influences the efficacy of p53 pathway-targeted therapies. Methods: The efficacy of the mouse double minute 2 homolog (MDM2) inhibitor (HDM201) and the Wee1… More >