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  • Open Access

    ARTICLE

    Salicylic Acid-Elicited Alkaloid Accumulation in Pinellia ternata Microtubers: Cytotoxicity and Transcriptomic Analysis

    Xiaoqing Jiang1,2,#, Pengchong Li1,2,#, Hongchuang Liu1,2, Wenjie Dong1,2, Wenjing Liu1,2, Di Wu1,2, Jianping Xue1,2, Fenglan Zhao1,2,*, Yongbo Duan1,2,*

    Phyton-International Journal of Experimental Botany, Vol.95, No.1, 2026, DOI:10.32604/phyton.2026.074434 - 30 January 2026

    Abstract As its tuberous alkaloids induce valuable pharmacological effects, Pinellia ternata has considerable clinical value. However, its production currently fails to meet its demand. In vitro microtuber culture, combined with salicylic acid (SA) elicitation, may provide an effective alternative to traditional field production. In this study, an in vitro P. ternata microtuber induction system was developed and used to evaluate SA-induced elicitation of alkaloid accumulation. The quality of in vitro microtubers was assessed by total alkaloid measurement, a cytotoxicity assay, and transcriptomic analysis. With or without SA treatment, P. ternata microtuber induction was achieved within 60 d using petiole-derived explants, with… More >

  • Open Access

    ARTICLE

    Tissue-Specific Transcriptomic Responses and Viral Accumulation in Lily Cultivars Infected with Cucumber Mosaic Virus

    Yun-Im Kang1, Youn Jung Choi1, Su Young Lee1, Young-Ran Lee1, Ki-Byung Lim2,3, Yun-Jae Ahn2,3,*

    Phyton-International Journal of Experimental Botany, Vol.95, No.1, 2026, DOI:10.32604/phyton.2026.073138 - 30 January 2026

    Abstract Cucumber mosaic virus (CMV) threatens lily production by reducing floral quality and enabling carry-over via infected planting stock. To explore tissue-specific host responses, we analyzed a legacy, single-replicate RNA-seq dataset from two cultivars, ‘Cancun’ and ‘Connecticut King’ (CK), profiling leaf (source) and bulb (sink) tissues at 0 and 28 days post-inoculation (dpi), alongside leaf DAS-ELISA. Principal component analysis indicated that tissue identity dominated the transcriptome (PC1 = 47.7%), with CMV treatment driving within-tissue shifts over time. Exploratory Gene Ontology/KEGG summaries and a focused marker panel revealed a consistent split: in leaves, genes linked to jasmonate/WRKY-associated… More >

  • Open Access

    ARTICLE

    Novel Analysis of SiO2 + ZnO + MWCNT-Ternary Hybrid Nanofluid Flow in Electromagnetic Squeezing Systems

    Muhammad Hamzah1, Muhammad Ramzan2,*, Abdulrahman A. Almehizia3, Ibrahim Mahariq4,5,6,7,8,*, Laila A. Al-Essa9, Ahmed S. Hassan10

    CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.1, 2026, DOI:10.32604/cmes.2025.070435 - 29 January 2026

    Abstract The present investigation inspects the unsteady, incompressible MHD-induced flow of a ternary hybrid nanofluid made of SiO2 (silicon dioxide), ZnO (zinc oxide), and MWCNT (multi-walled carbon nanotubes) suspended in a water-ethylene glycol base fluid between two perforated squeezing Riga plates. This problem is important because it helps us understand the complicated connections between magnetic fields, nanofluid dynamics, and heat transport, all of which are critical for designing thermal management systems. These findings are especially useful for improving the design of innovative cooling technologies in electronics, energy systems, and healthcare applications. No prior study has… More >

  • Open Access

    ARTICLE

    Evaluation of Strip-Processed Cotton Stalks as a Raw Material for Structural Panels

    Aadarsha Lamichhane1, Arun Kuttoor Vasudevan1, Ethan Dean1, Mostafa Mohammadabadi1,*, Kevin Ragon1, Ardeshir Adeli2

    Journal of Renewable Materials, Vol.14, No.1, 2026, DOI:10.32604/jrm.2025.02025-0146 - 23 January 2026

    Abstract This study explores a novel method for processing cotton stalks—an abundant agricultural byproduct—into long strips that serve as sustainable raw material for engineered bio-based panels. To evaluate the effect of raw material morphology on panel’s performance, two types of cotton stalk-based panels were developed: one using long strips, maintaining fiber continuity, and the other using ground particles, representing conventional processing. A wood strand-based panel made from commercial southern yellow pine strands served as the control. All panels were bonded using phenol-formaldehyde resin and hot-pressed to a target thickness of 12.7 mm and density of 640 kg/m3.… More >

  • Open Access

    ARTICLE

    Integrative Analysis of scRNA-Seq and Bulk RNA-Seq Reveals Novel Transcription Factor Regulating Endothelial Heterogeneity Induced by Lrg1 Following Cerebral Ischemia-Reperfusion

    SHAOFENG XIONG1,2, WENKAI LV3, GUOSHENG CAO4, LONGSHENG FU1, WEN LIU3, MENGFAN LEI2, YANNI LV1,5,*

    BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.073401 - 23 January 2026

    Abstract Objective: Leucine-rich alpha-2 glycoprotein 1 (Lrg1) could regulate diverse cells in cerebral ischemia-reperfusion. Our study seeks to uncover Lrg1’s impact on endothelial cell heterogeneity via differentiation pathways and transcription factors. Method: The CSOmap model measured cell-to-brain-center distances using single-cell RNA sequencing (scRNA-seq) data in middle cerebral artery occlusion reperfusion (MCAO/R). Monocle2 mapped endothelial differentiation paths. Gene set enrichment analysis (GSEA) analyzed endothelial subcluster variations. Database searches revealed a zinc finger MIZ-type containing 1 protein-frizzled 3 (Zmiz1-Fzd3) promoter interaction. Endothelial cells were transfected with a Fzd3 promoter-luciferase plasmid. Polymerase chain reaction (PCR) and western blotting assessed… More >

  • Open Access

    ARTICLE

    Development and Assessment of a Novel Palmitoylation-Related lncRNA Signature for Prognosis and Immune Landscape in Hepatocellular Carcinoma

    Zhilong He1,#, Jing Qin1,#, Sixuan Wu2,#, Xian Liang1, Yu Liu1, Jinfeng Qiu1, Zhimin Li2,*, Kai Hu1,*

    Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.070567 - 19 January 2026

    Abstract Objective: The contribution of long non-coding RNAs (lncRNAs) associated with protein palmitoylation to the progression of hepatocellular carcinoma (HCC) remains largely unclear. This study sought to establish a prognostic signature based on palmitoylation-related lncRNAs and explore their functional implications in HCC. Methods: RNA sequencing and clinical data for HCC and normal tissues were sourced from the Cancer Genome Atlas (TCGA). Pearson correlation analysis was used to identify lncRNAs that were co-expressed with palmitoylation-related genes. Univariate Cox regression was applied to select lncRNAs with prognostic value, followed by the construction of a predictive model using the… More >

  • Open Access

    RETRACTION

    Retraction: MicroRNA-148a Acts as a Tumor Suppressor in Osteosarcoma via Targeting Rho-Associated Coiled-Coil Kinase

    Oncology Research Editorial Office

    Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.077270 - 30 December 2025

    Abstract This article has no abstract. More >

  • Open Access

    RETRACTION

    Retraction: MicroRNA-133b Inhibits Proliferation, Cellular Migration, and Invasion via Targeting LASP1 in Hepatocarcinoma Cells

    Oncology Research Editorial Office

    Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.077269 - 30 December 2025

    Abstract This article has no abstract. More >

  • Open Access

    REVIEW

    RP11-Derived Long Non-Coding RNAs in Hepatocellular Carcinoma: Hidden Treasures in Plain Sight

    Se Ha Jang1,2,#, Hyung Seok Kim3,#, Jung Woo Eun1,*

    Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.072240 - 30 December 2025

    Abstract Hepatocellular carcinoma (HCC) remains one of the most prevalent and lethal malignancies worldwide. Long non-coding RNAs (lncRNAs) have emerged as crucial regulators of gene expression and cancer progression, yet the functional diversity of RP11-derived lncRNAs—originally mapped to bacterial artificial chromosome (BAC) clones from the Roswell Park Cancer Institute—has only recently begun to be appreciated. This mini-review aims to systematically synthesize current findings on RP11-derived lncRNAs in HCC, outlining their genomic origins, molecular mechanisms, and biological significance. We highlight their roles in metabolic reprogramming, microRNA network modulation, and tumor progression, as well as their diagnostic and More >

  • Open Access

    ARTICLE

    Hybrid AI-IoT Framework with Digital Twin Integration for Predictive Urban Infrastructure Management in Smart Cities

    Abdullah Alourani1, Mehtab Alam2,*, Ashraf Ali3, Ihtiram Raza Khan4, Chandra Kanta Samal2

    CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-32, 2026, DOI:10.32604/cmc.2025.070161 - 10 November 2025

    Abstract The evolution of cities into digitally managed environments requires computational systems that can operate in real time while supporting predictive and adaptive infrastructure management. Earlier approaches have often advanced one dimension—such as Internet of Things (IoT)-based data acquisition, Artificial Intelligence (AI)-driven analytics, or digital twin visualization—without fully integrating these strands into a single operational loop. As a result, many existing solutions encounter bottlenecks in responsiveness, interoperability, and scalability, while also leaving concerns about data privacy unresolved. This research introduces a hybrid AI–IoT–Digital Twin framework that combines continuous sensing, distributed intelligence, and simulation-based decision support. The… More >

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