Nurlan Zhangabay^1,*, Ulzhan Ibraimova², Marco Bonopera^3,*, Ulanbator Suleimenov¹, Konstantin Avramov⁴, Maryna Chernobryvko⁴, Aigerim Yessengali¹

Structural Durability & Health Monitoring, Vol.19, No.1, pp. 1-23, 2025, DOI:10.32604/sdhm.2024.053391 - 15 November 2024

Abstract Using the software ANSYS-19.2/Explicit Dynamics, this study performed finite-element modeling of the large-diameter steel pipeline cross-section for the Beineu-Bozoy-Shymkent gas pipeline with a non-through straight crack, strengthened by steel wire wrapping. The effects of the thread tensile force of the steel winding in the form of single rings at the crack edges and the wires with different winding diameters and pitches were also studied. The results showed that the strengthening was preferably executed at a minimum value of the thread tensile force, which was 6.4% more effective than that at its maximum value. The analysis… More >

Ting Chen¹, Shuna Jiang², Xin Fan^3,*, Jianchuan Xia², Xiujuan Zhang², Chuanwen Luo³, Yi Hong³

CMC-Computers, Materials & Continua, Vol.81, No.2, pp. 2195-2217, 2024, DOI:10.32604/cmc.2024.056960 - 18 November 2024

Abstract In blockchain-based unmanned aerial vehicle (UAV) communication systems, the length of a block affects the performance of the blockchain. The transmission performance of blocks in the form of finite character segments is also affected by the block length. Therefore, it is crucial to balance the transmission performance and blockchain performance of blockchain communication systems, especially in wireless environments involving UAVs. This paper investigates a secure transmission scheme for blocks in blockchain-based UAV communication systems to prevent the information contained in blocks from being completely eavesdropped during transmission. In our scheme, using a friendly jamming UAV… More >

Van-Truong Nguyen^1,*, Dai-Nhan Duong¹, Dinh-Hieu Phan¹, Thanh-Lam Bui¹, Xiem HoangVan², Phan Xuan Tan³

CMC-Computers, Materials & Continua, Vol.81, No.2, pp. 2337-2356, 2024, DOI:10.32604/cmc.2024.055412 - 18 November 2024

Abstract This paper proposes an adaptive nonlinear proportional-derivative (ANPD) controller for a two-wheeled self-balancing robot (TWSB) modeled by the Lagrange equation with external forces. The proposed control scheme is designed based on the combination of a nonlinear proportional-derivative (NPD) controller and a genetic algorithm, in which the proportional-derivative (PD) parameters are updated online based on the tracking error and the preset error threshold. In addition, the genetic algorithm is employed to adaptively select initial controller parameters, contributing to system stability and improved control accuracy. The proposed controller is basic in design yet simple to implement. The… More >

MAHDI ABDOLI SHADBAD¹, BEHZAD BARADARAN^2,*

Oncology Research, Vol.32, No.12, pp. 1949-1958, 2024, DOI:10.32604/or.2024.051569 - 13 November 2024

Abstract Background: Glioblastoma remains a highly invasive primary brain malignancy with an undesirable prognosis. Growing evidence has shed light on the importance of microRNAs (miRs), as small non-coding RNAs, in tumor development and progression. The present study leverages the in-silico and in-vitro techniques to investigate the significance of hsa-miR-181a-5p and the underlying hsa-miR-181a-5p-meidated signaling pathway in glioblastoma development. Methods: Bioinformatic studies were performed on GSE158284, GSE108474 (REMBRANDT study), TCGA-GTEx, CCLE, GeneMANIA, Reactome, WikiPathways, KEGG, miRDB, and microT-CDS to identify the significance of hsa-miR-181a-5p and its underlying target. Afterward, the U373 cell line was selected and transfected with… More >

CHAOQUN WANG¹, TING ZHANG², CHAOHE ZHANG^3,*

Oncology Research, Vol.32, No.12, pp. 1867-1879, 2024, DOI:10.32604/or.2024.044547 - 13 November 2024

Abstract Background: Drug resistance is the main factor contributing to cancer recurrence and poor prognosis. Exploration of drug resistance-related mechanisms and effective therapeutic targets are the aim of molecular targeted therapy. In our study, the role of long non-coding RNA (lncRNA) AFAP1-AS1 in gemcitabine resistance and related mechanisms were explored in cervical cancer cells. Methods: Gemcitabine-resistant cervical cancer cell lines HT-3-Gem and SW756-Gem were constructed using the gemcitabine concentration gradient method. The overall survival rates and recurrence-free survival rates were evaluated by Kaplan-Meier analysis. The interaction was verified through a Dual-luciferase reporter gene assay and a… More > Graphic Abstract

KURT SARTORIUS^1,2,3,*, BENN SARTORIUS⁴, CHERIE WINKLER⁵, ANIL CHUTURGOON², ANNA KRAMVIS¹, PING AN⁵, WEIGANG ZHANG⁶, YUNJIE LU^3,6,7,*

BIOCELL, Vol.48, No.11, pp. 1543-1567, 2024, DOI:10.32604/biocell.2024.055505 - 07 November 2024

Abstract Hepatitis B-associated hepatocellular carcinoma (HBV-HCC) remains an intractable high-mortality solid tumor cancer that accounted for 42% of global HCC cases in 2019. Despite some developments in systemic therapy, only a small subset of late-stage HCC patients responds positively to recently developed therapeutic innovations. MicroRNAs (miRNAs) act as an ancillary epigenetic system that can regulate genome expression in all cancer pathways including HCC. The molecular mechanisms of miRNA regulation in cancer pathogenesis offered researchers a new approach that was widely hoped would translate into miRNA-based drugs and diagnostics. Thirty years on, miRNA-based diagnostic and therapeutic agents… More >

Zhenhua Gao¹, Bin Han^1,*, Shengyuan Niu¹, Liying Li¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.3, pp. 1-4, 2024, DOI:10.32604/icces.2024.013339

Abstract With the rapid development of industry and globalization, the demand and strategic importance of oil and natural gas have become increasingly significant, leading to energy extraction in more complex corrosive environments [1, 2]. Bimetallic composite pipes, which offer strength and corrosion resistance, exhibit promising potential. For the welding of bimetallic composite plates, it is optimal to follow the welding sequence of the base layer, transition layer, and inner layer [3, 4]. For the welding of bimetal composite pipes, due to the diameter limit, the inner layer is usually welded first, followed by the transition layer,… More >

Wushuai Liu¹, Wu Xu^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.3, pp. 1-1, 2024, DOI:10.32604/icces.2024.012893

Abstract It is of great significance for improving the in-plane fracture toughness of 3D woven composite (3DWC) to study the failure mechanism of a single edge notch tension (SENT) test. It requires a relatively high computational cost to establish the SENT model based on conformal modeling method. A SENT is established using a proposed ternary model. The matrix cracking, yarn rupture, and debonding at the yarn/matrix interface are involved in the ternary model. Based on the developed SENT model, the progressive damage initiation and evolution of 3DWC SENT are predicted. The load-displacement curves and damage of More >

Junrong Wang^1,2,*, Kuang He¹, Botao Xie³, Chunlei He¹, Wenbin Wu^1,2

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.011711

Abstract Internal solitary waves (ISWs) a serious threat to moored floating structures in deep water, especially in South China Sea. On predicating dynamic response of a moored structure subjected to ISWs, previous researchers directly apply the pre-calculated ISW loading to the structure, which ignores the coupling effects between the structure and the ISW. To address this issue, this paper develops a coupled dynamic analysis model for moored structures, where the determination of ISW loading considers the effects of dynamic responses of floating structures. This model can simulate the action of various loading components on the floating… More >

Fajri Marindra Siregar^1,2, Sofia Mubarika Haryana³, Dyah Wulan Anggrahini⁴, Lucia Kris Dinarti⁴, Anggoro Budi Hartopo^4,*

Congenital Heart Disease, Vol.19, No.4, pp. 375-388, 2024, DOI:10.32604/chd.2024.054742 - 31 October 2024

Abstract A particular type of endogenous noncoding RNAs known as circular RNAs (circRNAs) has now become possible biomarkers for several diseases because of their stability and tissue-specific expression patterns. CircRNAs might play a role in various of biological processes. The identification of particular circRNAs dysregulated in pulmonary arterial hypertension (PAH) raises the possibility of these molecules serving as biomarkers for the disease’s early diagnosis and treatment. This review mainly summarizes the role and potential of circRNA as a future biomarker in PAH related to congenital heart disease. This study presented several potential circRNA targets as diagnostic More > Graphic Abstract