Ling Li, He-Sheng Luo
Oncology Research, Vol.26, No.1, pp. 27-35, 2018, DOI:10.3727/096504017X14900515946914
Abstract Colorectal carcinoma is one of the leading causes of cancer-related deaths and has a high tendency for metastasis, which makes it a priority to find novel methods to diagnose and treat colorectal carcinoma at a very early
stage. We studied the role of the regulator of G-protein signaling (RGS) family of proteins RGS17 in colorectal
carcinoma growth and metastasis. We found that RGS17 was upregulated in both clinical colorectal carcinoma
tissues and cultured colorectal carcinoma cells. Knockdown of RGS17 by specific siRNA decreased the cell
proliferation rate, whereas overexpression of RGS17 with expression plasmid increased More >
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