Liu Feng*†, Wang Wei*, Zhang Heng†, Han Yantao‡, Wang Chunbo‡
Oncology Research, Vol.24, No.5, pp. 315-325, 2016, DOI:10.3727/096504016X14666990347590
Abstract REV7 (also known as MAD2L2) is a multifunctional protein involved in DNA damage tolerance, cell cycle
regulation, gene expression, and carcinogenesis. Although its expression is reportedly associated with poor
prognosis in several kinds of human cancers, the significance of REV7 expression in breast malignancies
is unclear. In this study, REV7 was found to be increased in breast cancer. We found that knockdown of
REV7 inhibited the migration, invasion, and epithelial–mesenchymal transition (EMT) of breast cancer cells.
Meanwhile, overexpression of REV7 promoted the migration, invasion, and EMT of breast cancer cells. As
shown by Western blot, More >
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