Minglei Zhang*, Dapeng Wang†, Tongtong Zhu*, Ruofeng Yin*
Oncology Research, Vol.25, No.1, pp. 83-91, 2017, DOI:10.3727/096504016X14719078133447
Abstract RASSF4, a member of the RASSF family, is broadly expressed in normal tissues but often inactivated in human
cancers. Despite various studies on RASSF4, its role in osteosarcoma remains unclear. Therefore, in this study,
we investigated the effects of RASSF4 expression on osteosarcoma cells and explored the underlying mechanism. The results of our study showed that RASSF4 was lowly expressed in osteosarcoma tissues and cells.
RASSF4 overexpression significantly inhibited proliferation, migration, and invasion as well as the EMT process in osteosarcoma cells. Meanwhile, we found that RASSF4 overexpression markedly decreased the protein
expression of β-catenin, More >
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