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    ARTICLE

    RASAL2 acts as a tumor suppressor in cervical cancer cells

    LI CHEN1,2, FANGFANG LI2, SHOUYAN CAO2, XIA LI2, CHAO ZHOU2, SAI HAN1,*, YOUZHONG ZHANG1,*

    BIOCELL, Vol.47, No.7, pp. 1549-1560, 2023, DOI:10.32604/biocell.2023.027308

    Abstract Background: This study was designed to investigate the roles of RASAL2 in cervical cancer (CC). Methods: Fifty-four CC tissues and 33 adjacent tissues were obtained from CC patients admitted to our hospital between March 2012 and June 2014. Real-time polymerase chain reaction and western blotting were performed to analyze the expression of RASAL2 mRNA and protein in these tissues, CC cell lines, and normal cervical cells. Over-expression and silencing of RASAL2 were induced after transfection, and the migration, invasion, and proliferation of the CC cell lines were examined. Results: RASAL2 mRNA and protein expressions were significantly down-regulated More >

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