Jian Feng^*, Tian Liu, Cailing Du

CMC-Computers, Materials & Continua, Vol.81, No.2, pp. 2895-2909, 2024, DOI:10.32604/cmc.2024.056434 - 18 November 2024

Abstract Unsupervised learning methods such as graph contrastive learning have been used for dynamic graph representation learning to eliminate the dependence of labels. However, existing studies neglect positional information when learning discrete snapshots, resulting in insufficient network topology learning. At the same time, due to the lack of appropriate data augmentation methods, it is difficult to capture the evolving patterns of the network effectively. To address the above problems, a position-aware and subgraph enhanced dynamic graph contrastive learning method is proposed for discrete-time dynamic graphs. Firstly, the global snapshot is built based on the historical snapshots… More >

Mohana Priya Govindarajan^*, Sangeetha Subramaniam Karuppaiya Bharathi

CMC-Computers, Materials & Continua, Vol.81, No.2, pp. 2967-2986, 2024, DOI:10.32604/cmc.2024.055536 - 18 November 2024

Abstract In the present research, we describe a computer-aided detection (CAD) method aimed at automatic fetal head circumference (HC) measurement in 2D ultrasonography pictures during all trimesters of pregnancy. The HC might be utilized toward determining gestational age and tracking fetal development. This automated approach is particularly valuable in low-resource settings where access to trained sonographers is limited. The CAD system is divided into two steps: to begin, Haar-like characteristics were extracted from ultrasound pictures in order to train a classifier using random forests to find the fetal skull. We identified the HC using dynamic programming,… More >

WEITAO ZHENG¹, DONG JIANG², SONGEN CHEN¹, MEILING WU¹, BAOQI YAN², JIAHUI ZHAI², YUNQIANG SHI², BIN XIE¹, XINGWANG XIE², KANGHONG HU^1,*, WENXUE MA^3,*

Oncology Research, Vol.32, No.12, pp. 1837-1850, 2024, DOI:10.32604/or.2024.056565 - 13 November 2024

Abstract Objectives: The Kirsten rat sarcoma virus (KRAS) G12D oncogenic mutation poses a significant challenge in treating solid tumors due to the lack of specific and effective therapeutic interventions. This study aims to explore innovative approaches in T cell receptor (TCR) engineering and characterization to target the KRAS G12D_7-16 mutation, providing potential strategies for overcoming this therapeutic challenge. Methods: In this innovative study, we engineered and characterized two T cell receptors (TCRs), KDA11-01 and KDA11-02 with high affinity for the KRAS G12D_7-16 mutation. These TCRs were isolated from tumor-infiltrating lymphocytes (TILs) derived from tumor tissues of patients More >

CHUAN JIANG^1,2, CHUNLEI LIU^1,3, XI YAO^1,3, JINGYA SU^1,2, WEI LU^1,3, ZHENGBO WEI^3,*, YING XIE^1,2,*

Oncology Research, Vol.32, No.12, pp. 1935-1948, 2024, DOI:10.32604/or.2024.052244 - 13 November 2024

Abstract Background: Head and neck squamous cell carcinoma (HNSCC) is a prevalent form of cancer globally, with chemoresistance posing a major challenge in treatment outcomes. The efficacy of the commonly used chemotherapeutic agent, cisplatin, is diminished in patients with poor prognoses. Methods: Various bioinformatics databases were utilized to examine Carboxylesterase 1 (CES1) gene expression, clinicopathologic features, patient survival analysis, and gene function. An organoid model of HNSCC was established, along with the induction of drug-resistant HNSCC in the organoid model. CES1 expression was assessed using qRT-PCR and Western Blot, and differential markers were identified through transcriptome… More >

HUI ZHOU^#, ZHENGYU YU^#, JING XU, ZHONGWANG WANG, YALI TAO, JINJIN WANG, PEIPEI YANG, JINRONG YANG^*, TING NIU^*

Oncology Research, Vol.32, No.12, pp. 1903-1919, 2024, DOI:10.32604/or.2024.048138 - 13 November 2024

Abstract Background: Dihydrolipoamide S-acetyltransferase (DLAT) is a subunit of the pyruvate dehydrogenase complex (PDC), a rate-limiting enzyme complex, that can participate in either glycolysis or the tricarboxylic acid cycle (TCA). However, the pathogenesis is not fully understood. We aimed to perform a more systematic and comprehensive analysis of DLAT in the occurrence and progression of tumors, and to investigate its function in patients’ prognosis and immunotherapy. Methods: The differential expression, diagnosis, prognosis, genetic and epigenetic alterations, tumor microenvironment, stemness, immune infiltration cells, function enrichment, single-cell analysis, and drug response across cancers were conducted based on multiple computational… More > Graphic Abstract

Jie Wang^1,*, Jingyu Gu¹, Shuai Li¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.012184

Abstract The interaction between the particle and the bubble under the ultrasonic wave excitation plays a pivotal role in various applications such as targeted therapy, ultrasonic cleaning, ultrasonography, and microbubble motors. When the particle is in close proximity or even attached to the bubble, a strong fluid-structure interaction occurs, significantly influencing the particle propulsion. The attachment of the bubble to the particle results in distinct bubble pulsation patterns and particle acceleration mechanisms from the non-contact state. Thus, we propose a fluid-structure interaction model based on the boundary integral method (BIM) to comprehensively consider the distance between More >

Muhammad Imran Ghafoor¹, Awad Bin Naeem^2,*, Biswaranjan Senapati³, Md. Sakiul Islam Sudman⁴, Satyabrata Pradhan⁵, Debabrata Das⁶, Friban Almeida⁶, Hesham A. Sakr⁷

Intelligent Automation & Soft Computing, Vol.39, No.5, pp. 783-803, 2024, DOI:10.32604/iasc.2024.050819 - 31 October 2024

Abstract The confidentiality of pseudonymous authentication and secure data transmission is essential for the protection of information and mitigating risks posed by compromised vehicles. The Internet of Vehicles has meaningful applications, enabling connected and autonomous vehicles to interact with infrastructure, sensors, computing nodes, humans, and fellow vehicles. Vehicular hoc networks play an essential role in enhancing driving efficiency and safety by reducing traffic congestion while adhering to cryptographic security standards. This paper introduces a privacy-preserving Vehicle-to-Infrastructure authentication, utilizing encryption and the Moore curve. The proposed approach enables a vehicle to deduce the planned itinerary of Roadside More >

Xiong Zhang^1,2,*, Jinkang Xiong¹, Xinrong Fu¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.011760

Abstract Thin-walled beams are widely applied as energy-absorbing components in industrial products to meet the requirements of passive safety. Researchers have tried various approaches to improve the energy absorption efficiency of them. Recently, adopting arched beams was proposed by researchers to improve the crashworthiness of beams under transverse loads. Arched beams can switch the transverse forces to axial forces and were reported to show very much better crashworthiness performances than straight beams.
Although adopting arched beams is an effective way to improve the performance of beams under transverse loads, the fabrication of arched beams is more… More >

Milos Dobrojevic^1,4, Luka Jovanovic¹, Lepa Babic³, Miroslav Cajic⁵, Tamara Zivkovic⁶, Miodrag Zivkovic², Suresh Muthusamy⁷, Milos Antonijevic², Nebojsa Bacanin^2,4,8,9,*

CMC-Computers, Materials & Continua, Vol.80, No.3, pp. 4997-5027, 2024, DOI:10.32604/cmc.2024.054459 - 12 September 2024

Abstract Cyberbullying is a form of harassment or bullying that takes place online or through digital devices like smartphones, computers, or tablets. It can occur through various channels, such as social media, text messages, online forums, or gaming platforms. Cyberbullying involves using technology to intentionally harm, harass, or intimidate others and may take different forms, including exclusion, doxing, impersonation, harassment, and cyberstalking. Unfortunately, due to the rapid growth of malicious internet users, this social phenomenon is becoming more frequent, and there is a huge need to address this issue. Therefore, the main goal of the research… More >

Xu Sun, Yinhui Yu^*, Qing Cheng

CMC-Computers, Materials & Continua, Vol.80, No.3, pp. 4149-4171, 2024, DOI:10.32604/cmc.2024.052725 - 12 September 2024

Abstract Object detection in unmanned aerial vehicle (UAV) aerial images has become increasingly important in military and civil applications. General object detection models are not robust enough against interclass similarity and intraclass variability of small objects, and UAV-specific nuisances such as uncontrolled weather conditions. Unlike previous approaches focusing on high-level semantic information, we report the importance of underlying features to improve detection accuracy and robustness from the information-theoretic perspective. Specifically, we propose a robust and discriminative feature learning approach through mutual information maximization (RD-MIM), which can be integrated into numerous object detection methods for aerial images.… More >