SHUOCHEN PANG1, TAO JIA1,*, ZIFENG YANG2,*
BIOCELL, Vol.48, No.12, pp. 1721-1734, 2024, DOI:10.32604/biocell.2024.055753
- 30 December 2024
Abstract The Receptor for Advanced Glycation End Products (RAGE) is a multiligand receptor of the immunoglobulin superfamily, notably highly expressed in the lungs. Its interaction with a variety of ligands, including advanced glycation end products (AGEs), S100 proteins, and high mobility group box 1 (HMGB1), activates multiple signaling pathways that are pivotal in the pathogenesis of numerous pulmonary diseases and comorbidities. However, comprehensive reviews on the role of ligands-RAGE signaling in specific lung diseases are rare. This review aims to elucidate the mechanisms by which RAGE-mediated signaling pathways either provide protective or pathogenic effects in pulmonary More >
Login
Register
