MINGHAO LI1, YOULI QIU2, WENHUI ZHANG1, RUIHAO SUN1, MEIJIN DU1, LUZE YANG3, YU LI1,*
BIOCELL, Vol.44, No.2, pp. 247-255, 2020, DOI:10.32604/biocell.2020.08835
- 27 May 2020
Abstract While phthalate acid esters (PAEs) cannot fluoresce alone, they can be detected by fluorescence spectroscopy
after chelation with bovine serum albumin (BSA). In this study, the types of amino acid residues at the active site of PAEs
chelated with BSA were determined using molecular docking technology. A modification scheme of BSA with higher
detection sensitivity fluorescence spectroscopy for PAEs was proposed based on the docking results and constructed
for a novel BSA structure with a higher detection sensitivity of fluorescence spectroscopy using a homologous
modeling method. Density functional theory (DFT) was employed to explore the… More >
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