Fang Wang, Zhihong Wang, Xiaoli Gu, Jinquan Cui
Oncology Research, Vol.25, No.1, pp. 107-114, 2017, DOI:10.3727/096504016X14732772150145
Abstract Ovarian cancer remains as one of the most threatening malignancies for females in the world. This study investigated the pivotal role of miR-940 in the progression of ovarian cancer and to reveal the possible molecular
mechanism of its action. Ovarian cancer OVCAR3 cells were transfected with the miR-940 vector, miR-940
inhibitor, and/or small interfering RNA (siRNA) targeting PKC-d (si-PKC-δ), respectively. After transfection,
cell viability and cell apoptosis were analyzed, as well as cell proliferation and apoptosis-related protein expression. Compared to the control, miR-940 upregulation suppressed cell viability but induced cell apoptosis. miR-
940 upregulation increased… More >
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