He-Peng Cheng1, Qian Liu1, Yang Li, Xiao-Dong Li, Chao-Yang Zhu
Oncology Research, Vol.25, No.4, pp. 587-593, 2017, DOI:10.3727/096504016X14761811155298
Abstract Protein disulfide isomerases A6 (PDIA6) belongs to the PDI family. Recently, PDIA6 was found to have a close
association with various cancers. However, there has been little investigation into the biological functions of
PDIA6 in bladder cancer (BC). In this study, we explored the expression pattern and functional significance
of PDIA6 in BC. We found that PDIA6 was overexpressed in BC tissues and cell lines. The in vitro study
showed that PDIA6 downregulation significantly inhibited BC proliferation and invasion. In addition, the
in vivo experiment demonstrated that PDIA6 downregulation decreased the volume, weight, and metastasis More >
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