Yanhuan Lin^1,#, Hua Du^2,#, Zhitao Ye², Shuqi Wang², Zhen Wang², Xiaojuan Liu^2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.1, pp. 137-150, 2024, DOI:10.32604/phyton.2023.044996 - 26 January 2024

Abstract PDI is a molecular chaperone and plays an important role in Endoplasmic Reticulum quality control (ERQC). PDI participates in the refolding of the misfolded/unfolded proteins to maintain cellular homeostasis under different stresses. However, bioinformatic characteristics and potential functions of PDIs in diatom Phaeodactylum tricornutum (Pt) are still unknown so far. Hence, the genome-wide characteristics of PtPDI proteins in P. tricornutum were first studied via bioinformatic and transcriptomic methods. 42 PtPDI genes were identified from the genome of P. tricornutum. The motif, protein structure, classification, number of introns, phylogenetic relationship, and the expression level of 42 PtPDI genes under… More >

He-Peng Cheng¹, Qian Liu¹, Yang Li, Xiao-Dong Li, Chao-Yang Zhu

Oncology Research, Vol.25, No.4, pp. 587-593, 2017, DOI:10.3727/096504016X14761811155298

Abstract Protein disulfide isomerases A6 (PDIA6) belongs to the PDI family. Recently, PDIA6 was found to have a close association with various cancers. However, there has been little investigation into the biological functions of PDIA6 in bladder cancer (BC). In this study, we explored the expression pattern and functional significance of PDIA6 in BC. We found that PDIA6 was overexpressed in BC tissues and cell lines. The in vitro study showed that PDIA6 downregulation significantly inhibited BC proliferation and invasion. In addition, the in vivo experiment demonstrated that PDIA6 downregulation decreased the volume, weight, and metastasis More >