Chaonan Ma*1, Wei Ma*1, Nannan Zhou*, Na Chen*, Li An†, Yijie Zhang*
Oncology Research, Vol.25, No.5, pp. 781-787, 2017, DOI:10.3727/096504016X14772417575982
Abstract Protease serine S1 family member 8 (PRSS8), a membrane-anchored serine protease, has been reported to be
involved in the development of several human cancers. However, the role of PRSS8 in non-small cell lung
cancer (NSCLC) pathogenesis remains unclear. The objective of this study was to investigate PRSS8 expression, biological function, and its related molecular mechanism in NSCLC. Our results showed that PRSS8 was
expressed in a low amount in NSCLC cell lines. Ectopic expression of PRSS8 inhibited tumor growth in vitro
and in vivo. Furthermore, ectopic expression of PRSS8 inhibited the migration and invasion of More >
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