Hu-yin Yang, Da-zhao Fang, Lian-shu Ding, Xiao-bo Hui, Dai Liu
Oncology Research, Vol.25, No.6, pp. 923-930, 2017, DOI:10.3727/096504016X14798241682647
Abstract Protease serine 8 (PRSS8), a serine peptidase, has a widespread expression in normal epidermal cells. Recently,
many researchers demonstrated downregulation of PRSS8 in cancer tissues as well as its tumor suppressor role
in cancer development. However, the biological functions of PRSS8 in glioma remain unclear. In the current
study, we demonstrated a decreased expression of PRSS8 in glioma tissues and cell lines. PRSS8 upregulation
inhibited glioma cell proliferation, migration, and invasion. In addition, xenograft experiments showed that
PRSS8 overexpression suppressed glioma cell growth in vivo. We also found that upregulated PRSS8 reduced
the protein expression More >
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