Zhongjun Li*, Junxiu Guo*, Yujie Ma†, Longbo Zhang†, Zhixiong Lin*
Oncology Research, Vol.26, No.2, pp. 219-230, 2018, DOI:10.3727/096504017X14944585873659
Abstract MicroRNAs (miRs) have been found to play promoting or suppressive roles in different human cancers.
However, the exact regulatory mechanism of miR-30b in glioblastoma remains unknown. Here we have shown
that the expression of miR-30b is significantly increased in glioblastoma tissues and cell lines. Moreover, a
high expression of miR-30b is significantly associated with a shorter survival time for glioblastoma patients.
Knockdown of miR-30b caused a significant reduction in the proliferation, migration, and invasion of U87
and A172 cells. Proline-rich transmembrane protein 2 (PRRT2) was further identified as a novel target gene of
miR-30b, and More >
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