Alaa Amash1,2, Adi Y. Weintraub3, Eyal Sheiner2,3, Atef Zeadna3, Mahmoud Huleihel1,2,*, Gershon Holcberg2,3,*
European Cytokine Network, Vol.21, No.1, pp. 58-64, 2010, DOI:10.1684/ecn.2009.0178
Abstract Objective. To examine the effect of magnesium sulfate (MgSO4) on tumor necrosis factor-alpha (TNF-α)
secretion by preeclamptic placentas. Study design. Cotyledons of six, term, normotensive and ten, pre-eclamptic pla-centas
were dually perfused for six hours (6h), with MgSO4 (6-7 mg %) in the maternal reservoir [normotensive
(n = 3); pre-eclamptic (n = 5)], and with control medium (without MgSO4) [normotensive (n = 3); pre-eclamptic
(n = 5)]. Perfusate samples from the maternal and the fetal circulations were collected every 30 min throughout the 6h
of perfusion, and examined for TNF- α levels using ELISA. Statistical significance was… More >
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