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    ARTICLE

    Inhibitory Effect of Ponkan (Citrus reticulata ‘Ponkan’) Flavonoids on Oral Ulcers through Jak2-Stat3 Signaling Pathway

    Lili Liu1, Can Hu4, Huilin Cheng1, Chuangju Ma1, Jiancheng Sun1, Yunyi Chen2, Manxi Wu2, Han Yang2, Cui Sun2,3, Jinping Cao2,3, Dengliang Wang1,*, Yue Wang2,*, Chongde Sun2,3

    Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2499-2518, 2024, DOI:10.32604/phyton.2024.054449 - 30 September 2024

    Abstract Oral ulcers, a common mucosal affliction, severely diminish patients’ quality of life due to pain and discomfort. Despite existing treatments, the frequent recurrence of oral ulcers underscores the need for more effective therapeutic options. This study aimed to investigate the inhibitory effects of Ponkan (Citrus reticulata ‘Ponkan’) extracts and their flavonoid components on oral ulcers, exploring their potential as a natural therapy. Twenty different Ponkan cultivars were selected for flavonoid extraction and analysis. Ultra-performance liquid chromatography (UPLC) and high-resolution mass spectrometry (HRMS) were utilized for substance identification, leading to the discovery of 16 flavonoid compounds. Using… More > Graphic Abstract

    Inhibitory Effect of Ponkan (<i>Citrus reticulata</i> ‘Ponkan’) Flavonoids on Oral Ulcers through Jak2-Stat3 Signaling Pathway

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