Ming Zhang*, Change Gao†, Yi Yang*, Gaofeng Li‡, Jian Dong§, Yiqin Ai*, Nan Chen‡, Wenhui Li*
Oncology Research, Vol.26, No.8, pp. 1245-1255, 2018, DOI:10.3727/096504017X14944585873668
Abstract Long noncoding RNAs (lncRNAs), a new class of functional regulators involved in human tumorigenesis,
have been attracting the increasing attention of researchers. The lncRNA colorectal neoplasia differentially
expressed (CRNDE) gene, transcribed from chromosome 16 on the strand opposite the adjacent IRX5 gene,
was originally found to be increased in CRC and was reported to be abnormally expressed in many cancers.
However, its potential role and the molecular mechanism underlying the radioresistant phenotype formation of
lung adenocarcinoma (LAD) remain unclear. In our present study, we identified that CRNDE was significantly
upregulated in LAD tissue and radioresistant… More >
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